Distributed neural systems for temporal production: A functional MRI study

Basso, Gianpaolo; Nichelli, Paolo Frigio; Wharton, Charles M.; Peterson, Matthew R.; Grafman, Jordan

doi:10.1016/s0361-9230(02)00941-3

Cited by 50 publications

(28 citation statements)

References 43 publications

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“…Studies also indicate dysfunctions in frontal and frontostriatal circuits in substance dependence [15,97]. Neuroimaging studies have shown that EF tasks similar to those used in our study activate a variety of areas within the prefrontal cortex [28,31,98] and in addition to this, activate areas with important connections to the prefrontal cortex, such as the caudate nucleus, the putamen, thalamic areas [30], cingulate and parietal cortex [29,99]. The deficits in EFs as found in our PG and AD group are therefore likely to be associated with dysfunctions of these brain structures and brain circuits.…”

Section: Discussionsupporting

confidence: 60%

Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls

et al. 2006

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Aims Neurocognitive functions in pathological gambling have relevance for the aetiology and treatment of this disorder, yet are poorly understood. This study therefore investigated neurocognitive impairments of executive functions in a group of carefully screened Diagnostic and Statistical Manual version IV (DSM-IV-TR) pathological gamblers. Performance was compared to a group of normal control participants. To study the specificity of these neurocognitive deficits, a substance dependence group (alcohol dependence) and an impulse control disorder group (Tourette syndrome) were included. Design Cross-sectional study. Setting Addiction and general mental health treatment centres. Participants Forty-nine pathological gamblers, 48 abstinent alcohol-dependent patients, 46 participants with Tourette syndrome and 49 normal control participants. Measurements A comprehensive neuropsychological battery measuring executive functions as well as basic cognitive functions. Findings Both the pathological gambling and the alcohol dependent groups were characterized by diminished performance on inhibition, time estimation, cognitive flexibility and planning tasks. The Tourette syndrome group showed deficits only on inhibition tasks. Basic cognitive functions were intact in all clinical groups. Comorbid attention deficit hyperactivity disorder, antisocial personality disorder and nicotine dependence influenced the impaired functions of the clinical groups only minimally. Conclusions Carefully screened groups of pathological gamblers and alcohol dependents were characterized by diminished executive functioning, suggesting a dysfunction of frontal lobe circuitry in these disorders. The resemblance between the pathological gambling group and the alcohol dependence group suggests a common neurocognitive aetiology for these disorders. Psychosocial treatment of these disorders could benefit from assessing and targeting deficits in executive functions, as they probably influence the course of these disorders negatively.

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Section: Discussionsupporting

confidence: 60%

Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls

et al. 2006

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“…Consistently increasing evidence shows that the SMA is activated by perceptual procedures and supra-second intervals (Lewis and Miall 2003b;Smith et al 2003) even though motor temporal procedures are more often used, generally with shorter temporal ranges (Cesara et al 2005;Elsinger et al 2003;Jantzen et al 2002;Kudo et al 2004;Lewis et al 2004;Mayville et al 2002), but occasionally with very long ones Hinton and Meck 2004). Not surprisingly, no SMA activation is observed when two conditions that both include explicit or implicit timing are contrasted (Basso et al 2003;Harrington et al 2004;Kudo et al 2004;Mathiak et al 2004).…”

Section: Discussionmentioning

confidence: 93%

The supplementary motor area in motor and perceptual time processing: fMRI studies

Macar

Coull

Vidal³

2006

Cogn Process

132

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The neural bases of timing mechanisms in the second-to-minute range are currently investigated using multidisciplinary approaches. This paper documents the involvement of the supplementary motor area (SMA) in the encoding of target durations by reporting convergent fMRI data from motor and perceptual timing tasks. Event-related fMRI was used in two temporal procedures, involving (1) the production of an accurate interval as compared to an accurate force, and (2) a dual-task of time and colour discrimination with parametric manipulation of the level of attention attributed to each parameter. The first study revealed greater activation of the SMA proper in skilful control of time compared to force. The second showed that increasing attentional allocation to time increased activity in a cortico-striatal network including the pre-SMA (in contrast with the occipital cortex for increasing attention to colour). Further, the SMA proper was sensitive to the attentional modulation cued prior to the time processing period. Taken together, these data and related literature suggest that the SMA plays a key role in time processing as part of the striato-cortical pathway previously identified by animal studies, human neuropsychology and neuroimaging.

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“…Involvement of the DLPFC in timing has been observed across a wide range of timing tasks, from duration perception (Rao et al 2001;Lewis and Miall 2003;Smith et al 2003) to interval time estimation (Macar et al 2002;Basso et al 2003) and motor timing (Rubia et al 1998;Jancke et al 2000). The specific role of the DLPFC in timing, however, is not clearly understood.…”

Section: Discussionmentioning

confidence: 99%

Temporal Processing in Schizophrenia: Effects of Task-Difficulty on Behavioral Discrimination and Neuronal Responses

Davalos¹,

Rojas²,

Tregellas³

2008

Schizophrenia Research

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Distributed neural systems for temporal production: A functional MRI study

Cited by 50 publications

References 43 publications

Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls

Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls

The supplementary motor area in motor and perceptual time processing: fMRI studies

Temporal Processing in Schizophrenia: Effects of Task-Difficulty on Behavioral Discrimination and Neuronal Responses

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