Distribution and characterization of vanilloid receptors in the rat stomach

Nozawa, Yoshihisa; Nishihara, Katsushi; Yamamoto, Akira; Nakano, Masaya; Ajioka, Hirohusa; Matsuura, Naosuke

doi:10.1016/s0304-3940(01)02021-3

Cited by 61 publications

(42 citation statements)

References 16 publications

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“…This receptor is a transient receptor potential-type protein (Caterina and Julius 2001), and mice genetically devoid of it do not show inflammation-mediated hyperalgesia (Caterina and Julius 2001). The VR1 receptor is sensitive to polymodal stimuli (mechanical, thermal, and chemical), which can cause tissue damage, and has been found in unmyelinated type C and thinly myelinated A␦ neurons of the spinal cord, in the lung, bladder, gastrointestinal tract (Nozawa et al 2001), and oral cavity (Caterina and Julius 2001). VR1-positive neurons of the oral cavity of rat are located around taste buds, specifically in the subepithelial lamina propria in fungiform, circumvallate, and foliate taste papillae (Ishida et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Representations of the Texture of Food in the Primate Orbitofrontal Cortex: Neurons Responding to Viscosity, Grittiness, and Capsaicin

Rolls

Verhagen

Kadohisa

2003

Journal of Neurophysiology

140

129

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Rolls, Edmund T., Justus V. Verhagen, and Mikiko Kadohisa. Representations of the texture of food in the primate orbitofrontal cortex: neurons responding to viscosity, grittiness, and capsaicin. J Neurophysiol 90: 3711-3724, 2003. First published August 13, 2003 10.1152/jn.00515.2003. The primate orbitofrontal cortex (OFC) is a site of convergence from taste, olfactory, and somatosensory cortical areas. We describe a population of single neurons in the macaque OFC that responds to the texture of food in the mouth. Use of oral viscosity stimuli consisting of carboxymethylcellulose (CMC) in the range 1-10,000 centipoise showed that the responses of one subset of these neurons were related to stimulus viscosity. Some of the neurons had increasing responses to increasing viscosity, some had decreasing responses, and some neurons were tuned to a range of viscosities. These neurons are a different population to oral fat-sensitive neurons, in that their responses to fats (e.g., safflower oil), to silicone oil [(Si(CH 3 ) 2 O) n ], and to mineral oil (hydrocarbon) depended on the viscosity of these oils. Thus there is a dissociation between texture channels used to sense viscosity and fat. Some of these viscositysensitive single neurons were unimodal (somatosensory; 25%) and some received convergent taste inputs (75%). A second subpopulation of neurons responded to gritty texture (produced by microspheres suspended in CMC). A third subpopulation of neurons responded to capsaicin. These results provide evidence about the information channels used to represent the texture and flavor of food in a part of the brain important in appetitive responses to food and are relevant to understanding the physiological and pathophysiological processes related to food intake, food selection, and the effects of variety of food texture in combination with taste and other inputs that affect food intake.

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Section: Discussionmentioning

confidence: 99%

Representations of the Texture of Food in the Primate Orbitofrontal Cortex: Neurons Responding to Viscosity, Grittiness, and Capsaicin

Rolls

Verhagen

Kadohisa

2003

Journal of Neurophysiology

140

129

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“…Apart from its presence on esophageal epithelial cells, TRPV1 was also found to be expressed in human gastric oxyntic cells and mucous secreting epithelial cells in the rat stomach (Nozawa et al, 2001;Kato et al, 2003;Faussone-Pellegrini et al, 2005). Together with neuronal mechanisms, this particular epithelial location of TRPV1 is suggested to be involved in the regulation of gastric chlorhydropeptic secretion (Raybould and Tache, 1989;Horie et al, 2004;Faussone-Pellegrini et al, 2005).…”

Section: Trpv Channelsmentioning

confidence: 98%

TRP channels in neurogastroenterology: opportunities for therapeutic intervention

