Abstract:Hsp60 is a Group I chaperonin highly conserved during evolution that in normal human cells is localized mainly in the mitochondrial matrix but stress causes changes in its levels and localization. We studied with a battery of techniques human mucosa from: a) normal colon (NM); b) hyperplastic polyps (HP); c) tubular adenomas with dysplasia (TAD); d) Crohn's disease (CD); e) ulcerative colitis (UC); and f) adenocarcinomas (AC). We observed patterns of Hsp60 levels and subcellular localization which depended on … Show more
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