Distribution and diversity of Candida tropicalis strains in different marine environments

Yan, Kuiran; Zhang, Ying; Chi, Zhen‐Ming

doi:10.1007/s11802-010-0139-0

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Similarly, Papadakis et al (1997) reported C. albicans, C. tropicalis and Trichosporon spp at bathing beaches in Greece. In a study along the coast of China, Yan et al (2010), indicated that C. tropicalis has a wide distribution in marine environments, where the species may play an important role. In addition, we isolated C. tropicalis in the vicinity of human inhabitations from waters of the reef off Rendezvous Cay, Belize and from mangrove habitats of the Monkey River and Middle Long Cay, Belize (Fell and Statzell-Tallman, unpublished data).…”

Section: Resultsmentioning

confidence: 99%

Five new species of yeasts from fresh water and marine habitats in the Florida Everglades

Fell

Statzell-Tallman

Scorzetti

et al. 2010

Antonie van Leeuwenhoek

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Yeast populations in the Shark River Slough of the Florida Everglades, USA, were examined during a 3-year period (2002-2005) at six locations ranging from fresh water marshes to marine mangroves. Seventy-four described species (33 ascomycetes and 41 basidiomycetes) and an approximately equal number of undescribed species were isolated during the course of the investigation. Serious human pathogens, such as Candida tropicalis, were not observed, which indicates that their presence in coastal waters is due to sources of pollution. Some of the observed species were widespread throughout the fresh water and marine habitats, whereas others appeared to be habitat restricted. Species occurrence ranged from prevalent to rare. Five representative unknown species were selected for formal description. The five species comprise two ascomycetes: Candida sharkiensis sp. nov. (CBS 11368(T)) and Candida rhizophoriensis sp. nov. (CBS 11402(T)) (Saccharomycetales, Metschnikowiaceae), and three basidiomycetes: Rhodotorula cladiensis sp. nov. (CBS 10878(T)) in the Sakaguchia clade (Cystobasidiomycetes), Rhodotorula evergladiensis sp. nov. (CBS 10880(T)) in the Rhodosporidium toruloides clade (Microbotryomycetes, Sporidiobolales) and Cryptococcus mangaliensis sp. nov. (CBS 10870(T)) in the Bulleromyces clade (Agaricomycotina, Tremellales).

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Section: Resultsmentioning

confidence: 99%

Five new species of yeasts from fresh water and marine habitats in the Florida Everglades

Fell

Statzell-Tallman

Scorzetti

et al. 2010

Antonie van Leeuwenhoek

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Section: Candida Auris Persistence and Cycling In The Enviro...mentioning

confidence: 99%

“…A major determinant of the ability of microbial species to persist in marine environments is the ability to withstand cationic stress due to high salt concentration, and several species of Candida species are frequently found in marine environments [37,41,44,45,100,101]. The halotolerance of C. auris (and its hypothesised emergence from the marine environment) could facilitate the survival of C. auris and its subsequent dissemination over large distances [77,80,99].…”

Section: Candida Auris Persistence and Cycling In The Environmentmentioning

confidence: 99%

Environmental reservoirs of the drug-resistant pathogenic yeast Candida auris

2023

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Candia auris is an emerging human pathogenic yeast; yet, despite phenotypic attributes and genomic evidence suggesting that it probably emerged from a natural reservoir, we know nothing about the environmental phase of its life cycle and the transmission pathways associated with it. The thermotolerant characteristics of C. auris have been hypothesised to be an environmental adaptation to increasing temperatures due to global warming (which may have facilitated its ability to tolerate the mammalian thermal barrier that is considered a protective strategy for humans against colonisation by environmental fungi with pathogenic potential). Thus, C. auris may be the first human pathogenic fungus to have emerged as a result of climate change. In addition, the release of antifungal chemicals, such as azoles, into the environment (from both pharmaceutical and agricultural sources) is likely to be responsible for the environmental enrichment of resistant strains of C. auris; however, the survival and dissemination of C. auris in the natural environment is poorly understood. In this paper, we critically review the possible pathways through which C. auris can be introduced into the environment and evaluate the environmental characteristics that can influence its persistence and transmission in natural environments. Identifying potential environmental niches and reservoirs of C. auris and understanding its emergence against a backdrop of climate change and environmental pollution will be crucial for the development of effective epidemiological and environmental management responses.

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“…In most mammals, C. albicans is present as a commensal microbe [28,29], whereas C. tropicalis is found in certain mammals and in mangrove sediments, seawater, beaches, sea sediments, and soils in tropical and subtropical regions [30,31]. As a key component of chitin and of the extracellular matrix of animals, GlcNAc is widely present in the environment and in the mammalian hosts, including in the gastrointestinal tract and in the extracellular matrix environment, where it is present within glycosaminoglycans [32,33].…”

Section: Introductionmentioning

confidence: 99%

NGT1 Is Essential for N-Acetylglucosamine-Mediated Filamentous Growth Inhibition and HXK1 Functions as a Positive Regulator of Filamentous Growth in Candida tropicalis

Zhang

Yuan

et al. 2020

IJMS

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Candida tropicalis is a pathogenic fungus that can cause opportunistic infections in humans. The ability of Candida species to transition between yeast and filamentous growth forms is essential to their ability to undergo environmental adaptation and to maintain virulence. In other fungal species, such as Candida albicans, N-acetylglucosamine (GlcNAc) can induce filamentous growth, whereas it suppresses such growth in C. tropicalis. In the present study, we found that knocking out the GlcNA-specific transporter gene NGT1 was sufficient to enhance C. tropicalis filamentous growth on Lee’s plus GlcNAc medium. This suggests that GlcNAc uptake into C. tropicalis cells is essential to the disruption of mycelial growth. As such, we further studied how GlcNAc catabolism-related genes were able to influence C. tropicalis filamentation. We found that HXK1 overexpression drove filamentous growth on Lee’s media containing glucose and GlcNAc, whereas the deletion of the same gene disrupted this filamentous growth. Interestingly, the deletion of the DAC1 or NAG1 genes impaired C. tropicalis growth on Lee’s plus GlcNAc plates. Overall, these results indicate that HXK1 can serve as a positive regulator of filamentous growth, with excess GlcNAc-6-PO4 accumulation being toxic to C. tropicalis. These findings may highlight novel therapeutic targets worthy of future investigation.

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Distribution and diversity of Candida tropicalis strains in different marine environments

Cited by 6 publications

References 19 publications

Five new species of yeasts from fresh water and marine habitats in the Florida Everglades

Five new species of yeasts from fresh water and marine habitats in the Florida Everglades

Environmental reservoirs of the drug-resistant pathogenic yeast Candida auris

NGT1 Is Essential for N-Acetylglucosamine-Mediated Filamentous Growth Inhibition and HXK1 Functions as a Positive Regulator of Filamentous Growth in Candida tropicalis

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