Distributed sensor and actuator networks for closed-loop bioelectronic medicine

Bhave, Gauri; Chen, Joshua; Singer, Amanda; Sharma, Aditi; Robinson, Jacob T.

doi:10.1016/j.mattod.2020.12.020

Cited by 21 publications

(15 citation statements)

References 125 publications

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“…Having bioelectronics implanted within the vasculature enables devices to be implanted in many parts of the body that are traditionally difficult to reach without having major risks of surgery. Additionally, bioelectronic implants with access to the bloodstream could enable real-time sensing of biochemicals, pH or oxygenation levels within the blood to provide diagnostics or support closed-loop-electronic medicine 57 , 58 . Overall, wirelessly powered mm-sized devices implanted within or near the vasculature could open up numerous opportunities for minimally invasive bioelectronic medicine.…”

Section: Discussionmentioning

confidence: 99%

A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves

et al. 2022

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Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals’ sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.

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Section: Discussionmentioning

confidence: 99%

A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves

et al. 2022

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“…Free from wire and tethers these networks could span large areas of tissue and coordinate multimodal sensory and simulation capabilities to provide precise regulation of physiological processes. [ 100 ] Indeed, bioelectronics empowered by a suite of wireless data and power transfer technologies is certain to usher in innovative minimally invasive and distributed systems for improving the way we understand and treat disease.…”

Section: Discussionmentioning

confidence: 99%

Wireless Power Delivery Techniques for Miniature Implantable Bioelectronics

Singer

Robinson

2021

Adv Healthcare Materials

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Progress in implanted bioelectronic technology offers the opportunity to develop more effective tools for personalized electronic medicine. While there are numerous clinical and pre‐clinical applications for these devices, power delivery to these systems can be challenging. Wireless battery‐free devices offer advantages such as a smaller and lighter device footprint and reduced failures and infections by eliminating lead wires. However, with the development of wireless technologies, there are fundamental tradeoffs between five essential factors: power, miniaturization, depth, alignment tolerance, and transmitter distance, while still allowing devices to work within safety limits. These tradeoffs mean that multiple forms of wireless power transfer are necessary for different devices to best meet the needs for a given biological target. Here six different types of wireless power transfer technologies used in bioelectronic implants—inductive coupling, radio frequency, mid‐field, ultrasound, magnetoelectrics, and light—are reviewed in context of the five tradeoffs listed above. This core group of wireless power modalities is then used to suggest possible future bioelectronic technologies and their biological applications.

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“…AI-enabled modeling and simulation are promising tools to improve data interpretation and distinguish between changes that are caused by a disease from those that cause the disease. Next-generation systems biology will undoubtedly benefit from AI methods capable of converting multi-omics data at different scales into actionable knowledge (Nielsen, 2017;Angione, 2019), especially considering the expected advances in data collection from patients (e.g., biosensors for measuring the concentration of chemical species from body fluids) (Jin et al, 2020;Bhave et al, 2021;Phatak et al, 2021). In turn, personalized datasets are poised to substantially enhance the ability of AI for parametrizing quantitative systems pharmacology (QSP) models that combine systems biology with pharmacokinetics and pharmacodynamics (PK/PD) in order to find optimized therapeutics for individual patients or populations with a given disease [for example, see (McEwen et al, 2021)].…”

Section: Discussionmentioning

confidence: 99%

How artificial intelligence enables modeling and simulation of biological networks to accelerate drug discovery

DiNuzzo¹

2022

Front. Drug. Discov.

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The pharmaceutical industry suffered a significant decline of innovation in the last few decades, whose simple reason is complex biology. Artificial intelligence (AI) promises to make the entire drug discovery and development process more efficient. Here I consider the potential benefits of using AI to deepen our mechanistic understanding of disease by leveraging data and knowledge for modeling and simulation of genome-scale biological networks. I outline recent developments that are moving the field forward and I identify several overarching challenges for advancing the state of the art towards the successful integration of AI with modeling and simulation in drug discovery.

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Distributed sensor and actuator networks for closed-loop bioelectronic medicine

Cited by 21 publications

References 125 publications

A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves

A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves

Wireless Power Delivery Techniques for Miniature Implantable Bioelectronics

How artificial intelligence enables modeling and simulation of biological networks to accelerate drug discovery

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