Distortion Product Otoacoustic Emissions in Healthy Newborns: Normative Data

Marco, J; Ventura, Antonio; Caballero, Javier Martínez; Paredes, Carlos; Brinés, J

doi:10.3109/00016489509139288

Cited by 14 publications

(11 citation statements)

References 13 publications

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“…One should therefore be careful with the interpretation of the comparisons made. Due to differences in the stimulus level of the primaries used, our present values cannot be compared with those obtained by Marco et al (1995). Furthermore, in none of these papers was an eventual interaction effect found as observed in our present study.…”

Section: Discussioncontrasting

confidence: 80%

“…However, unlike Engdahl et al (1994), we did not retest the babies, that failed the ®rst test, later the same or the next day. Dif®culties in recording DP at 0.5 kHz are attributed by Marco et al (1995) to the fact that surrounding noise is more elevated in the lower frequencies (0.7±1 kHz). These dif®culties are probably enhanced by probe ®tting problems in a study population as young as the present one: airtight sealing of the probe is hampered by the small size and elasticity of the ear canal.…”

Section: Discussionmentioning

confidence: 99%

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Reference data for DPOAE in healthy newborns

Gordts

Naessens

Mudde

et al. 2000

Scandinavian Audiology

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Distortion Product Otoacoustic Emissions (DPOAE) can be used as an alternative to Transient Evoked Otoacoustic Emissions (TEOAE). This study aims to establish normal values for DPOAE in healthy newborns. DPOAE were determined with the Madsen Celesta 503 at 0.5, 1, 2, 4 and 8 kHz with an unequal stimulus level of the primaries (L1 = 65 dB SPL, L2 = 50 dB SPL). DPOAE were present in 92.4% of the ears of the 185 babies tested at 4 days after birth. The 5% quantile and the median of the DPOAE of the right and left ears were calculated for the five frequencies tested. At 4 kHz there was a significant sex effect (mean amplitude of DPOAE was higher in female than in male babies) and at 2 kHz a significant interaction effect was found between sex and side. The calculated reference limits are open to comparison with data obtained using other commercial equipment.

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Section: Discussioncontrasting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Reference data for DPOAE in healthy newborns

Gordts

Naessens

Mudde

et al. 2000

Scandinavian Audiology

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“…Approximately 10% of the responses of the P1 and P2 datasets and 5% of the responses of the P3 dataset presented what we might call a DP-gram notch pattern. Similar observations have been presented in a previous study by Marco et al [1995], where neonatal DPOAEs were described as presenting peaks at 2.0 and 5.0 kHz and 'valleys or notches' in between. Representative responses of the notch in the DP-gram are shown in figure 3 .…”

Section: Discussionsupporting

confidence: 75%

Optimizing Otoacoustic Emission Protocols for a UNHS Program

Hatzopoulos

Petruccelli²,

Ciorba³

2008

Audiol Neurotol

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Objective: To identify the optimal test protocol to screen for hearing problems in newborns, an evaluation of three distortion product otoacoustic emission (DPOAE) protocols was conducted in neonates, from a well-baby nursery (WBN) and from a neonatal intensive care unit (NICU) and compared to the performance in newborns of a more standard protocol based on transient-evoked OAEs (TEOAEs). Methods: The DPOAE protocols used asymmetrical stimulus intensities (L₁ > L₂) with a frequency ratio of 1.22, in the following format: (P1), L₁ = 60, L₂ = 50 dB SPL; (P2), L₁ = 65, L₂ = 55 dB SPL, and (P3), L₁ = 75, L₂ = 65 dB SPL. Linear TEOAE responses, evoked by click stimuli of 75 dB peSPL, were used as controls of normal cochlear function. Five frequencies at 1.5, 2.0, 3.0, 4.0 and 5.0 kHz were tested with a common commercially available macro-based software subroutine (Otodynamics Corp, ILO-92). The project evaluated the responses from 1200 WBN infants (average age 48 h) and 350 low-birth-weight NICU infants, all randomly selected. Results: Statistical analyses comparing the signal-to-noise ratios (S/N), at the predefined f₂ frequencies, indicated that the P1 and P2 DPOAE protocols generated similar responses. Significant S/N differences were observed in the P3 to P2 dataset comparisons. DPOAE scoring criteria were estimated from the P3 dataset using a one-sided, distribution-free confidence intervals. The scoring criteria for a ‘pass’ were estimated as a minimum S/N of 6.0, 7.0 and 6.0 dB at 2.0, 3.0 and 4.0 kHz, respectively. In terms of feasibility, the P3 protocol generated responses in 98% of the WBN and 94.8% of the NICU infants. Conclusions: All three DPOAE protocols demonstrated shorter time-recording requirements than the standard TEOAE test. The false-positive and false-negative rates for the NICU infants were estimated as 0.0028 and 0.003%, respectively.

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“…Marco et al (1995) noted two “peaks” of maximum response level, one at 2000 Hz and one at 5000 to 6000 Hz with a reduction in response level at mid to high frequencies. This trough in the DP-gram is observed in adults as well, but typically at slightly lower frequencies (Lasky, et al, 1992; Smurzynski, et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Changes in the DP-Gram During the Preterm and Early Postnatal Period

2008

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Objectives-To describe and define changes in the infant DP-gram during an age continuum from the preterm period through the first 6 mo of postnatal life. This information provides normative guidelines for audiologists or hearing screeners using DPOAEs to monitor infant hearing status.Design-In this retrospective study, 2f 1 − f 2 DP-grams (DPOAE level × f 2 ) were recorded with primary tones at 65/55 dB SPL, f 2 /f 1 = 1.2, and f 2 frequencies ranging from 1500 to 9000 Hz. Results from one ear of 290 healthy infants ranging in age from 31 wks postconceptional age to 6-mo-old were examined. Data were collected using both longitudinal design (repeated tests on the same infant over time) and cross-sectional methodology (a different group of subjects representing each age category). Subjects were divided into three groups according to age and experimental design. The effects of age and frequency on DPOAE level were analyzed in the three groups separately.Results-The combined results from the three databases indicate that (1) DPOAE level increased for mid-frequencies throughout the preterm period, from 31 to 33 wks until the time period associated with term birth. This change was significant for 4500 and 6000 Hz; (2) DPOAE level decreased as f 2 frequency increased. In many infants, a shallow trough was observed with peak amplitude at 1500 Hz, a reduction in response amplitude through 4500 Hz, and a second peak around 6000 Hz; (3) during the postnatal period from birth through 6 mo, DPOAE level did not change significantly as a function of age and the DP-gram was relatively flat across f 2 frequency; and (4) infants showed mean DPOAE levels that were 4 to 12 dB higher than adult levels. Conclusions-The results indicate a frequency-dependent increase in DPOAE level during the preterm period in human infants. After birth, there is little change in amplitude through 6 mo. The infant DPOAE remains larger than adult amplitude at all ages tested, as shown in other reports, well into childhood, suggesting continued changes in DPOAE level during the first decade of life. Recent research suggests that immaturities of the conductive pathway may account for infant-adult differences in DPOAE level; however, it is not yet clear whether other sources contribute.

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Distortion Product Otoacoustic Emissions in Healthy Newborns: Normative Data

Cited by 14 publications

References 13 publications

Reference data for DPOAE in healthy newborns

Reference data for DPOAE in healthy newborns

Optimizing Otoacoustic Emission Protocols for a UNHS Program

Changes in the DP-Gram During the Preterm and Early Postnatal Period

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