Distribución heterogénea de la prevalencia de anticuerpos contra Trypanosoma cruzi en donadores de sangre en Puebla, México

Monteón, Vı́ctor; Reyes-López, Pedro Antonio; Sosa-Palacio, Adalid; León-Tello, Gloria; Martínez-Murguía, Jaime; Sosa-Jurado, Francisca

doi:10.1590/s0036-36342005000200005

Cited by 13 publications

(4 citation statements)

References 7 publications

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“…Overall, the HBsAg prevalence in blood donors was 0.066% throughout the studied period, which is below the range reported by most studies of blood donors during the last decade in several Mexican states: 0.23% (15), 0.30% (16), 0.20% (17), 0.18% (18), 0.057% (19), and 0.216% (20). In these studies, the presence of anti-HBc was not analyzed; however, the overall anti-HBc prevalence of 1.19% was lower than that found in two other studies of Mexican blood donors (4.42% (6) and 1.82% (7)) and almost one third of the 3.3% prevalence reported for Mexican adults with different socioeconomic status (4).…”

Section: Discussioncontrasting

confidence: 57%

Prevalence of Serologic Hepatitis B Markers in Blood Donors From Puebla, Mexico: The Association of Relatively High Levels of Anti-Core Antibodies With the Detection of Surface Antigen and Genomic DNA

et al. 2016

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Background: The hepatitis B virus (HBV) causes chronic hepatitis, hepatic cirrhosis, and hepatocellular carcinoma. Surface antigen (HBsAg) detection is a definitive test that can confirm HBV infection, while the presence of antibodies against the core protein (antiHBc) suggests either a previous or ongoing infection or occult hepatitis B infection (OBI). Objectives: The aim of the present study was to determine the prevalence of anti-HBc and HBsAg in blood donors. Further, the study aimed to estimate the anti-HBc level at which HBV DNA is detected in putative OBI cases, as well as to search for mutations in the "a" determinant associated with the non-detection of HBsAg in serum. Patients and Methods: We conducted a cross-sectional study from [2003][2004][2005][2006][2007][2008][2009]. The study included 120,552 blood donors from the state of Puebla, Mexico. Different commercial systems based on microparticles (enzymatic (MEIA) or chemiluminescent (CMIA)) were used to determine the HBsAg and anti-HBc levels. For the detection of HBV DNA, a nested polymerase chain reaction (nested PCR) was used and the genotypes were determined using Sanger sequencing. Results: Of the 120,552 blood donors, 1437 (1.19%, 95% CI: 1.12 -1.26) were reactive to anti-HBc, while 82 (0.066%, 95% CI: 0.053 -0.079) were reactive to HBsAg. Some 156 plasma samples collected in 2009 from anti-HBc-positive/HBsAg-negative blood donors were submitted for HBV DNA detection in a search for probable OBI. Viral DNA was detected in 27/156 (17.3%, 95% CI: 11.5 -23.1). Our results show

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Section: Discussioncontrasting

confidence: 57%

Prevalence of Serologic Hepatitis B Markers in Blood Donors From Puebla, Mexico: The Association of Relatively High Levels of Anti-Core Antibodies With the Detection of Surface Antigen and Genomic DNA

et al. 2016

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“…The prevalence found in this study is lower than that reported by the ENSE in the 80´s when the prevalence of seropositivity for T. cruzi was 3.2% in Hidalgo (Monteón et al, 2005).…”

