Distinction between Porcine Circovirus Type 2 Enteritis and Porcine Proliferative Enteropathy caused by Lawsonia intracellularis

Jensen, Tim Kåre; Vigre, Håkan; Svensmark, Birgitta; Bille‐Hansen, Vivi

doi:10.1016/j.jcpa.2006.08.006

Cited by 68 publications

(78 citation statements)

References 20 publications

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“…Lymphohistiocytic enteritis and anti-PCV2 IS were observed in intestinal samples from all 79 pigs. Most of the PCV2-associated enteric lesions described here were similar to those reported previously , Segalés & Domingo 2004, Jensen et al 2006; however, this report includes additional features in PCV2-associated intestinal changes in PMWS naturally affected pigs. A number of diseases have been associated with swine enteritis.…”

Section: Discussionsupporting

confidence: 87%

“…(Schwartz 1999), PCV2 (Segalés et al 2004, Jensen et al 2006, or both together, the extent to which the lesions described above might be attributed to the bacteria studied, or even to others organinsms not included here remains unknown. The same applies to the viruses studied and the other changes described here.…”

Section: Discussionmentioning

confidence: 96%

“…Varying degrees of necrotizing enteritis were seen in samples from 29 PMWS-affected pigs, of which 17 were immunohistochemically confirmed as co-infected with Salmonella spp. Necrotizing enteritis has typically been linked to swine salmonellosis (Schwartz 1999), but also has been described in PCV2 infection , Segalés et al 2004, Jensen et al 2006. Necrotizing enteritis has also been linked to porcine parvovirus (Duhamel et al 1991), but anti-PPV IS was not observed.…”

Section: Discussionmentioning

confidence: 99%

“…Although especially the former of these changes was not seen, E. coli was detected coinfecting with PCV2 the intestines from 5 pigs. Concurrent infections have frequently been associated with PCV2-enteritis (Carrasco et al 2000, Segalés et al 2001, Ha et al 2005, Jensen et al 2006). In total, bacterial and viral coinfections with PCV2 were identified respectively in samples from 27 and 8 out of the 79 pigs, confirming that concurrent infections are expected in PMWS.…”

Section: Discussionmentioning

confidence: 99%

“…Cases of swine enteritis have been associated with PCV2 alone (Kim et al 2004b, Segalés et al 2004, Jensen et al 2006 or combined with other organisms (Carrasco et al 2000, Segalés et al 2001, Ha et al 2005, Jensen et al 2006. While substantial information has been presented on the pathogenesis of a number of enteric pathogens of pigs (Hampson & Trott 1999, Schwartz 1999, Lawson & Gebhart 2000, the importance and the involvement of some of these organisms in enteric disorders of PMWS-affected pigs remains to be clarified.…”

Section: Introductionmentioning

confidence: 99%

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Intestinal lesions in pigs affected with postweaning multisystemic wasting syndrome

et al. 2008

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RESUMO.-[Lesões entéricas em suínos afetados por síndrome multissistêmica do definhamento dos suínos.]Amostras de linfonodos mesentéricos e intestinos de 79 leitões desmamados refugos, entre 3 e 5 meses de idade e confirmados como naturalmente afetados pela síndrome multissistêmica do definhamento foram estudadas. Os suí-nos eram oriundos de 12 criações no sul do país e foram selecionados em função dos sinais clínicos e/ou lesões macroscópicas sugestivos de doença entérica. Infiltrados linfoistiocíticos de intensidades variáveis foram associados com marcação positiva anti-circovirus suíno tipo 2 (anti-PCV2) em amostras de intestinos e linfonodos mesentéri-cos de todos os 79 animais. Embora a maioria dos achados fossem semelhantes aos descritos em enterite associada com PCV2, marcação imuno-histoquímica anti-PCV2 foi associada com depleção de células caliciformes (24 suínos), atrofia e fusão de vilosidades do íleo (18 suínos) e dilatação de vasos linfáticos (11 suínos) combinada ou não com linfangite. Antígenos de PCV2 foram demonstrados por imuno-histoquímica no citoplasma e núcleo de células epiteliais intralesionais, histiócitos e células tipo endotelial Samples of mesenteric lymph nodes and intestines from 79 unthrifty 3-to 5-monthold postweaning pigs, confirmed as naturally affected with postweaning multisystemic wasting syndrome (PMWS), were studied. Pigs originated from 12 farms in southern Brazil and were selected on the basis of clinical signs and/or gross lesions suggestive of enteric disorder. Lymphohistiocytic infiltrates of varying intensity were associated with anti-porcine circovirus type 2 (anti-PCV2) immunostaining (IS) in samples of intestines and mesenteric lymph nodes from all pigs. Although most findings were similar to those described in PCV2-associated enteritis, anti-PCV2 IS in association with depletion of the goblet cell mucin stores (24 pigs), diffuse ileal villous atrophy and fusion (18 pigs), and dilatation of the lymphatic vessels (11 pigs) combined or not with lymphangitis were also observed. PCV2 antigen was immunohistochemically demonstrated in the cytoplasm and nuclei from intralesional epithelial cells, histiocytes, and endothelial-like cells in intestinal tissues. Together these findings imply an association with PCV2. The presence of co-infections by Lawsonia intracellularis, Brachyspira spp., Mycobacterium spp., Salmonella spp., rotavirus, parvovirus, coronavirus and enteric calicivirus with PCV2 in the intestinal lesions was investigated.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 96%