Distribution and actions of orphanin in rat gastrointestinal tract

Takahashi, Takuya; Bagnol, Didier; Yazdani, Ali; Li, Y; Watson, SJ; Owyang, Chung

doi:10.1016/s0016-5085(98)83445-8

Cited by 4 publications

(1 citation statement)

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“…OFQ given intravenously to anesthetized rats has been shown to increase intragastric pressure (11). Similarly, OFQ given intravenously to rats (state of consciousness unknown) caused colonic contractions (34). All of the aforementioned studies reveal that OFQ has actions similar to those of endogenous and exogenous opioid compounds when tested in similar assays, with the important difference being that OFQ's actions are naloxone insensitive.…”

Section: Discussionmentioning

confidence: 96%

Peripheral and central actions of orphanin FQ (nociceptin) on murine colon

Osinski¹,

Bass

Gaumnitz

1999

American Journal of Physiology-Gastrointestinal and Liver Physi

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Orphanin FQ (OFQ), also known as nociceptin, is a recently isolated endogenous peptide with a structure similar to the endogenous opioid peptides. The present study examines the actions of centrally administered OFQ on in vivo murine gastrointestinal and colonic transit as well as the actions of OFQ on the isolated colon. Intracerebroventricular injections of OFQ dose dependently inhibited colonic propulsive activity. OFQ inhibition of colonic propulsion was unaffected by coadministration of the competitive opioid receptor antagonist naltrexone. A subadditive response was observed when approximately equipotent doses of either morphine sulfate or the δ-agonist DPDPE were coadministered with OFQ. No subadditivity was observed with coadministration of the μ-agonist DAMGO, suggesting a functional interaction between OFQ and δ-opioid central pathways regulating colonic transit. High, but not low, doses of OFQ also inhibited the transit of a nonabsorbable charcoal marker through the stomach and/or small intestine. OFQ potently contracted isolated colon preparations; contractile activity was abolished by TTX or chlorpromazine. Our results suggest that OFQ may be an important peptide ligand acting on a novel inhibitory neural pathway that modulates gastrointestinal transit.

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Section: Discussionmentioning

confidence: 96%