Section: Discussioncontrasting

confidence: 80%

Hyperglycemia associated with Chagas disease

Armenta¹,

Rodriguez²,

Pérez³

et al. 2022

mbr

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Chagas disease and type 2 diabetes mellitus are the two main causes of Years Lived with Disability. The consequences and possible interaction between both illnesses have been scarcely studied. A population study of blood donors from the Centro Estatal de Transfusión Sanguinea (CETS) was carried out with a reagent related to the Chagas test. Detection was carried out with an enzyme-linked immunosorbent assay (ELISA) of anti- Trypanosoma cruzi antibodies and also, an HbA1C test was performed with 4 mL of whole blood. Descriptive statistics were used to analyze quantitative and qualitative data. The Chi-square test was applied to determine the existence of an association between hyperglycemia and Chagas disease. A total of 4,952 participants were screened. All of the participants (100%) were from Hidalgo State and did not have a chagoma as evidence of having been bitten or denied contact with a “kissing bug”. Of the total, 26 reacted to the first screening test to detect anti-Trypanosoma cruzi antibodies; of these, five were confirmed as positive on the second screening test. The seroprevalence of T. cruzi was 0.01%. The results do not show a clear association but the frequency of hyperglycemia in population with Chagas coincides with that reported by other authors. Considering the scarce clinical–epidemiological evidence between Chagas disease, obesity, and hyperglycemia, long-term follow up of both morbidities is an area of opportunity for clinical and epidemiological study of T. cruzi reactivity.

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“…The variable age has been found in studies developed in Brazil, Argentina, Bolivia, Colombia, Spain, Ecuador, Mexico, Peru, and Venezuela. For being a silent disease that reveals its symptoms only in 10 to 30 years after the protozoan infection [3], in most research, age is found in a directly proportional relation to the CD diagnosis, that is, older people have more probability of discovering the infection [31,53,101,115,[124][125][126][127][128][129][130].…”

Section: ➢ Agementioning

confidence: 99%

Predictor Variables in the Spread of Chagas Disease in Rural Areas

de Sousa Leite,

de Rezende Feres,

Scalize

2024

Pathogens

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Over a hundred years ago after the discovery of Chagas disease (CD) in Brazil, the World Health Organization estimates a number of 6 to 7 million people infected by Trypanosoma cruzi worldwide. Therefore, the goal of this work was to identify variables related to the spread of infection by T. cruzi in humans living in rural areas, seeking predictor variables. A systematic review of the literature has been conducted, with a search in the Scopus platform, using the search string “Chagas disease” and “rural”, resulting in 85 valid and analyzed scientific studies (1977 and 2022). Twenty-seven predictor variables have been acquired, and 19 of them have been grouped, such as: socioeconomic and educational, housing, environmental, sanitary, and cultural; and 8 variables related to T. cruzi seropositive individuals. The predictor variables yielded significant results (p-value < 0.05) in 59.5% of the cases (195/328), with a median of 66.7%. In other words, studies relating to 50% of the 27 variables showed significance equal to or greater than 66.7% of the time. The independent variables with the highest proportion of significant data (p-value < 0.05) were Education (87.6%), Intradomicile building (70%), Domestic animals (69.6%), and Triatomines (69.2%) in the households. Some variables reached 100%; however, few articles were found, indicating the need for further research, especially for Sanitation and Culture. It has been concluded that, in the several contexts found, the social vulnerability and lack of information led the individual to living in environments where inhabitability is inadequate, to perform limited work activity and develop habits and behaviors which impair them in an environmental insalubrity situation, favorable to the access of vectors and pathogens of anthropozoonoses such as CD.

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Distribución heterogénea de la prevalencia de anticuerpos contra Trypanosoma cruzi en donadores de sangre en Puebla, México

Abstract: T. cruzi seroprevalence distribution is heterogeneous, from 0% to 2.6%, with higher seroprevalences in the regions of Tehuacan-Sierra Negra and Mixteca.

Cited by 13 publications

References 7 publications

Prevalence of Serologic Hepatitis B Markers in Blood Donors From Puebla, Mexico: The Association of Relatively High Levels of Anti-Core Antibodies With the Detection of Surface Antigen and Genomic DNA

Prevalence of Serologic Hepatitis B Markers in Blood Donors From Puebla, Mexico: The Association of Relatively High Levels of Anti-Core Antibodies With the Detection of Surface Antigen and Genomic DNA

Hyperglycemia associated with Chagas disease

Predictor Variables in the Spread of Chagas Disease in Rural Areas

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