Distinctive hippocampal CA2 subfield of the Amazon rodent Proechimys

Scorza, Carla A.; Araújo, Bruno Henrique Silva; Arida, Ricardo Mário; Scorza, Fúlvio A.; Torres, Laila Brito; Amorim, Henrique Alves de; Cavalheiro, Ésper A.

doi:10.1016/j.neuroscience.2010.05.079

Cited by 14 publications

(8 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some species of rodent may even be seizure-resistant due to unique CA2 cytoarchitecture [123]. Cell loss in CA2 is decorrelated from DG cell loss in medial temporal lobe epilepsy [124], consistent with CA2's unique connectivity within hippocampal circuits allowing decoupling from the DG-CA3-CA1 loop.…”

Section: Box 4: Ca2 In Diseasementioning

confidence: 90%

Updating hippocampal representations: CA2 joins the circuit

Jones

McHugh

2011

Trends in Neurosciences

111

106

View full text Add to dashboard Cite

The hippocampus integrates the encoding, storage and recall of memories, binding the spatiotemporal and sensory information that constitutes experience and keeping episodes in their correct context. The rapid and accurate processing of such daunting volumes of continuouslychanging data relies on dynamically assigning different aspects of mnemonic processing to specialized, interconnected networks corresponding to the anatomical subfields of dentate gyrus (DG), CA3 and CA1. However, differentially processed information ultimately has to be reintegrated into conjunctive representations, and this is unlikely to be achieved by unidirectional, sequential steps through a DG-CA3-CA1 loop. In this Review, we highlight recently discovered anatomical and physiological features that are likely to necessitate updates to the hippocampal circuit diagram, particularly by incorporating the oft-neglected CA2 region.3

show abstract

Section: Box 4: Ca2 In Diseasementioning

confidence: 90%

Updating hippocampal representations: CA2 joins the circuit

Jones

McHugh

2011

Trends in Neurosciences

111

106

View full text Add to dashboard Cite

show abstract

“…Interestingly, Proechimys guyannensis , a rodent native to the Amazon region, shows distinctly dispersed neurons in the CA2 SP and increased resistance to experimental epileptogenesis compared with Wistar rats 119 . In addition, compared with Wistar rats, P. guyannensis shows high basal expression of calbindin 1 and calbindin 2 (also known as calretinin) within the CA2 region, which are likely to be expressed in interneurons 120 .…”

Section: Resistance To Injurymentioning

confidence: 98%

Rediscovering area CA2: unique properties and functions

2016

View full text Add to dashboard Cite

Hippocampal area CA2 has several features that distinguish it from CA1 and CA3, including a unique gene expression profile, failure to display long-term potentiation and relative resistance to cell death. A recent increase in interest in the CA2 region, combined with the development of new methods to define and manipulate its neurons, has led to some exciting new discoveries on the properties of CA2 neurons and their role in behaviour. Here, we review these findings and call attention to the idea that the definition of area CA2 ought to be revised in light of gene expression data.

show abstract

“…The quantification of the sections immunostained with DAB was performed with a computational system developed in MATLAB (Scorza et al, 2010) for optical densitometry analysis. Two regions were analyzed: the pyramidal layer of CA1 and the granular layer of the infra-pyramidal blade (IP) of the DG.…”

Section: Optical Densitometrymentioning

confidence: 99%