Distortion product otoacoustic emission for the screening of cochlear damage in children treated with cisplatin

Abstract

DPOAE testing appears to be a more sensitive method to detect cochlear damage than conventional pure-tone audiometry. Our results suggest that the measurement of DPOAE thresholds is a useful approach to detect the early auditory changes induced by cisplatin therapy.

Early ototoxic changes in patients with germ cell tumor after first cycle of cisplatin‐based therapy

“…Unfortunately, the number of ototoxic cases was not reported in all studies (69%). The median (mean) of observed ototoxic cases is 63% (57%), a value very similar to that found by us (62%). The criteria used for ototoxicity is not uniform because there is no universally accepted criterion for ototoxic change in DPOAE; nonetheless, several authors of articles from the last 5 years, including our study, used a threshold, particularly one suggested by Beattie et al for the DPOAE amplitude shift.…”

“…Only a few studies aimed to specifically clarify the ototoxicity of cisplatin after the first cycle of treatment. All found statistically significant amplitude shift of DPOAE; however, only two articles presented the number of affected patients (50% and 73%) . The other authors investigated the role of cisplatin dose or continuously tested the DPOAE levels during the whole treatment.…”

“…Aside from the subjective hearing tests, the DPOAE measurements were performed before and after each treatment cycle. DPOAE is more sensitive than conventional pure tone audiometry, and in relation to TEOAE it is not only more sensitive but also more frequency‐specific. The follow‐up of patients could provide information both on early and late ototoxic events and also on individual sensitivity.…”

Effect of 1 Hz Repetitive Transcranial Magnetic Stimulation Over the Auditory Cortex on Audiometry and Otoacustic Emissions

“…These findings differ partially from our data, probably due to the type of otoacoustic emissions used for the assessment. Although transient-evoked otoacoustic emissions (TEOAEs) and DPOAEs provide similar information about cochlear mechanisms (Probst and Harris 1993;Gorga et al 1993), DPOAEs predict early manifestations of noise insults or future loss in hearing, even if hearing thresholds in the audiometry are not yet present and thus, DPOAEs appear to be a more sensitive method to detect cochlear damage (Seixas et al 2004;Al-Noury 2011). Hearing thresholds, measured by pure-tone audiometry as in our study, were not changed (Tringali et al 2011).…”

Audiological Monitoring in Children Treated with Platinum Chemotherapy

“…First of all, OAEs measure OHC activity and particularly distorsion products (DPOAEs) indicate frequency regions at which OHCs are mainly affected by platinum compounds. Secondly, OAE does not quantify hearing loss or hearing threshold level because normal OAE responses are not obtained if hearing thresholds are approximately 30-40 dB HL or higher, on the contrary they are more sensitive to detect cochlear damage than conventional pure-tone audiometry [Al Noury, 2011]. Third, distortion product OAEs are objective, rapid and noninvasive, reproducible and a stable test [Dhooge et al, 2006;Zimatore et al, 2011;Eiamprapai et al, 2012].…”