Distinguishing monkeypox from its mimickers

Anogenital herpes simplex virus infection clinically indistinguishable from mpox (formerly named monkeypox)

“…11 In contrast to other STIs, almost all persons with MPXV-infection present with symptomatic disease. 3,4 We fully agree with Sprow et al 6 that clinicians should consider testing for HSV in addition to…”

“…[3][4][5] In contrast to all other sexually transmitted infections (STI), fluid-filled, umbilicated vesicules and pustules only occur in two conditions: mpox and herpes simplex virus (HSV) infection. In the Journal of Medical Virology, Sprow et al 6 recently provided a helpful guide for clinicians to distinguish mpox from other diseases with similar clinical findings, including HSV. We herein report two cases of unusual anogenital HSV infection that were clinically indistinguishable from mpox.…”