Distributed Anatomy of Transcortical Sensory Aphasia

Alexander, Michael P.; Hiltbrunner, Beat; Fischer, Richard S.

doi:10.1001/archneur.1989.00520440075023

Cited by 139 publications

(64 citation statements)

References 22 publications

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“…In contrast to the patients with semantic dementia, the cortical localization for this syndrome has been attributed to inferior parietal and posterior temporal cortex (Alexander et al, 1989;Berthier, 1999). Based on our data, a more precise location may be the left TOP junction.…”

Section: Discussionmentioning

confidence: 99%

A Common System for the Comprehension and Production of Narrative Speech

Awad

Warren²,

Scott³

et al. 2007

J. Neurosci.

131

104

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Humans devote much time to the exchange of memories within the context of shared general and personal semantic knowledge. Our hypothesis was that functional imaging in normal subjects would demonstrate the convergence of speech comprehension and production on high-order heteromodal and amodal cortical areas implicated in declarative memory functions. Activity independent of speech phase (that is, comprehension and production) was most evident in the left and right lateral anterior temporal cortex. Significant activity was also observed in the posterior cortex, ventral to the angular gyri. The left and right hippocampus and adjacent inferior temporal cortex were active during speech comprehension, compatible with mnemonic encoding of narrative information, but activity was significantly less during the overt memory retrieval associated with speech production. Therefore, although clinical studies suggest that hippocampal function is necessary for the retrieval as well as the encoding of memories, the former appears to depend on much less net synaptic activity. In contrast, the retrosplenial/posterior cingulate cortex and the parahippocampal area, which are closely associated anatomically with the hippocampus, were equally active during both speech comprehension and production. The results demonstrate why a severe and persistent inability both to understand and produce meaningful speech in the absence of an impairment to process linguistic forms is usually only observed after bilateral, and particularly anterior, destruction of the temporal lobes, and emphasize the importance of retrosplenial/posterior cingulate cortex, an area known to be affected early in the course of Alzheimer's disease, in the processing of memories during communication.

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Section: Discussionmentioning

confidence: 99%

A Common System for the Comprehension and Production of Narrative Speech

Awad

Warren²,

Scott³

et al. 2007

J. Neurosci.

131

104

View full text Add to dashboard Cite

show abstract

“…The dorsomedial thalamus (Squire and Moore 1979), the superior/posterior thalamic peduncles, the mamillothalamic tracts (von Cramon 1985, Gentilini et al 1987, and anterior intrathalamic fiber projections (Plets et al 1970, von Cramon 1985, Kritchevsky et al 1987) have all been implicated. Some investigators suggest that the language problems seen in adults after thalamic injury reflect predominantly memory problems or semantic-memory access, rather than language function alone (Wallesch et al 1983, Crossen 1984, Wallesch and Papagno 1988, Alexander et al 1989, Nadeau and Crosson 1997.…”

Section: Discussionmentioning

confidence: 99%

Acquired aphasia in children after surgical resection of left‐thalamic tumors

Nass¹,

Boyce²,

Leventhal³

et al. 2000

Develop Med Child Neuro

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Five children (three males, two females; four right‐, one left‐handed; age range 6 to 14 years) who developed aphasia after gross‐total excision of left predominantly thalamic tumors are reported. Three patients had Broca aphasia, one had mixed transcortical aphasia, and one patient had conduction aphasia. In the months after surgery, three children improved while receiving radiation and/or chemotherapy, although none recovered completely. Two patients with malignant tumors developed worsening aphasia when the tumor recurred, and later died. Two of three patients tested had visuospatial difficulties in addition to language deficits. Attention and executive functioning were affected in three of three patients tested. Memory, verbal and/or visual functioning, were affected in four of four patients tested. Both patients who were tested showed transient right hemineglect. Two of two patients tested were probably apraxic. The wide range of deficits in these children highlights the importance of the thalamus and other subcortical structures in developing cognition.

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“…The stroke literature emphasizes the role of posterior heteromodal cortex in language comprehension (Geschwind, 1965;Kertesz et al, 1982;Alexander et al, 1989). A number of human functional imaging studies support this position, by demonstrating activation in posterior temporal or inferior parietal cortex in response to lexical or semantic tasks (for review, see Binder et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Converging Language Streams in the Human Temporal Lobe

et al. 2006

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There is general agreement that, after initial processing in unimodal sensory cortex, the processing pathways for spoken and written language converge to access verbal meaning. However, the existing literature provides conflicting accounts of the cortical location of this convergence. Most aphasic stroke studies localize verbal comprehension to posterior temporal and inferior parietal cortex (Wernicke's area), whereas evidence from focal cortical neurodegenerative syndromes instead implicates anterior temporal cortex. Previous functional imaging studies in normal subjects have failed to reconcile these opposing positions. Using a functional imaging paradigm in normal subjects that used spoken and written narratives and multiple baselines, we demonstrated common activation during implicit comprehension of spoken and written language in inferior and lateral regions of the left anterior temporal cortex and at the junction of temporal, occipital, and parietal cortex. These results indicate that verbal comprehension uses unimodal processing streams that converge in both anterior and posterior heteromodal cortical regions in the left temporal lobe.

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Distributed Anatomy of Transcortical Sensory Aphasia

Cited by 139 publications

References 22 publications

A Common System for the Comprehension and Production of Narrative Speech

A Common System for the Comprehension and Production of Narrative Speech

Acquired aphasia in children after surgical resection of left‐thalamic tumors

Converging Language Streams in the Human Temporal Lobe

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