Distinctive Aspects of Laboratory Testing to Evaluate Mineral and Bone Metabolism in Patients with Chronic Kidney Disease

Souberbielle, Jean‐Claude; Cheriet, Sarah; Cavalier, Étienne

doi:10.1016/s1297-319x(12)70016-7

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…These results differ from those found among community-dwellers in whom the VDSP was effective in identifying mainly vitamin D insufficiency [ 8 ]. This difference can be explained by obvious health differences between general population and patients [ 17 ], and justifies distinguishing between these two populations while assessing the risk of hypovitaminosis D.…”

Section: Discussionmentioning

confidence: 99%

Clinical Identification of Geriatric Patients with Hypovitaminosis D: The ‘Vitamin D Status Predictor for Geriatrics’ Study

et al. 2017

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The 16-item Vitamin D Status Predictor (VDSP) tool identifies healthy older community-dwellers at risk of hypovitaminosis D and may guide the use of blood tests in this population. The objective of the present hospital-based study was to test the efficacy of the VDSP to identify geriatric patients with hypovitaminosis D. The study included 199 nonsupplemented geriatric in- and outpatients consecutively admitted to Angers University Hospital, France (mean ± SD, 82.0 ± 7.8 years; 53.3% female). Serum 25-hydroxyvitaminD (25(OH)D) was measured at the time of the physician-administered VDSP. Hypovitaminosis D was defined as serum 25(OH)D concentration ≤ 75 nmol/L for vitamin D insufficiency, 25(OH)D ≤ 50 nmol/L for vitamin D deficiency, and 25(OH)D ≤ 25 nmol/L for severe vitamin D deficiency. We found that 184 participants (92.4%) had vitamin D insufficiency, 136 (68.3%) had vitamin D deficiency, and 67 (33.7%) had severe vitamin D deficiency. The VDSP identified severe vitamin D deficiency with an area under curve (AUC) = 0.83 and OR = 24.0. The VDSP was able to identify vitamin D deficiency and vitamin D insufficiency with less accuracy (AUC = 0.71 and AUC = 0.73, respectively). In conclusion, the 16-item VDSP is a short questionnaire that accurately identifies geriatric patients with severe vitamin D deficiency. This tool may guide the use of blood collection for determining geriatric patients’ vitamin D status.

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Section: Discussionmentioning

confidence: 99%

Clinical Identification of Geriatric Patients with Hypovitaminosis D: The ‘Vitamin D Status Predictor for Geriatrics’ Study

et al. 2017

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Treatment secondary hyperparathyroidoidism in a patient receiving hemodialysis with combination therapy – paricalcitol and cinacalcet

Egshatyan

2020

Nefrologiâ (St.-Peterbg.)

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The article is devoted to the problem of treatment of secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD) on renal replacement therapy with programmed hemodialysis. The pathogenesis of VHPT is based on vitamin D deficiency and the associated launch of a cascade of complications of mineral metabolism, which subsequently leads to significant changes in the morphology and density of bone tissue, as well as cardiovascular complications. According to the main clinical guidelines, the goals of treating IHPT in patients with CKD are aimed at preventing the progression of the disease and suppressing the activity of the parathyroid glands by modulating vitamin D receptors and calcium-sensitive receptors. Maintaining the level of parathyroid hormone within the target values improves the quality of life of patients, reduces the incidence of cardiovascular and bone complications. The article presents the result of our own clinical observation on the correction of alfacalcidol-resistant IHPT with hypercalcemia and hyperphosphatemia in a patient on programmed hemodialysis using a combination therapy with a calcimimetic – cinacalcet, colecalciferol and a selective activator of vitamin D receptors – paricalcitol. On the example of a clinical case, the compensation of IHPT, an improvement in the condition of the altered parathyroid glands, bone tissue without the risk of developing hypo-, hypercalcemia and hyperphosphatemia during long-term treatment was demonstrated.

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Distinctive Aspects of Laboratory Testing to Evaluate Mineral and Bone Metabolism in Patients with Chronic Kidney Disease

Cited by 2 publications

References 16 publications

Clinical Identification of Geriatric Patients with Hypovitaminosis D: The ‘Vitamin D Status Predictor for Geriatrics’ Study

Clinical Identification of Geriatric Patients with Hypovitaminosis D: The ‘Vitamin D Status Predictor for Geriatrics’ Study

Treatment secondary hyperparathyroidoidism in a patient receiving hemodialysis with combination therapy – paricalcitol and cinacalcet

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