Distribution and characterization of Heterobilharzia americana in dogs in Texas

Rodriguez, Jessica Y.; Lewis, Barbara C.; Snowden, Karen F.

doi:10.1016/j.vetpar.2014.03.026

Cited by 26 publications

(52 citation statements)

References 31 publications

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“…The negative results of these tests argue against an underlying infection but do not preclude it because the histochemical techniques are relatively insensitive. Submucosal inflammatory lesions with marked dilations of the vessels associated with FLL are a feature of Heterobilharzia americana infection (Gerard Rodriguez & Snowden ). No flukes were detected within the resected tissues, and Heterobilharzia americana has not to our knowledge been reported as an infectious agent in dogs in France.…”

Section: Discussionmentioning

confidence: 99%

Focal intestinal lipogranulomatous lymphangitis in 10 dogs

Lecoindre

Lecoindre²,

Cadoré

et al. 2016

J of Small Animal Practice

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Section: Discussionmentioning

confidence: 99%

Focal intestinal lipogranulomatous lymphangitis in 10 dogs

Lecoindre

Lecoindre²,

Cadoré

et al. 2016

J of Small Animal Practice

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“…Copper‐associated and idiopathic CH are reviewed elsewhere. Granulomatous hepatitis is an uncommon form of CH in dogs and may be the result of infectious diseases such as schistosomiasis, histoplasmosis, Angiostrongylus vasorum infection, leishmaniasis, or with lymphoma and histiocytosis . Regardless of the underlying cause of CH, chronic inflammation leads to fibrosis.…”

Section: Causes Of Hepatic Fibrosis In Dogsmentioning

confidence: 99%

Hepatic Fibrosis in Dogs

Eulenberg

Lidbury

2017

Veterinary Internal Medicne

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Hepatic fibrosis is commonly diagnosed in dogs, often as a sequela to chronic hepatitis (CH). The development of fibrosis is a crucial event in the progression of hepatic disease that is of prognostic value. The pathophysiology of hepatic fibrosis in human patients and rodent models has been studied extensively. Although less is known about this process in dogs, evidence suggests that fibrogenic mechanisms are similar between species and that activation of hepatic stellate cells is a key step. Diagnosis and staging of hepatic fibrosis in dogs requires histopathological examination of a liver biopsy specimen. However, performing a liver biopsy is invasive and assessment of fibrotic stage is complicated by the absence of a universally accepted staging scheme in veterinary medicine. Serum biomarkers that can discriminate among different fibrosis stages are used in human patients, but such markers must be more completely evaluated in dogs before clinical use. When successful treatment of its underlying cause is feasible, reversal of hepatic fibrosis has been shown to be possible in rodent models and human patients. Reversal of fibrosis has not been well documented in dogs, but successful treatment of CH is possible. In human medicine, better understanding of the pathomechanisms of hepatic fibrosis is leading to the development of novel treatment strategies. In time, these may be applied to dogs. This article comparatively reviews the pathogenesis of hepatic fibrosis, its diagnosis, and its treatment in dogs.

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“…Although this disease is endemic in Texas, Louisiana, and Florida, isolated cases have been reported in North Carolina, Kansas, and Indiana. [1][2][3][4][5][6][7] Schistosomiasis is more commonly reported in medium to large breed dogs. 1,8 Presenting clinical signs include lethargy, hypo-or anorexia, weight loss, diarrhea with or without hematochezia or melena, vomiting, and polyuria/polydipsia.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7] Schistosomiasis is more commonly reported in medium to large breed dogs. 1,8 Presenting clinical signs include lethargy, hypo-or anorexia, weight loss, diarrhea with or without hematochezia or melena, vomiting, and polyuria/polydipsia. 1,5,[8][9][10][11] The vague clinical signs, variable in severity, can mimic numerous other conditions, both infectious and primarily inflammatory.…”

Section: Introductionmentioning

confidence: 99%

“…1,8 Presenting clinical signs include lethargy, hypo-or anorexia, weight loss, diarrhea with or without hematochezia or melena, vomiting, and polyuria/polydipsia. 1,5,[8][9][10][11] The vague clinical signs, variable in severity, can mimic numerous other conditions, both infectious and primarily inflammatory. A wide variety of clinicopathological abnormalities has been described in association with this disease: hyper-or hypocalcemia, hyper-or hyposphosphatemia, hypernatremia, hyper-or hypocholesterolemia, hyperglobulinemia, hypoalbuminemia, azotemia, anemia, eosinophilia or eosinopenia, and thrombocytopenia.…”

Section: Introductionmentioning

confidence: 99%

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Sonographic findings of pinpoint hyperechoic foci in the small intestine, liver, and mesenteric lymph nodes are indicative of canine Heterobilharzia americana infection

Moshnikova

Gilmour

Cook

et al. 2020

Vet Radiology Ultrasound

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Canine schistosomiasis, caused by the trematode Heterobilharzia americana, can pose a diagnostic challenge due to nonspecific symptoms. The aim of this multicenter, retrospective, descriptive study was to compare the prevalence and extent of sonographic changes associated with schistosomiasis between affected and infection‐free dogs. Medical records of two referral centers were searched for dogs with confirmed schistosomiasis that had undergone an abdominal ultrasound. Fifty‐five cases fulfilled the inclusion criteria, and a contemporaneous control group was derived from dogs that tested negative for H. americana. Two blinded reviewers evaluated the images. The majority of Heterobilharzia‐infected (further termed H‐pos) dogs (82%) had ultrasonographic abnormalities in the small intestine ± liver. Abnormal layering of the small intestine was noted in 38 of 54 H‐pos dogs, compared to six of 54 control dogs (P < .0001). Pinpoint hyperechoic foci were noted in the small intestinal submucosa or muscularis layers in 25 of 54 H‐pos dogs, but only three controls (P < .0001). Heterogeneity of the hepatic parenchyma and pinpoint hyperechoic foci were more prevalent in H‐pos dogs (65% vs 40%; P = .0213 and 44% vs 18%; P = .0068, respectively). Pinpoint hyperechoic foci within mesenteric lymph nodes were noted in seven H‐pos dogs and none of the controls (P = .0128). The combination of heterogeneous small intestine wall layering and pinpoint hyperechoic foci in small intestine, liver, or mesenteric lymph nodes was the most reliable indication of infection (P = .0001; odds ratio = 36.87), with positive predictive value of 94%, yet modest sensitivity for the detection of infection (58%). Observing these sonographic features suggests schistosomiasis and should prompt further testing.

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Distribution and characterization of Heterobilharzia americana in dogs in Texas

Cited by 26 publications

References 31 publications

Focal intestinal lipogranulomatous lymphangitis in 10 dogs

Focal intestinal lipogranulomatous lymphangitis in 10 dogs

Hepatic Fibrosis in Dogs

Sonographic findings of pinpoint hyperechoic foci in the small intestine, liver, and mesenteric lymph nodes are indicative of canine Heterobilharzia americana infection

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