Distinguishing between Vascular Dementia and Alzheimer's Disease by Means of the WAIS: A Meta-analysis

Oosterman, Joukje M.; Scherder, E.J.A.

doi:10.1080/13803390500263543

Cited by 15 publications

(8 citation statements)

References 91 publications

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“…Though AD and VaD cases show impairment in memory, recall memory in AD is typically worse than in VaD (Oosterman & Scherder, 2006). The current results suggested that the memory faculties of VaD patients are more intact than AD patients, a finding which corroborates previous research (Boyle et al, 2004;Golden et al, 2005).…”

Section: Discussionsupporting

confidence: 88%

Distinguishing Alzheimer's Disease From Vascular Dementia: An Exploration of Five Cognitive Domains

Heyanka

Mackelprang

Golden

et al. 2010

International Journal of Neuroscience

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The disease process of Alzheimer's disease (AD) and Vascular Dementia (VaD) are dissimilar; however, the cognitive presentations may be difficult to distinguish as they may present in tandem or result in similar deficits despite different pathogenesis. This study examined the efficacy of memory, confrontational naming, visuoconstructional ability, processing speed, and executive functioning in differentiating AD from VaD. Delayed verbal memory, visuoconstructional ability, and confrontational naming as measured by WMS-R Logical Memory II, WAIS-R Block Design (BD), and Boston Naming Test, respectively, were most effective in discriminating between these two disorders. Results indicated AD was best classified by BD, and BD was the most sensitive to AD-related pathogenesis. Delayed memory and confrontational naming were highly implicated in each subtype, suggesting they are sensitive to each disease process, thus reducing the reliability of utilizing them as sole differentiating agents.

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Section: Discussionsupporting

confidence: 88%

Distinguishing Alzheimer's Disease From Vascular Dementia: An Exploration of Five Cognitive Domains

Heyanka

Mackelprang

Golden

et al. 2010

International Journal of Neuroscience

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“…The value of relationship-centred care in dementia has already been highlighted. Care capturing the interdependencies within caring relationships has been highlighted (Nolan, Ryan, Enderby, & Reid, 2002). However, this research makes explicit the need to consider individuals’ relationships with carers and staff, but also relationships between individuals with dementia themselves and the dynamics associated with these interactions.…”

Section: Discussionmentioning

confidence: 99%

The subjective experience of personhood in dementia care settings

Nowell¹,

Thornton

Simpson

2011

Dementia

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Within the social psychological understanding of dementia, individuals' personhood is central. A respect for personhood has been linked to successful person-centred care, yet research exploring subjective personhood in dementia is scarce. This study aimed to understand personhood by exploring the subjective experiences of those with dementia. Seven individuals with dementia were interviewed and interpretative phenomenological analysis was used to identify themes across accounts. Themes identified were: (1) working out the system and adapting in order to survive it--the 'peoplehood' of the system; (2) using past and future roles and experiences to manage the present--the transient nature of personhood; (3) being both an individual and a member of a group--the conflict of a dual role. The themes highlighted showed that individuals with dementia supported their personhood by drawing on their own, others' and the system's resources. The findings are discussed and links with existing literature and clinical implications are considered.

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“…Vascular dementia and Alzheimer's disease have a considerable degree of overlap in terms of neuropsychological impairments, although there is a tendency for vascular dementia to be associated with greater deficits in attention, speed of information processing, and executive function, 48 whereas subjects with Alzheimer's disease have more problems with semantic memory 49,50 . Thus, it was of interest to evaluate whether plasma lipoproteins potentially linked to vascular disease influenced specific domains of cognitive impairment.…”

Section: Discussionmentioning

confidence: 99%

“…49,50 Thus, it was of interest to evaluate whether plasma lipoproteins potentially linked to vascular disease influenced specific domains of cognitive impairment. It was found that associations between lipoprotein levels and cognitive function tests were of borderline significance or not significant at baseline and during follow-up.…”

