Distribution and determinants of serum high-sensitivity C-reactive protein in Ethiopian population

Challa, Feyissa; Gelibo, Terefe; Getahun, Tigist; Sileshi, Meron; Geto, Zeleke; Bekele, Abebe; Getachew, Theodros; Defar, Atkure; Teklie, Habtamu; Nagasa, Bikila; Girma, Fisume; Seifu, Daniel; Tebeje, Solomon; Teferra, Solomon; Wolde, Mistire; Carobene, Anna; Abate, Ebba

doi:10.1016/j.cca.2021.02.013

Cited by 7 publications

(9 citation statements)

References 31 publications

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“…1 ). A cross-sectional community-based study in nine Ethiopian regions, including more than 5.000 recruited participants, reported a percentage of obesity among the population of 2.2% (BMI > 30) [ 41 ] while in US the obesity is a common disease regarding more than 40% of the population [ 42 ]. Africa which have great cultural, linguistic, and historic diversity the cut-off point of waist circumferences depends on western population which might not to be appropriate for Africa population, at least for Ethiopia.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic syndrome among patients with schizophrenia in Ethiopia

et al. 2021

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Background Globally, the prevalence of metabolic syndrome (MetS) is higher among patients with schizophrenia than the general population, and this leads to higher morbidity and mortality in this population. The aim of this study was to investigate the MetS prevalence among patients with schizophrenia in Ethiopia. Methods We conducted a cross-sectional analysis of baseline data of 200 patients with schizophrenia recruited from Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia. Lipid profile and blood glucose levels were measured using Roche Cobas 6000 clinical chemistry analyzer. The prevalence of MetS was assessed based on National Cholesterol Education Program Adult Treatment Panel III criteria. Patients’ demographic information, clinical and laboratory data, lifestyle habits, particularly smoking and Khat chewing, were evaluated vis-à-vis MetS. Results The overall prevalence of MetS in patients with schizophrenia was 21.5% (17.1% male, 29.6% female) where Low HDL-cholesterol value was the most common metabolic disorders components in both males and females subgroups. In the multivariate analysis, the positive and negative symptoms score (PANSS, AOR = 1.03, 95% CI 1.001–1.054) was associated factors with MetS. Conclusion In Ethiopia, patients with schizophrenia were found to have higher prevalence of MetS than the general population. Physicians/health care providers should routinely screen patients with schizophrenia for MetS and initiate timely management of those who develop the syndrome to reduce the health cost from caring for NCDs, improve the patients’ quality of life, and prevent premature mortality.

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Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic syndrome among patients with schizophrenia in Ethiopia

et al. 2021

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“…Fruits and vegetables' antioxidant effects may be mediated by changes in fat mass and decreased adipocyte IL-6 production. 58,59 Previous studies 25,35 discovered a direct link between hsCRP and physical activity. In contrast, no association was found between hsCRP and physical activity, fasting behaviors, meat and/or animal product consumption, or coffee and/or tea consumption in this study.…”

Section: Discussionmentioning

confidence: 99%

“…This finding contradicted the prior two studies done by Tang YB et al 34 and Raitakari M et al 45 Thirty-six (7.32%) of the total study participants had a serum hsCRP of >3 mg/L, which was lower than the earlier Ethiopian study by Feyissa et al, which found 18%. 25 Because the prior study included adult participants who were at high risk for numerous factors that could cause blood hsCRP elevation, the discrepancy was expected. Male children had a median hsCRP value of 0.54 mg/L, while female children had a median hsCRP value of 0.57 mg/L.…”

Section: Discussionmentioning

confidence: 99%

“…However, children under the age of 15 were not included in the previous study, and participants were not tested for non-infectious or infectious disorders such as the human immunodeficiency virus, hepatitis B, hepatitis C, syphilis, or malaria. 25 In cardiovascular illnesses and diabetes, hsCRP has recently been identified as a sensitive marker of low-grade inflammation. 7,27,28 Based on a large data set, the US CDC and the American Heart Association concluded that hsCRP is a useful marker for predicting the risk of future cardiovascular disease and diagnosing and treating patients with acute coronary syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, there are no published hsCRP reference intervals for children in Ethiopia. 25 Therefore, the purpose of this study was to identify the reference intervals (2.5th and 97.5th percentiles) of serum hsCRP in children who appeared to be healthy. The reference intervals supplied could open the path for hsCRP to be used as a marker for early identification of any inflammatory condition in Ethiopia.…”

Section: Introductionmentioning

confidence: 99%

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Determination of high-sensitivity C-reactive protein reference intervals for apparently healthy children in Addis Ababa, Ethiopia

Mohammed,

Kassaw,

Befekadu

et al. 2023

Eur J Inflamm

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Objective: Since then, the reference intervals of serum hsCRP in apparently healthy Ethiopian children are unknown. Therefore, this study aimed to determine the reference intervals of serum hsCRP for apparently healthy children. Methods: In this cross-sectional study, a total of 492 apparently healthy children aged 5–17 years were recruited from residents of Addis Ababa. Well-trained professionals took anthropometric measurements. The biochemical analysis was performed with the automatic biochemical analyzer Cobas Integra 400 Plus from Roche. The 2.5th and 97.5th percentile limits were calculated using a non-parametric method as per the Clinical Laboratory Standard Institute (CLSI) guide. A box plot was used to show the distribution of hsCRP by age and gender. Furthermore, bivariate and multivariable logistic regression analyses were carried out to evaluate factors associated with elevated hsCRP levels. Percentiles were displayed by age subgroup and sex. p-values <0.05 were considered statistically significant. Results: The study included 245 boys and 247 girls. For the age group of 5–11 years, the combined 2.5th and 97.5th percentiles, which can be used as a reference interval for children in Addis Ababa, were 0.15–6.78 mg/L, while for the older age group (12–17 years), the determined percentile was 0.14–4.40 mg/L. Likewise, the current study shows that never or occasionally eating vegetables and/or fruits (AOR = 2.28, 95% CI, 0.84–4.97), and being obese (AOR = 3.63, 95% CI, 1.14–11.53) were independent risk factors for elevated serum hsCRP concentrations. Conclusion: This study is the first to determine the reference intervals of hsCRP concentrations among apparently healthy Ethiopian children. Notable differences were observed in the established percentiles of hsCRP in comparison with published literature.

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