Distress improves after mindfulness training for progressive MS: A pilot randomised trial

Bogosian, Angeliki; Chadwick, Paul; Windgassen, Sula; Norton, Sam; McCrone, Paul; Mosweu, Iris; Silber, Eli; Moss‐Morris, Rona

doi:10.1177/1352458515576261

Cited by 125 publications

(199 citation statements)

References 43 publications

(70 reference statements)

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“…Such factors may serve as a practical barrier to participation in research studies, highlighting the important point that MBIs may need to be adapted to make them more suitable for the wide and varied population of people with MS. For example, the majority of studies thus far have included participants who score at or below 6 on the expanded disability status scale (EDSS) (able to walk up to 100m with a walking aid), and most of these individuals have had relapsing−remitting phenotypes (RRMS). 5 Very little is thus known about if or how MBIs might help people with progressive phenotypes, or with more severe disabilities.In their randomised controlled trial, Bogosian et al 10 can be seen to extend the boundaries defined above. The authors report on a novel and innovative approach to delivering an MBI specifically for people with progressive MS.…”

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confidence: 99%

“…In their randomised controlled trial, Bogosian et al 10 can be seen to extend the boundaries defined above. The authors report on a novel and innovative approach to delivering an MBI specifically for people with progressive MS.…”

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confidence: 99%

“…The key findings from the Bogosian et al 10 There are some interesting points to consider here. Firstly, because this study used an online classroom, the researchers were able to recruit nationally -this has notable implications for resource allocation in a financially constrained, nationalised health service, such as that in the UK.…”

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“…Bogosian et al 10 have added substantially to the empirical literature on the use of MBIs in people with MS and it is important that these preliminary findings are followed up in a definitive trial, ideally with an active control comparison group -a common criticism of the mindfulness literature in general. Important as these findings are, we need to hear more from those that matter most in this story -people with MS. Qualitative research, which can be nested within trials, could help answer such questions as: how do people with MS find mindfulness, what works for them, and why, as well as what aspects, if any, are unhelpful?…”

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Mindfulness-based interventions for people with multiple sclerosis

2015

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Mindfulness-based interventions (MBIs) are increasingly being applied in healthcare settings around the world, in particular as a means of managing stress in those with chronic conditions. Various meta-analyses examining their use in this area have been conducted over the past decade, all of which suggest some benefit, but in general there is a notable call for more rigorous research, to include both active control groups, and a wider demographic spread. 1,2,3 The highestquality evidence for MBIs is for the use of mindfulness-based cognitive therapy (MBCT) in the treatment of those with recurrent depression, and this is reflected in national clinical guidelines for the condition. 4 The use of MBIs in the multiple sclerosis (MS) population has not been widely studied. A recent systematic review demonstrated a relative paucity of high-quality research, with evidence for effectiveness being limited to improvements in measures for anxiety, depression, health-related quality of life, standing balance, and fatigue. 5 The UK National Institute for Clinical Excellence (NICE) now includes the recommendation of MBIs as one potential treatment for fatigue. 6 A major issue concerning the use of MBIs in healthcare settings is that, despite various models, there is no consensus definition on the construct of mindfulness itself, and further, no one is really sure how they work. MBIs originally derive from a combination of Buddhist meditation practices and Hatha Yoga postures, both of which are believed to have quite distinct neural mechanisms, although there is a degree of overlap, with attention regulation systems playing a prominent role. 7 Professor Jon Kabat-Zinn, who introduced their use in clinical settings in the 1980s, has defined mindfulness as: 'paying attention in a particular way: on purpose, in the present moment, and nonjudgementally'. 8 Typically, MBIs are delivered in a standard group format, with core content focusing on the development of 'mindfulness' through breath awareness, body awareness, and mindful movement. 8 Deconstructing MBIs to systematically tease apart their active ingredients has not yet been achieved, although recent evidence from an MBCT dismantling trial calls into question whether the meditation practices exert any additional benefit over and above the cognitive content of the course for the treatment of recurrent depression. 9 In the case of MS, it may also be important to ask what works, given the wide range of symptoms and disability levels that may otherwise limit participation in the 'core' mindfulness practices. Both cognitive impairment and physical disability are common amongst people with MS. Such factors may serve as a practical barrier to participation in research studies, highlighting the important point that MBIs may need to be adapted to make them more suitable for the wide and varied population of people with MS. For example, the majority of studies thus far have included participants who score at or below 6 on the expanded disability status scale (EDSS) (able to walk up to 1...

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Mindfulness-based interventions for people with multiple sclerosis

2015

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“…In this context, where ongoing disease management is required, technology assisted interventions offer a viable and important support option. Many eHealth solutions have been developed for a variety of chronic illnesses, including, diabetes [27,28], breast cancer [29], hypertension [30], cardiovascular disease [16], multiple sclerosis [31], headache [8] and chronic pain [12,14,32,33,34,35,36,37,38].…”

Section: Introduction Ehealthmentioning

confidence: 99%

An Evaluation of the Effectiveness of the Modalities Used to Deliver Electronic Health Interventions for Chronic Pain: Systematic Review With Network Meta-Analysis (Preprint)

Slattery¹,

Haugh²,

O’Connor³

et al. 2018

Preprint

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Abstract:Background: eHealth is the use of information and communication technology in the context of healthcare and health research. Recently, there has been a rise in the number of eHealth modalities and the frequency in which they are used to deliver technology-assisted self-management interventions for people living with chronic pain. However, there has been little or no research directly comparing these eHealth modalities. Objective:The aim of the current systematic review with a network meta-analysis is to directly compare the effectiveness of eHealth modalities in the context of chronic pain. Methods:Randomised controlled trials (N>20 per arm) that investigated technologically delivered interventions for adults with chronic pain were included. Data were extracted on pain severity, psychological distress and HRQoL, and the risk of bias was assessed. Studies were classified by their primary mode of delivery. Pair-wise meta-analyses were undertaken and a network meta-analysis was conducted to generate indirect comparisons of modalities for reducing pain severity. Results:The search returned 18,470 studies with 18,349 excluded (duplicates [2,310]; title and abstract [16,039]). Of the remaining papers, 30 studies with 4,595 randomised participants were included in the review. Rankings tentatively indicate that telephone supported interventions are the most effective, with a 46% chance that telephone intervention was the best modality, followed by studies delivered via interactive voice response, internet and virtual reality. Conclusions:This current systematic review with a network meta-analysis generated comparisons between previously un-compared technological modalities to determine which delivered the most effective interventions for the reduction of pain severity in chronic pain patients. There are limitations with this review; in particular, the underrepresented nature of some eHealth modalities included in the analysis. However, in the event that the review is regularly updated a clear ranking of eHealth modalities for the reduction of pain severity will emerge.

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Non-pharmacological Approaches Based on Mind-Body Medicine to Enhancement of Cognitive and Brain Reserve in Humans

Crescentini

Feruglio

2023

Contemporary Clinical Neuroscience

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Distress improves after mindfulness training for progressive MS: A pilot randomised trial

Abstract: This is the accepted version of the paper.This version of the publication may differ from the final published version. Permanent

Cited by 125 publications

References 43 publications

Mindfulness-based interventions for people with multiple sclerosis

Mindfulness-based interventions for people with multiple sclerosis

An Evaluation of the Effectiveness of the Modalities Used to Deliver Electronic Health Interventions for Chronic Pain: Systematic Review With Network Meta-Analysis (Preprint)

Non-pharmacological Approaches Based on Mind-Body Medicine to Enhancement of Cognitive and Brain Reserve in Humans

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