Distinction of Neurochemistry between the Cores and Their Shells of Auditory Nuclei in Tetrapod Species

Zeng, Shaoju; Li, Jia; Zhang, Xinwen; Zuo, Mingzhang

doi:10.1159/000101066

Cited by 21 publications

(29 citation statements)

References 154 publications

(117 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The distribution of SERT-ir fibers was relatively homogenous across CMM and NCM, with clusters of fibers appearing to surround unlabeled cell bodies in some individuals. Whereas Zeng et al (2007) reported that MLd in Bengalese finches is nearly devoid of serotonergic fibers, we found that although it was less densely labeled than the surrounding nucleus intercollicularis, it was clearly innervated by SERT-ir fibers (Fig. 5B).…”

Section: Resultscontrasting

confidence: 63%

“…With the exception of Ov, within which only the shell region contained appreciable labeled fibers (see also Belekhova et al, 2002; Kaiser & Covey, 1997; Zeng et al, 2007), the auditory structures we focused on for this study were densely innervated (Fig. 5).…”

Section: Resultsmentioning

confidence: 99%

“…We photographed the three consecutive sections in which Ov was the largest. Because the core region of Ov did not contain SERT-ir fibers (see also Belekhova et al, 2002; Kaiser & Covey, 1997); we included only the shell region in our analysis (Zeng, Li, Zhang, & Zuo, 2007). The Ov shell was traced with the ImageJ freehand tool.…”

Section: Methodsmentioning

confidence: 99%

“…All of the images are from the same female, which had a blank implant (no estradiol). Note that immunolabeling in Ov is limited to the shell region; the core region is relatively devoid of fibers (see also Kaiser & Covey, 1997; Zeng et al, 2007). ICo, nucleus intercollicularis.…”

Section: Figmentioning

confidence: 99%

“…Serotonergic fibers project widely throughout the entire brain, suggesting that like in mammals, this neuromodulator plays important roles in many physiological processes in birds (Cozzi et al, 1991). In the avian species studied so far, serotonergic fibers have been noted in auditory areas (Challet et al, 1996; Kaiser & Covey, 1997; Metzger, Toledo, & Braun, 2002; Zeng et al, 2007). In this study, we aimed to show evidence that in a seasonally breeding songbird, auditory areas are innervated by serotonergic fibers, that the density of this innervation is modulated by plasma E2, and that serotonin is released in the auditory system during the processing of conspecific vocalizations.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Estradiol-dependent modulation of serotonergic markers in auditory areas of a seasonally breeding songbird.

Matragrano

Sanford

Salvante

et al. 2012

Behavioral Neuroscience

View full text Add to dashboard Cite

Because no organism lives in an unchanging environment, sensory processes must remain plastic so that in any context, they emphasize the most relevant signals. As the behavioral relevance of sociosexual signals changes along with reproductive state, the perception of those signals is altered by reproductive hormones such as estradiol (E2). We showed previously that in white-throated sparrows, immediate early gene responses in the auditory pathway of females are selective for conspecific male song only when plasma E2 is elevated to breeding-typical levels. In this study, we looked for evidence that E2-dependent modulation of auditory responses is mediated by serotonergic systems. In female nonbreeding white-throated sparrows treated with E2, the density of fibers immunoreactive for serotonin transporter innervating the auditory midbrain and rostral auditory forebrain increased compared with controls. E2 treatment also increased the concentration of the serotonin metabolite 5-HIAA in the caudomedial mesopallium of the auditory forebrain. In a second experiment, females exposed to 30 min of conspecific male song had higher levels of 5-HIAA in the caudomedial nidopallium of the auditory forebrain than birds not exposed to song. Overall, we show that in this seasonal breeder, (1) serotonergic fibers innervate auditory areas; (2) the density of those fibers is higher in females with breeding-typical levels of E2 than in nonbreeding, untreated females; and (3) serotonin is released in the auditory forebrain within minutes in response to conspecific vocalizations. Our results are consistent with the hypothesis that E2 acts via serotonin systems to alter auditory processing.

show abstract

Section: Resultscontrasting

confidence: 63%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Estradiol-dependent modulation of serotonergic markers in auditory areas of a seasonally breeding songbird.

