Distinguishing between adverse and non-adverse effects – Session summarySession Report from the Joint STP/IFSTP International Symposium “Toxicologic Pathology in the New Millenium” June 24–28, 2001, in Orlando, Florida

Karbe, E.; Williams, Gary M.; Lewis, Robert C.; Kimber, Ian; Foster, Preston

doi:10.1016/s0940-2993(04)70074-3

Cited by 2 publications

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“…However, these changes were not regarded to be adverse effects because they were not dose-dependent nor accompanied by an increase in the absolute organ weight of livers, or alterations of serum chemical markers of liver injury, and not associated with histopathological alterations in the liver ( 8 ). Furthermore, if liver weight caused by hypertrophy and hyperplasia does not involve an increase up to 20%, and is not accompanied by histopathological changes, it is not considered as an adverse effect in rodents ( 10 ). Finally, the increase of liver organ weight can be regarded as an adverse effect only if accompanied by alterations in parameter of hepatobiliary damage or dysfunction ( 11 , 12 ).…”

Section: Discussionmentioning

confidence: 99%

Subacute Inhalation Toxicity of 3-Methylpentane

et al. 2016

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3-Methylpentane (C6H14, CAS No. 96-14-0), isomer of hexane, is a colorless liquid originating naturally from petroleum or natural gas liquids. 3-Methylpentane has been used as a solvent in organic synthesis, as a lubricant, and as a raw material for producing carbon black. There is limited information available on the inhalation toxicity of 3-methylpentane, and the aim of this study was to determine its subacute inhalation toxicity. According to OECD Test Guideline 412 (subacute inhalation toxicity: 28-day study), Sprague Dawley rats were exposed to 0, 284, 1,135, and 4,540 ppm of 3-methylpentane for 6 hr/day, 5 days/week for 4 weeks via whole-body inhalation. Mortality, clinical signs, body weights, food consumption, hematology, serum chemistry, organ weights, and gross and histopathological findings were compared between control and all exposure groups. No mortality or remarkable clinical signs were observed during the study. No gross or histopathological lesions, or adverse effects on body weight, food consumption, hematology, serum chemistry, and organ weights were observed in any male or female rats in all exposure groups, although some statistically significant changes were observed in food consumption, serum chemistry, and organ weights. In conclusion, the results of this study indicate that no observable adverse effect level (NOAEL) for 3-methylpentane above 4,540 ppm/6 hr/day, 5 days/week for rats.

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