Distinguishing focal fibrotic lesions and non-fibrotic lesions in hypertrophic cardiomyopathy by assessment of regional myocardial strain using two-dimensional speckle tracking echocardiography: Comparison with multislice CT

Yajima, Rei; Kataoka, Akihisa; Takahashi, Atsuo; Uehara, Masae; Saito, Mariko; Yamaguchi, Chiharu; Lee, Kwang-Ho; Komuro, Issei; Funabashi, Nobusada

doi:10.1016/j.ijcard.2011.01.096

Cited by 36 publications

(20 citation statements)

References 56 publications

(73 reference statements)

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“…These studies suggested that speckle tracking, and measurements of GLPS, was able to identify an impaired LV function in more patients than LVEF. Also, in line with the findings in cardiology settings, where GLPS is regarded as a more sensitive measurement of systolic cardiac function than LVEF (45)(46)(47), changes in GLPS were seen earlier in the course of sepsis than changes in LVEF (48). Study II, in contrast,…”

Section: Echocardiographysupporting

confidence: 80%

“…In cardiology, speckle tracking echocardiography has been shown to be more sensitive in detecting cardiac diseases such as hypertrophic cardiomyopathy, cardiac amyloidosis and chemotherapy-associated cardiac dysfunction, even in asymptomatic patients (45)(46)(47). When the studies in this thesis were conducted, speckle tracking had scarcely been described in septic shock.…”

Section: Left Ventricular Diastolic Functionmentioning

confidence: 99%

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Cardiac dysfunction in septic shock : Observational studies on characteristics and outcome

Geer

2016

Linköping University Medical Dissertations

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Background: Cardiac dysfunction is a well-known complication of sepsis, but its characteristics and consequences, especially on a longer term, remain unclear. The aim of this thesis was to study the characteristics and the implications of cardiac dysfunction for outcome in intensive care unit (ICU) patients with septic shock. Purpose: First, to assess the ability of a cardiac biomarker to predict outcome in ICU patients. Second, to characterise cardiac dysfunction in septic shock using speckle tracking echocardiography. Third, to investigate the reliability of echocardiographic methods used to describe cardiac dysfunction in septic shock. Fourth, to study long-term cardiac outcome in severe sepsis and septic shock patients. Materials and methods: The cardiac biomarker amino-terminal pro-brain natriuretic peptide (NTproBNP) was collected in 481 patients on ICU admission and its ability to predict death was assessed. In 50 patients with septic shock, echocardiography was performed on ICU admission and was repeated during and after ICU stay. Measurements of cardiac strain using speckle tracking echocardiography were assessed in relation to other echocardiographic function parameters, NT-proBNP and severity of illness scores, and their change over time was analysed. Echocardiograms from patients with septic shock were independently evaluated by two physicians and the results analysed regarding measurement variability. A nationwide-registry-based open cohort of 9,520 severe sepsis and septic shock ICU patients discharged alive from the ICU was analysed together with a non-septic control group matched for age, sex and severity of illness. In patients who died after ICU discharge, information on causes of death was collected. Results: A discriminatory level of significance of NT-proBNP on ICU admission was identified at ≥1,380 ng/L, above which NT-proBNP was an independent predictor of death. With increasing levels of NT-proBNP, patients were more severely ill, had a longer ICU stay and were more often admitted with septic shock. Cardiac strain was frequently impaired in septic shock patients but was not superior to other echocardiographic measurements in detecting cardiac dysfunction. Cardiac strain correlated with other echocardiographic function parameters and with NT-proBNP, and was the least user-dependent echocardiographic parameter in septic shock patients. Cardiac strain remained unchanged over time, did not differ between survivors and non-survivors and could not predict an increased risk of death. During a follow-up of up to nearly 6 years after ICU discharge, 3,954 (42%) of sepsis patients died, 654 (17%) with cardiac failure as the cause of death. With increasing severity of illness on admission, the risk of death with cardiac failure as the cause of death after ICU discharge increased. In comparison to other ICU patients with similar severity of illness, however, the risk of death due to cardiac was not increased in patients with severe sepsis or septic shock. Conclusions: Laboratory or echocardiographic si...

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Section: Echocardiographysupporting

confidence: 80%

Section: Left Ventricular Diastolic Functionmentioning

confidence: 99%

Cardiac dysfunction in septic shock : Observational studies on characteristics and outcome

Geer

2016

Linköping University Medical Dissertations

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“…LeMDCT was introduced for the demonstration of LE in selected [12][13][14][15][16] and consecutive patients with HCM [17]. LE in HCM was proven to be of prognostic relevance [18].…”

Section: Discussionmentioning

confidence: 99%

“…The addition of LE to further prognostically relevant volumetric parameters describing LV function and dimensions has been shown to increase knowledge regarding a patient's health, cardiac status, and prognosis [24]. This is the first analysis showing low-contrast leMDCT indicated for the visualization of LE, marking (intra)myocardial fibrosis in HCM [12][13][14][15][16][17][18] or post-ischemic scars in CAD [7][8][9][10][11], to allow for accurate LV volumetry ( Table 2). As known from full-contrast MDCT datasets (acquired during first pass) [23,25], LV-MM can be assessed in close analogy to the current gold standard method -regardless of whether it is performed semiautomatically or manually (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…In consideration of the prognostic role of fibrosis, and in light of the growing body of validated leMDCT data for LE in HCM [12][13][14][15][16][17][18], leMDCT may gain increasing importance with regard to imaging of fibrosis in the context of cardiovascular risk assessment in affected patients. However, pure detection and quantification of LE may not be as relevant.…”

Section: Introductionmentioning

confidence: 99%

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Late enhanced computed tomography in Hypertrophic Cardiomyopathy enables accurate left-ventricular volumetry

et al. 2014

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Advanced echocardiographic techniques

Perry

Joseph

2012

Australas J Ultrason Med

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Echocardiography has advanced significantly since its first clinical use. The move towards more accurate imaging and quantification has driven this advancement. In this review, we will briefly focus on three distinct but important recent advances, three‐dimensional (3D) echocardiography, contrast echocardiography and myocardial tissue imaging. The basic principles of these techniques will be discussed as well as current and future clinical applications.

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Distinguishing focal fibrotic lesions and non-fibrotic lesions in hypertrophic cardiomyopathy by assessment of regional myocardial strain using two-dimensional speckle tracking echocardiography: Comparison with multislice CT

Cited by 36 publications

References 56 publications

Cardiac dysfunction in septic shock : Observational studies on characteristics and outcome

Cardiac dysfunction in septic shock : Observational studies on characteristics and outcome

Late enhanced computed tomography in Hypertrophic Cardiomyopathy enables accurate left-ventricular volumetry

Advanced echocardiographic techniques

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