Distinguish the toxic differentiations between acute exposure of micro- and nano-plastics on bivalves: An integrated study based on transcriptomic sequencing

Qi, Pengzhi; Qiu, Longmei; Feng, Dan; Gu, Zemao; Guo, Baoying

doi:10.1016/j.aquatox.2022.106367

Cited by 16 publications

(3 citation statements)

References 92 publications

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“…The expression patterns and clustering of these genes may reflect their functional roles and pathways, modulated by different nanoplastics. 63 The nanoplastics have distinct physicochemical characteristics that affect their interactions with the cellular components. For example, PS-NP and PP-NP are more hydrophobic and positively charged than PE-NP, which may influence their uptake, distribution, and accumulation in the cells.…”

Section: Discussionmentioning

confidence: 99%

Comparative toxicity of polystyrene, polypropylene, and polyethylene nanoplastics on Artemia franciscana nauplii: a multidimensional assessment

Sultan,

Wei,

Duan

et al. 2024

Environ. Sci.: Nano

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Section: Discussionmentioning

confidence: 99%

Comparative toxicity of polystyrene, polypropylene, and polyethylene nanoplastics on Artemia franciscana nauplii: a multidimensional assessment

Sultan,

Wei,

Duan

et al. 2024

Environ. Sci.: Nano

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“…Transcriptome analysis is widely used in the study of molecular level in biology along with the development of sequencing technologies. In recent years, transcriptome analysis has gradually been applied in the toxicology research of NPs on aquatic organisms, such as B. plicatilis , D. pulex , Isognomon alatus , Mytilus coruscus , Cherax quadricarinatus , C. robusta , D. rerio , Oreochromis mossambicus , I. punetaus ( Liu et al, 2021a ; Pang et al, 2021 ; Arini et al, 2022 ; Yu et al, 2022b ; Cheng et al, 2022 ; Jiang et al, 2022 ; Shin and Jeong, 2022 ; Eliso et al, 2023 ; Qi et al, 2023 ). To research the effect of NPs on the molecular level of S. esculenta larvae, we applied RNA-Seq technology in this research.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic analysis of oxidative stress mechanisms induced by acute nanoplastic exposure in Sepia esculenta larvae

Liu

Yang

2023

Front. Physiol.

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Nanoplastics (NPs), as a new type of pollutant with a size small than 1 μm, are ubiquitous and harmful to organisms. There has been an increasing amount of research concerning the effects of NPs on organisms over recent years, especially on aquatic animals. However, there is a limited study on the impact of NPs on mollusk cephalopods. In this research, Sepia esculenta, belonging to Cephalopoda, Coleoidea, Sepioidea, was selected to explore the effects caused by NPs exposure. The S. esculenta larvae were exposed to polystyrene NPs (PS-NPs) with diameter 50 nm (100 mg/L) for 4 h. The detection of oxidative stress biomarkers displayed an obvious increase in SOD (superoxide dismutase) activity and MDA (malondialdehyde) level. Then, RNA-Seq was performed to explore the oxidative stress response at mRNA level. The transcriptome analysis demonstrated that the expression of 2,570 genes was affected by PS-NPs. Besides, the signaling pathways of ribosome, ribosome biogenesis in eukaryotes, proteasome, and MAPK were enriched. This study not only provides novel references for understanding the mechanisms of oxidative stress response induced by NPs, but also reminds us to follow with interest the influence of acute exposure to NPs.

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“…Nanoplastics with smaller sizes, stronger surface reactivity, and higher mobility could result in higher environmental risk than microplastics . For example, nanoplastics exhibited a higher toxicity to aquatic organisms (such as algae, zooplankton, fish, and bivalves) than microplastics. However, nanoplastics have not attracted as much attention as microplastics, and a better understanding of their ecotoxicological risks is certainly warranted …”

mentioning

confidence: 99%

Mechanistic Understanding toward the Maternal Transfer of Nanoplastics in Daphnia magna

Xue

Lan

et al. 2023

ACS Nano

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Nanoplastics induce transgenerational toxicity to aquatic organisms, but the specific pathways for the maternal transfer of nanoplastics remain unclear. Herein, laser scanning confocal microscopy (LSCM) observations identified the specific pathways on the maternal transfer of polystyrene (PS) nanoplastics (25 nm) in Daphnia magna. In vivo and in vitro experiments showed that PS nanoplastics could enter the brood chamber through its opening and then be internalized to eggs and embryos using LSCM imaging (pathway I). In addition, PS nanoplastics were observed in the oocytes of the ovary, demonstrating gut–ovary–oocyte transfer (pathway II). Furthermore, label-free hyperspectral imaging was used to detect the distribution of nanoplastics in the embryos and ovary of Daphnia, again confirming the maternal transfer of nanoplastics through the two pathways mentioned above. The contribution from pathway I (88%) was much higher than pathway II (12%) based on nanoflow cytometry quantification. In addition, maternal transfer in Daphnia depended on the particle size of PS nanoplastics, as demonstrated by using LSCM and hyperspectral imaging. Unlike 25 nm nanoplastics, 50 nm PS nanoplastics could enter the brood chamber and the eggs/embryos (pathway I), but were not detected in the ovary (pathway II); 100 nm PS nanoplastics were difficult to be internalized by eggs/embryos and could not enter the ovary either. These findings provide insight into the maternal transfer mechanisms of nanoplastics in Daphnia, and are critical for better understanding the transgenerational toxicity of aquatic organisms.

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Distinguish the toxic differentiations between acute exposure of micro- and nano-plastics on bivalves: An integrated study based on transcriptomic sequencing

Cited by 16 publications

References 92 publications

Comparative toxicity of polystyrene, polypropylene, and polyethylene nanoplastics on Artemia franciscana nauplii: a multidimensional assessment

Comparative toxicity of polystyrene, polypropylene, and polyethylene nanoplastics on Artemia franciscana nauplii: a multidimensional assessment

Transcriptomic analysis of oxidative stress mechanisms induced by acute nanoplastic exposure in Sepia esculenta larvae

Mechanistic Understanding toward the Maternal Transfer of Nanoplastics in Daphnia magna

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