Distinctive Mechanisms and Patterns of Exudative Versus Tractional Intraretinal Cystoid Spaces as Seen With Multimodal Imaging

Govetto, Andrea; Sarraf, David; Hubschman, Jean‐Pierre; Tadayoni, Ramin; Couturier, Aude; Chehaibou, Ismaël; Au, Adrian; Grondin, Christelle; Virgili, Gianni; Romano, Mario R.

doi:10.1016/j.ajo.2019.12.010

Cited by 40 publications

(55 citation statements)

References 35 publications

(57 reference statements)

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“… 15 , 16 This coincidence of cystic patterns seems to be linked to Müller cells radial distribution in the parafovea where they present a Z-shaped course, spanning through the HFL in an almost horizontal orientation. In fact, a recent study by Govetto et al 17 analyzed intraretinal cystoid spaces characteristics in tractional macular edema and described a spoke-wheel pattern of the cysts observed in the en face SD-OCT of different tractional macular disorders which is consistent with the one presented in this case ( Fig. 3 ).…”

Section: Discussionsupporting

confidence: 89%

Stellate nonhereditary idiopathic foveomacular retinoschisis resolution after vitreomacular adhesion release

Nogueira

Costa

Isenberg

et al. 2021

American Journal of Ophthalmology Case Reports

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Structured Abstract Purpose To present a case of stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) resolution associated with vitreomacular adherence (VMA) release and propose a potential contributing association between SNIFR and vitreomacular interactions. Observations A 67-year-old female patient was diagnosed and followed for SNIFR in OD with spectral-domain optical coherence tomography (SD-OCT) scans at presentation and subsequent visits at 3, 6, 16 and 22 months. VMA and foveomacular retinoschisis remained unchanged on SD-OCT during the first 6 months of the follow-up. At 16-month follow-up visit, SD-OCT revealed VMA release and an important improvement of the macular schisis. At 22 months of follow-up, SNIFR cavities completely resolved in the presence of posterior hyaloid separation from the macular area without any adjunct treatment. The authors could not identify any other possible cause to justify the resolution of SNIFR other than VMA release in this case. Patient did not undergo any treatment for OD other than phacoemulsification 3 months after initial visit. Conclusion The present case illustrates with SD-OCT scans a possible association between SNIFR resolution and VMA release, highlighting a potential tractional component of the posterior vitreous on the internal limiting membrane and consequent glial cells stretching with schisis formation.

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Section: Discussionsupporting

confidence: 89%

Stellate nonhereditary idiopathic foveomacular retinoschisis resolution after vitreomacular adhesion release

Nogueira

Costa

Isenberg

et al. 2021

American Journal of Ophthalmology Case Reports

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“…Many of the pathologies requiring vitreoretinal (VR) surgery are accompanied by pro-inflammatory responses, which may result in vascular CME [147]. Retinal surgery itself may further enhance such inflammatory reactions, which may worsen or facilitate the onset of CME [148]. The use of Ozurdex as adjuvant to PPV may be useful, due to its long-lasting biological activity.…”

Section: Evidence Of the Efficacy Of Dex In Vitreoretinal Surgerymentioning

confidence: 99%

“…Kim et al, found the use of Ozurdex as adjuvant to PPV particularly effective in case of tractional CME if compared to the vascular subtype [152]. In such cases, the net benefit of Ozurdex is controversial, as the action of PPV alone may be sufficient to resolve tractional CME [148]. However, a purely tractional aetiology is rare in DME and often tractional and exudative components may overlap [148].…”

Section: Evidence Of the Efficacy Of Dex In Vitreoretinal Surgerymentioning

confidence: 99%

“…In such cases, the net benefit of Ozurdex is controversial, as the action of PPV alone may be sufficient to resolve tractional CME [148]. However, a purely tractional aetiology is rare in DME and often tractional and exudative components may overlap [148].…”

Section: Evidence Of the Efficacy Of Dex In Vitreoretinal Surgerymentioning

confidence: 99%

“…ERMs may be associated with CME, whose origin can be either tractional, exudative, or a combination of both [148]. In such contexts, the anti-inflammatory action of Ozurdex may be synergic with the mechanical release of tractional forces achieved with PPV.…”

Section: Evidence Of the Efficacy Of Dex In Vitreoretinal Surgerymentioning

confidence: 99%

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Intravitreal Dexamethasone Implant as a Sustained Release Drug Delivery Device for the Treatment of Ocular Diseases: A Comprehensive Review of the Literature

et al. 2020

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Drug delivery into the vitreous chamber remains a great challenge in the pharmaceutical industry due to the complex anatomy and physiology of the eye. Intravitreal injection is the mainstream route of drug administration to the posterior segment of the eye. The purpose of this review is to assess the current literature about the widening use of the intravitreal 0.7 mg dexamethasone (Dex) implant, and to provide a comprehensive collection of all the ocular disorders that benefit from Dex administration. Although anti-vascular endothelial growth-factors (VEGFs) have been largely indicated as a first-choice level, the Dex implant represents an important treatment option, especially in selected cases, such as vitrectomized eyes or patients in whom anti-VEGF failed or are contraindicated. In this article, the safety profile as well as the list of the possible complications related to intravitreal Dex injection are also discussed.

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Macular capillary displacement in exudative and tractional macular oedema: a multimodal imaging study and pathophysiological hypothesis

Govetto

Mazzotta

Al-Sheikh

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Distinctive Mechanisms and Patterns of Exudative Versus Tractional Intraretinal Cystoid Spaces as Seen With Multimodal Imaging

Cited by 40 publications

References 35 publications

Stellate nonhereditary idiopathic foveomacular retinoschisis resolution after vitreomacular adhesion release

Stellate nonhereditary idiopathic foveomacular retinoschisis resolution after vitreomacular adhesion release

Intravitreal Dexamethasone Implant as a Sustained Release Drug Delivery Device for the Treatment of Ocular Diseases: A Comprehensive Review of the Literature

Macular capillary displacement in exudative and tractional macular oedema: a multimodal imaging study and pathophysiological hypothesis

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