Matragrano

Sanford

Salvante

et al. 2012

Behavioral Neuroscience

View full text Add to dashboard Cite

show abstract

Evolutionary significance of delayed neurogenesis in the core versus shell auditory areas of Mus musculus

Zeng

Lin

Tian

et al. 2009

J of Comparative Neurology

View full text Add to dashboard Cite

Early comparative embryogenesis can reflect the organization and evolutionary origins of brain areas. Neurogenesis in the auditory areas of sauropsids displays a clear core-to-shell distinction, but it remains unclear in mammals. To address this issue, [3H]-thymidine was injected into pregnant mice on consecutive embryonic (E) days (E10-E19) to date neuronal birthdays. Immunohistochemistry for substance P, calbindin, and parvalbumin was conducted to distinguish the core and shell auditory regions. The results showed that: 1) cell generation began at E13 in the external or dorsal nucleus of the inferior colliculus (IC), but it did not start in the caudomedial portion of the central nucleus of IC, and significantly fewer cells were produced in the medial and rostromedial portions of the central nucleus of IC; 2) cells were generated at E11 in the dorsal and medial divisions of the medial geniculate complex (MGd and MGm, respectively), whereas cell generation was absent in the medial and rostromedial portions of the ventral medial geniculate complex (MGv), and fewer cells were produced in the caudomedial portion of MGv; 3) in the telencephalic auditory cortex, cells were produced at E11 or E12 in layer I and the subplate, which receive projections from the MGd and MGm. However, cell generation occurred at E13-E18 in layers II-VI, including the area receiving projections from the MGv. The core-to-shell distinction of neurogenesis is thus present in the mesencephalic to telencephalic auditory areas in the mouse. This distinction of neurogenesis is discussed from an evolutionary perspective.

show abstract

Sites of origin and developmental dynamics of the neurons in the core and shell regions of torus semicircularis in the chinese softshell turtle (Pelodiscus sinensis)

Chen

Zeng

et al. 2011

J of Comparative Neurology

View full text Add to dashboard Cite

To know the embryogenesis of the core and shell regions of the midbrain auditory nucleus, a single dose of [(3)H]-thymidine was injected into the turtle embryos at peak stages of neurogenesis in the shell and core of the torus semicircularis. Following sequential survival times, labeled neurons and the dynamics of cell proliferation were examined. The expression of vimentin (VM), reelin, calbindin, parvalbumin, and substance P were also studied. The results showed that: 1) progenitor cells for the core and shell regions were generated in different sites of the ventricular zone; 2) the length of the cell cycle or S-phase for the shell region were both longer than those for the core region (4.7 and 3.2 hours longer, respectively), suggesting that mitotic activity in the core region is higher than it is in the shell region; 3) the elongated cell bodies of the labeled core and shell cells had close apposition to VM fibers, suggesting that the migration of these cells is guided by VM fibers; 4) the germinal sites of the core and shell constructed by projecting the orientation of radial VM fibers back to the ventricular zone was consistent with those obtained by short and sequential survival [(3)H]-thymidine radiography; and 5) the beginning of positive staining for parvalbumin in the core region was interposed between those for calbindin and substance P in the shell regions. This study contributes to the understanding of how auditory nuclei are organized and how their components developed and evolved.

show abstract

Distinction of Neurochemistry between the Cores and Their Shells of Auditory Nuclei in Tetrapod Species

Cited by 21 publications

References 154 publications

Estradiol-dependent modulation of serotonergic markers in auditory areas of a seasonally breeding songbird.

Estradiol-dependent modulation of serotonergic markers in auditory areas of a seasonally breeding songbird.

Evolutionary significance of delayed neurogenesis in the core versus shell auditory areas of Mus musculus

Sites of origin and developmental dynamics of the neurons in the core and shell regions of torus semicircularis in the chinese softshell turtle (Pelodiscus sinensis)

Contact Info

Product

Resources

About