Boesmans

Owsianik

Tack

et al. 2010

British J Pharmacology

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The members of the superfamily of transient receptor potential (TRP) cation channels are involved in a plethora of cellular functions. During the last decade, a vast amount of evidence is accumulating that attributes an important role to these cation channels in different regulatory aspects of the alimentary tract. In this review we discuss the expression patterns and roles of TRP channels in the regulation of gastrointestinal motility, enteric nervous system signalling and visceral sensation, and provide our perspectives on pharmacological targeting of TRPs as a strategy to treat various gastrointestinal disorders. We found that the current knowledge about the role of some members of the TRP superfamily in neurogastroenterology is rather limited, whereas the function of other TRP channels, especially of those implicated in smooth muscle cell contractility (TRPC4, TRPC6), visceral sensitivity and hypersensitivity (TRPV1, TRPV4, TRPA1), tends to be well established. Compared with expression data, mechanistic information about TRP channels in intestinal pacemaking (TRPC4, TRPC6, TRPM7), enteric nervous system signalling (TRPCs) and enteroendocrine cells (TRPM5) is lacking. It is clear that several different TRP channels play important roles in the cellular apparatus that controls gastrointestinal function. They are involved in the regulation of gastrointestinal motility and absorption, visceral sensation and visceral hypersensitivity. TRP channels can be considered as interesting targets to tackle digestive diseases, motility disorders and visceral pain. At present, TRPV1 antagonists are under development for the treatment of heartburn and visceral hypersensitivity, but interference with other TRP channels is also tempting. However, their role in gastrointestinal pathophysiology first needs to be further elucidated.

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“…Moreover, capsaicin also markedly reduced the ability of SFLLRN-NH 2 TFLLR-NH 2 , and SLIGRL-NH 2 to evoke contractile responses. Capsaicin may cause desensitisation of the receptor VR1, expressed by some enteric neurones (Nozawa et al, 2001), blockade of voltage-gated calcium channels and other effects (Maggi, 1995). However, it is likely that in our preparation, exposed to high concentration of capsaicin for a prolonged time, capsaicin acts on sensory nerve fibres to release, and then to deplete, biologically active substances, such as tachykinins (Maggi, 1995).…”

Section: F Mulè Et Al Par-induced Release Of No and Tachykinins 601mentioning

confidence: 99%

Involvement of nitric oxide and tachykinins in the effects induced by protease‐activated receptors in rat colon longitudinal muscle

Mulè

Baffi

Capparelli

et al. 2003

British J Pharmacology

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1 The aim of the present study was to verify a possible involvement of nitric oxide (NO) and of tachykinins in the contractile and relaxant effects caused by the activation of protease-activated receptor (PAR)-1 and PAR-2 in the longitudinal muscle of rat colon. 2 Mechanical responses to the PAR-1 activating peptides, SFLLRN-NH 2 (10 nM -10 mM) and TFLLR-NH 2 (10 nM -10 mM), and to the PAR-2-activating peptide, SLIGRL-NH 2 (10 nM -10 mM), were examined in vitro in the absence and in the presence of different antagonists. The contractile responses to PAR-1 and PAR-2 activation were concentration-dependently attenuated by SR140333 (0.1 -1 mM), NK 1 receptor antagonist, or by SR48968 (0.1 -1 mM), NK 2 receptor antagonist. The combined pretreatment with SR140333 (1 mM) and SR48968 (1 mM) produced additive suppressive effects on the contractile responses to PAR activation. Pretreatment of the preparation with capsaicin (10 mM) markedly reduced the contractions evoked by SFLLRN-NH 2 , TFLLR-NH 2 and SLIGRL-NH 2 , while o-conotoxin GVIA (0.2 mM) had no effect. 5 The present results suggest that in rat colonic longitudinal muscle, PAR-1 and PAR-2 activation can evoke (i) relaxation through the production of NO or (ii) contraction through the release of tachykinins, likely, from sensory nerves. These actions may contribute to motility disturbances during intestinal trauma and inflammation.

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Distribution and characterization of vanilloid receptors in the rat stomach

Cited by 61 publications

References 16 publications

Representations of the Texture of Food in the Primate Orbitofrontal Cortex: Neurons Responding to Viscosity, Grittiness, and Capsaicin

Representations of the Texture of Food in the Primate Orbitofrontal Cortex: Neurons Responding to Viscosity, Grittiness, and Capsaicin

TRP channels in neurogastroenterology: opportunities for therapeutic intervention

Involvement of nitric oxide and tachykinins in the effects induced by protease‐activated receptors in rat colon longitudinal muscle

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