Section: Discussionmentioning

confidence: 99%

Association Between Apolipoprotein E₄ and Cognitive Decline in Elderly Adults

Packard

Westendorp

Stott

et al. 2007

J American Geriatrics Society

114

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OBJECTIVE:To determine the influence of apolipoprotein E on cognitive decline in a cohort of elderly men and women. DESIGN: Prospective study. SETTING: Scotland, Ireland, and the Netherlands. PARTICIPANTS: Five thousand eight hundred four subjects aged 70 to 82 from the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER). MEASUREMENTS: Subjects were assessed at baseline and over a mean 3.2-year (range 0.7-4.2) follow-up for memory (Picture-Word Recall), speed of information processing (Stroop and Letter-Digit Coding), global cognitive function (Mini-Mental State Examination), and activities of daily living. RESULTS: At baseline, subjects with apolipoprotein E 4 versus those without E 4 had poorer memory performance (mean score difference À 0.20 (95% confidence interval (CI) 5 À 0.31 to À 0.09) for immediate recall and À 0.32 (95% CI 5 À 0.48 to À 0.16) for delayed recall and slower information processing (difference in Stroop, 2.79 seconds, (95% CI 5 1.20-4.28); Letter-Digit score, À 0.36, (95% CI 5 À 0.77-0.05). Subjects with apolipoprotein E 4 showed a greater decline in immediate ( À 0.22, 95% CI 5 À 0.33 to À 0.11) and delayed ( À 0.30, 95% CI 5 À 0.46 to À 0.15) memory scores but no significant change in speed of information processing (Stroop, P 5.17; Letter-Digit, P 5.06). Memory scores decreased 2.5% from baseline in those without E 4 , 4.3% in E 4 heterozygotes (P 5.01 for immediate and P 5.03 for delayed, vs no E 4 ) and 8.9% to 13.8% in E 4 homozygotes (P 5.04 for immediate and P 5.004 for delayed, vs heterozygotes). Apolipoprotein E 4 was associated with greater decline in instrumental activities of daily living (Po.001). Cognitive decline was not associated with lipoprotein levels. CONCLUSION: Findings in PROSPER indicate that E 4 is associated with more-rapid cognitive decline and may, therefore, predispose to dementia. J Am Geriatr Soc 55:1777-1785, 2007. Key words: memory; dementia; trial; statin A major challenge in the quest to promote healthy aging is to uncover the determinants of cognitive decline in the general population and the risk factors that lead to the development of frank dementia. Although age is the main predictor of cognitive function, investigators have also reported that a history of hypertension, diabetes mellitus, stroke, depression, and lack of physical activity are factors. [1][2][3][4][5][6] The apolipoprotein E phenotype (apolipoprotein E is coded by a gene (e) that exhibits allelic variants e 2 , e 3 , and e 4 ) has been linked consistently and strongly to the appearance of Alzheimer's disease and to some aspects of cognitive decline in elderly cohorts. 1,2,[5][6][7][8][9] Inheritance of E 4 (the product of e 4 ) especially in the homozygous form, has been associated in cross-sectional studies with risk of Alzheimer's disease and poorer global cognitive function, episodic memory, and executive function, although the magnitude of the effect is modest. 10,11 Longitudinal data also show good evidence of an association between E 4 and risk of Alzheimer's diseas...

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Distinguishing between Vascular Dementia and Alzheimer's Disease by Means of the WAIS: A Meta-analysis

Abstract: This study was intended to, meta-analytically, review

Cited by 15 publications

References 91 publications

Distinguishing Alzheimer's Disease From Vascular Dementia: An Exploration of Five Cognitive Domains

Distinguishing Alzheimer's Disease From Vascular Dementia: An Exploration of Five Cognitive Domains

The subjective experience of personhood in dementia care settings

Association Between Apolipoprotein E₄ and Cognitive Decline in Elderly Adults

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Distinguishing between Vascular Dementia and Alzheimer's Disease by Means of the WAIS: A Meta-analysis

Abstract: This study was intended to, meta-analytically, review

Cited by 15 publications

References 91 publications

Distinguishing Alzheimer's Disease From Vascular Dementia: An Exploration of Five Cognitive Domains

Distinguishing Alzheimer's Disease From Vascular Dementia: An Exploration of Five Cognitive Domains

The subjective experience of personhood in dementia care settings

Association Between Apolipoprotein E4 and Cognitive Decline in Elderly Adults

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Association Between Apolipoprotein E₄ and Cognitive Decline in Elderly Adults