Distribution and Chemical Speciation of Exogenous Micro- and Nanoparticles in Inflamed Soft Tissue Adjacent to Titanium and Ceramic Dental Implants

Nelson, Katja; Hesse, Bernhard; Addison, Owen; Morrell, Alexander P.; Groß, Christian; Lagrange, Adrien; Suarez, Vanessa Isabel Tardillo; Kohal, Ralf; Fretwurst, Tobias

doi:10.1021/acs.analchem.0c02416

Cited by 33 publications

(38 citation statements)

References 63 publications

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“…They also tried to explain the mechanism behind particle release from ceramic implants as a consequence of stress that induces the local transformation of zirconia from a tetragonal to a monoclinic crystalline phase, susceptible to microlesions. The study concluded by reporting on the presence of Ti particles, with variable speciation, in all tissue sections implanted with Ti devices, as well as ceramic products were identified in five out of eight tissue samples around ceramic implants [267].…”

Section: Analytical Methods For the Characterization Of Micro-and Nan...mentioning

confidence: 89%

“…An emerging concept about etiopathogenesis of peri-implantitis has explored the degradation of the implant surface with the consequent particle release as an inflammation catalyst mechanism [267]. This phenomenon has been deeply studied for orthopedic implants, whereby the deterioration of metal biomaterials was demonstrated to accumulate exogenous particles in the peri-implant milieu [268].…”

Section: Analytical Methods For the Characterization Of Micro-and Nan...mentioning

confidence: 99%

“…This phenomenon has been deeply studied for orthopedic implants, whereby the deterioration of metal biomaterials was demonstrated to accumulate exogenous particles in the peri-implant milieu [268]. Likewise, some authors reported that in dental devices, damage to the surface can be caused by both surface instrumentation and dynamic interactions in the implant-abutment interface; however, for titanium devices this can happen, independently from wear corrosion, following a no pre-clinical studied pathway [267,269]. In addition, differences among cell compositions were noticed in case of inflammation in peri-implantitis and periodontitis, with higher macrophage polarization in the first case [270,271].…”

Section: Analytical Methods For the Characterization Of Micro-and Nan...mentioning

confidence: 99%

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Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

et al. 2022

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An increase in the world population and its life expectancy, as well as the ongoing concern about our physical appearance, have elevated the relevance of dental implantology in recent decades. Engineering strategies to improve the survival rate of dental implants have been widely investigated, focusing on implant material composition, geometry (usually guided to reduce stiffness), and interface surrounding tissues. Although efforts to develop different implant surface modifications are being applied in commercial dental prostheses today, the inclusion of surface coatings has gained special interest, as they can be tailored to efficiently enhance osseointegration, as well as to reduce bacterial-related infection, minimizing peri-implantitis appearance and its associated risks. The use of biomaterials to replace teeth has highlighted the need for the development of reliable analytical methods to assess the therapeutic benefits of implants. This literature review considers the state-of-the-art strategies for surface modification or coating and analytical methodologies for increasing the survival rate for teeth restoration.

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Section: Analytical Methods For the Characterization Of Micro-and Nan...mentioning

confidence: 89%

Section: Analytical Methods For the Characterization Of Micro-and Nan...mentioning

confidence: 99%

Section: Analytical Methods For the Characterization Of Micro-and Nan...mentioning

confidence: 99%

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Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

et al. 2022

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“…Nonresorbable fixation systems made of titanium (Ti) are the most widely used applications for this purpose, due to their good mechanical properties and biocompatibility, but are also associated with typical disadvantages, similar to delayed osteointegration and microbial colonization [56,57]. An additional concern is the reported accumulation of material particles around Ti and ceramic implants [58,59] However, the main disadvantage for nonresorbable fixation screws is the requirement for their subsequent surgical removal and the resulting risks for the patient [9,49,56,57,60]. Bioresorbable screws, made from polymers such as polylactide and polyglycolide and their copolymers are also available [22,23,61,62].…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)

Jung

Hesse²,

Stojanović

et al. 2021

IJMS

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Background: Magnesium (Mg) is one of the most promising materials for human use in surgery due to material characteristics such as its elastic modulus as well as its resorbable and regenerative properties. In this study, HF-coated and uncoated novel bioresorbable magnesium fixation screws for maxillofacial and dental surgical applications were investigated in vitro and in vivo to evaluate the biocompatibility of the HF coating. Methods: Mg alloy screws that had either undergone a surface treatment with hydrofluoric-acid (HF) or left untreated were investigated. In vitro investigation included XTT, BrdU and LDH in accordance with the DIN ISO 10993-5/-12. In vivo, the screws were implanted into the tibia of rabbits. After 3 and 6 weeks, degradation, local tissue reactions and bony integration were analyzed histopathologically and histomorphometrically. Additionally, SEM/EDX analysis and synchrotron phase-contrast microtomography (µCT) measurements were conducted. The in vitro analyses revealed that the Mg screws are cytocompatible, with improved results when the surface had been passivated with HF. In vivo, the HF-treated Mg screws implanted showed a reduction in gas formation, slower biodegradation and a better bony integration in comparison to the untreated Mg screws. Histopathologically, the HF-passivated screws induced a layer of macrophages as part of its biodegradation process, whereas the untreated screws caused a slight fibrous tissue reaction. SEM/EDX analysis showed that both screws formed a similar layer of calcium phosphates on their surfaces and were surrounded by bone. Furthermore, the µCT revealed the presence of a metallic core of the screws, a faster absorbing corrosion front and a slow absorbing region of corroded magnesium. Conclusions: Overall, the HF-passivated Mg fixation screws showed significantly better biocompatibility in vitro and in vivo compared to the untreated screws.

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“… 1 More than 12 million dental implants are needed annually worldwide as part of routine oral rehabilitation. 25 …”

Section: Introductionmentioning

confidence: 99%

Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel

et al. 2022

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The limitations to assess dental enamel remineralization have been overcome by a methodology resulting from the appropriate combination of synchrotron radiation-based techniques on both, infrared microspectroscopy and micro X-ray diffraction, with the help of specific data mining. Since amelogenin plays a key role in modulating the mineralization of tooth enamel, we propose a controlled ion release for fluorapatite structural ions (Ca 2+ , PO 4 3– , and F – , also including Zn 2+ ) by using weak acid and weak base ion-exchange resins in the presence of amelogenin to remineralize the surface of etched teeth. This combination provides the necessary ions for enamel remineralization and a guide for crystal growth due to the protein. Remineralized tooth samples were analyzed by applying the indicated methodology. The synchrotron data were treated using principal component analysis and multivariate curve resolution to analyze the mineral layer formed in the presence and absence of amelogenin. The remineralizing treatment created a fluorapatite layer free of carbonate impurities and with a similar orientation to that of the natural enamel thanks to amelogenin contribution.

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Distribution and Chemical Speciation of Exogenous Micro- and Nanoparticles in Inflamed Soft Tissue Adjacent to Titanium and Ceramic Dental Implants

Cited by 33 publications

References 63 publications

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)

Combination of Two Synchrotron Radiation-Based Techniques and Chemometrics to Study an Enhanced Natural Remineralization of Enamel

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