Distribution and Excretion of Radioactivity after Administration of Morphine-N-methyl C14 to Rats.

March, Cyril; Elliott, Henry W.

doi:10.3181/00379727-86-21145

“…6) and peristalsis was, as judged by the accumulation of foul smelling contents in the small intestine, impeded, but it could have been, for instance, a direct effect of morphine on the tapeworm. [A large proportion of morphine injected parietally is eliminated via the faeces in a rat (March & Elliott, 1954). ]…”

Section: (B) Migration Of Surgically Transplanted Wormsmentioning

confidence: 99%

The migration of Hymenolepis diminuta in the rat's intestine during normal development and following surgical transplantation

Bråten

¹

,

Hopkins

²

1969

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…The other possible reason for the simple first order kinetics might be that the liver acts as a sink for a significant time i. e. a high partition coefficient of the drug between the eliminating organ and the emergent blood (ROWLAND et al 1973). However, this is probably not the case since distribution studies have shown that the liver does not accumulate morphine to any appreciable amount (MARCH & ELLIOTT 1954;MILLER & ELLIOTT 1955).…”

Section: Discussionmentioning

confidence: 99%

Metabolism of Morphine in the Perfused Rat Liver

Dahlström

¹

,

Jonsson

²

,

Paalzow

³

1976

Acta Pharmacologica et Toxicologica

9

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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“…It has been shown that the liver rapidly destroys analgesic drugs (Sung & Way, 1950;Bonnycastle & Delia, 1950). It has been suggested that morphine may be partly N-demethylated to normorphine in liver and brain of several species (March & Elliot, 1954;Axelrod, 1956;Mellet & Woods, 1961;Misra, Mule & Woods, 1961;Milthers, 1962a, b). Glucuronide formation in the liver is, however, probably the most significant factor in the termination of the actions of morphine (Way & Adler, 1961).…”

Section: Discussionmentioning

confidence: 99%

The analgesic action of morphine‐N‐oxide

Fennessy

¹

1968

British J Pharmacology

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

show abstract

Distribution and Excretion of Radioactivity after Administration of Morphine-N-methyl C14 to Rats.

Cited by 31 publications

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The migration of Hymenolepis diminuta in the rat's intestine during normal development and following surgical transplantation

The migration of Hymenolepis diminuta in the rat's intestine during normal development and following surgical transplantation

Metabolism of Morphine in the Perfused Rat Liver

The analgesic action of morphine‐N‐oxide

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