Distinguishing viruses responsible for influenza-like illness

Spencer, Jeanne P; Shutt, Deborah P.; Moser, S Kane; Clegg, Hannah; Wearing, Helen J.; Mukundan, Harshini; Manore, Carrie

doi:10.1016/j.jtbi.2022.111145

Cited by 24 publications

(22 citation statements)

References 117 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…HCoVs, specifically OC43, were the first viruses to reappear in wastewater after the omicron surge. HCoVs are highly transmissible with R 0 values higher, on average, than influenza and HRV, 28 but lower than RSV and similar to HPIV; there are no R 0 data for HMPV. 14 Infection with omicron also possibly reduced susceptibility to other respiratory viruses and contributed to the decrease in all viral activity; antibody cross immunity has been suggested to control temporal patterns of some respiratory viruses.…”

Section: Discussionmentioning

confidence: 97%

Wastewater concentrations of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus, rhinovirus, and seasonal coronavirus nucleic-acids during the COVID-19 pandemic: a surveillance study

Boehm¹,

Hughes²,

Duong³

et al. 2023

The Lancet Microbe

100

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 97%

Wastewater concentrations of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus, rhinovirus, and seasonal coronavirus nucleic-acids during the COVID-19 pandemic: a surveillance study

Boehm¹,

Hughes²,

Duong³

et al. 2023

The Lancet Microbe

100

View full text Add to dashboard Cite

“…Some limitations have to be considered when interpreting the results of the present study. Influenza-like illness can be caused by several pathogens, and thus the investigated association is obviously affected by the circulation of SARS-CoV-2, influenza, rhinoviruses and adenoviruses [ 15 ]. Our data indicated that for the particular period and setting, SARS-CoV-2 wastewater levels were a less important determinant of ILI rates in children than RSV and were only associated with ILI in the 15+ age group.…”

Section: Discussionmentioning

confidence: 99%

Wastewater Levels of Respiratory Syncytial Virus Associated with Influenza-like Illness Rates in Children—A Case Study in Larissa, Greece (October 2022–January 2023)

Koureas

Mellou

Vontas

et al. 2023

IJERPH

View full text Add to dashboard Cite

The emergence of the COVID-19 pandemic has led to significant progress in the field of wastewater-based surveillance (WBS) of respiratory pathogens and highlighted its potential for a wider application in public health surveillance. This study aimed to evaluate whether monitoring of respiratory syncytial virus (RSV) in wastewater can provide a comprehensive picture of disease transmission at the community level. The study was conducted in Larissa (Central Greece) between October 2022 and January 2023. Forty-six wastewater samples were collected from the inlet of the wastewater treatment plant of Larissa and analyzed with a real-time reverse transcription polymerase chain reaction (RT-PCR) based method. RSV and SARS-CoV-2 wastewater viral loads (genome copies/100,000 inhabitants) were analyzed against sentinel surveillance data on influenza-like illness (ILI) to identify potential associations. Univariate linear regression analysis revealed that RSV wastewater viral load (lagged by one week) and ILI notification rates in children up to 14 years old were strongly associated (std. Beta: 0.73 (95% CI: 0.31–1.14), p = 0.002, R2 = 0.308). A weaker association was found between SARS-CoV-2 viral load and ILI rates in the 15+ age group (std. Beta: 0.56 (95% CI: 0.06–1.05), p = 0.032, R2 = 0.527). The results support the incorporation of RSV monitoring into existing wastewater-based surveillance systems.

show abstract

“…HCoV, specifically OC43, was the first virus to re-appear in wastewater after the Omicon surge. Non-SARS-CoV-2 HCoV are highly transmissible with R0 values higher, on average, than influenza and rhinovirus 29 , but lower than RSV and similar to HPIV; there is limited R0 data for HMPV 15 . It is also possible that infection with Omicron reduced susceptibility to other respiratory viruses and contributed to the decrease in all viral activity; antibody cross immunity has been suggested to control temporal patterns of some respiratory viruses 5,30 .…”

Section: Discussionmentioning

confidence: 99%

Wastewater surveillance of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus (RSV), rhinovirus, and seasonal coronaviruses during the COVID-19 pandemic

Boehm

Hughes

Duong

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Respiratory disease is a major cause of morbidity and mortality; however, current surveillance for circulating respiratory viruses is passive and biased. Seasonal circulation of respiratory viruses changed dramatically during the COVID-19 pandemic. More active methods for understanding respiratory disease dynamics are needed to better inform public health response and to guide clinical decision making. Wastewater-based epidemiology has been used to understand COVID-19, influenza A, and RSV infection rates at a community level, but has not been used to investigate other respiratory viruses. Methods: We measured concentrations of influenza A and B, RSV A and B, human parainfluenza (1-4), rhinovirus, seasonal human coronaviruses, and human metapneumovirus RNA in wastewater solids three times per week for 17 months spanning the COVID-19 pandemic at a wastewater treatment plant in California, USA. Novel probe-based assays were developed and validated for non-influenza viral targets. We compared viral concentrations to positivity rates for viral infections from clinical specimens submitted to sentinel laboratories. Findings: We detected RNA from all target viruses in wastewater solids. Human rhinovirus and seasonal coronaviruses were found at highest concentrations. Concentrations of viruses correlated significantly and positively with positivity rates of associated viral diseases from sentinel laboratories. Measurements from wastewater indicated limited circulation of RSV A and influenza B, and human coronavirus OC43 dominated the seasonal human coronavirus infections while human parainfluenza 1 and 4A dominated among parainfluenza infections. Interpretation: Wastewater-based epidemiology can be used to obtain information on circulation of respiratory viruses at a community level without the need to test many individuals because a single sample of wastewater represents the entire contributing community. Results from wastewater can be available within 24 hours of sample collection, allowing real time information to inform public health response, clinical decision making, and individual behavior modifications.

show abstract

Distinguishing viruses responsible for influenza-like illness

Cited by 24 publications

References 117 publications

Wastewater concentrations of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus, rhinovirus, and seasonal coronavirus nucleic-acids during the COVID-19 pandemic: a surveillance study

Wastewater concentrations of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus, rhinovirus, and seasonal coronavirus nucleic-acids during the COVID-19 pandemic: a surveillance study

Wastewater Levels of Respiratory Syncytial Virus Associated with Influenza-like Illness Rates in Children—A Case Study in Larissa, Greece (October 2022–January 2023)

Wastewater surveillance of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus (RSV), rhinovirus, and seasonal coronaviruses during the COVID-19 pandemic

Contact Info

Product

Resources

About