Distinctive cytoplasmic inclusions in chronic lymphocytic leukaemia

Leukaemic reticuloendotheliosis: A morphological and immunological study of four cases

“…Thus, their lack of positivity in the Sudan black and peroxidase reactions resembled that of lymphocytes, but their PAS and acid phosphatase reactivity was more typical of monocytes (Hayhoe and Flemans, 1969). However, the recent finding of intracytoplasmic inclusions in some cases of leukaemic reticuloendotheliosis (Katayama et al, 1972;Daniel and Flandrin, 1974;Catovsky et al, 1974a)-a finding we have confirmed in this studysuggests a relationship to chronic lymphocytic leukaemia in which similar inclusions may be observed (Zucker-Franklin, 1963;Anday, Goodman, and Tishkoff, 1974;Cawley, Emmines, Goldstone, Hamblin, Hough, and Smith, 1974). The response in vitro to PHA of leucocyte preparations from patients with leukaemic reticuloendotheliosis has been examined by several workers (Trubowitz et al, 1971;Yam et al, 1968, Catovsky et al, 1974b and in most cases a poor response has been obtained.…”

Ribosome lamella complex in neoplastic cells of a Sézary's syndrome.

“…Furthermore, these inclusions have been regarded as an ultrastructural marker of this disease (Katayama et al, 1972;Daniel and Flandrin, 1974). However, although infrequently, such inclusions were reported in the lymphocytes from six patients with chronic lymphocytic leukaemia (Zucker-Franklin, 1963;Brunning and Parkin, 1975;Cawley et al, 1975;Woessner and Rozman, 1976;Katayama and Schneider, 1977), three patients with lymphosarcoma cell leukaemia (Anday et al, 1973;Djaldetti et al, 1974;Katayama and Schneider 1977), one patient with Waldenstrom's macroglobulinaemia (Brunning and Parkin, 1975), and one patient with follicular malignant lymphoma (Reynes and Diebold, 1977), all diseases known to be of B cell nature (Siegal et al, 1978). They were also described in non lympho-proliferative disorders, such as two cases of acute monocytic leukaemia (Brunning and Parkin, 1975) as well as non haematopoietic diseases, such as an adrenal cortical adenoma from a patient with Cushing's syndrome (Hoshino, 1969) and in cells from other mammals and plants (Bartels and Weier, 1967;Bulger, 1968).…”

Auer Rod-Like Inclusions in Prolymphocytic Leukemia

“…A variety of intracytoplasmic inclusions in lym phoid cells from patients with lymphoproliférative disorders has been reported [1,[10][11][12][13][14][15]. On ultrastruc tural examination these cytoplasmic inclusions are crystalline, globular, tubular or lamellar in appear ance.…”