Distinction between intraductal carcinoma of the prostate (IDC‐P), high‐grade dysplasia (PIN), and invasive prostatic adenocarcinoma, using molecular markers of cancer progression

Dawkins, Hugh; Sellner, Loryn N.; Turbett, Gavin R.; Thompson, Colin A.; Redmond, Sharon L.; McNeal, John E.; Cohen, Ronald Jay

doi:10.1002/1097-0045(20000901)44:4<265::aid-pros1>3.3.co;2-9

Cited by 23 publications

(39 citation statements)

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“…[6][7][8][9][10][11][12] The concept of ductal adenocarcinoma as a specific entity has been challenged, most recently by Bock and Bostwick. 13 In a study utilizing LOH analysis of 12 polymorphic microsatellite markers, frequently lost in prostate cancer, Dawkins et al 14 reported LOH in none of the Gleason grade 3 tumors studied, 9% of high-grade prostatic intraepithelial neoplasia (HGPIN) lesions, 29% of Gleason grade 4 cancers and 60% of ductal adenocarcinomas, suggesting that these are in fact a different lesion.…”

Section: Prostatic Ductal Adenocarcinomamentioning

confidence: 99%

Unusual subtypes of prostate cancer

2004

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The vast majority of prostatic tumors developing in adult males are adenocarcinomas. For the most part, variations in histology have not received specific designations and, from a practical approach, have had any specific prognostic implications handled through application of the Gleason grading system. Nonetheless, some of the adenocarcinoma variants have specific clinical features and differential diagnoses. Furthermore, there has been some controversy regarding the appropriate application of the Gleason grading scheme in these tumors. In addition, there are carcinomas that are in fact not adenocarcinomas and that should be kept as distinct entities. In this paper, the histologic variants of adenocarcinoma are reviewed with emphasis on clinicopathologic features and the clinical relevance of these subtypes. Other carcinomas that occur in the prostate gland are also discussed again with a focus on the clinicopathologic characteristics.

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Section: Prostatic Ductal Adenocarcinomamentioning

confidence: 99%

Unusual subtypes of prostate cancer

2004

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“…Prostate cancer arises from multiple genetic and epigenetic aberrations (7). Common aberrations in human prostate cancer are reduced expression of pRb (8) and frequent inactivation of phosphatase and tensin homologue (PTEN; ref.…”

Section: Introductionmentioning

confidence: 99%

Bevacizumab plus 5-fluorouracil induce growth suppression in the CWR-22 and CWR-22R prostate cancer xenografts

Huynh

2007

Molecular Cancer Therapeutics

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Prostate cancer is the most common malignancy in men. Although patients with metastatic prostate cancer can benefit from androgen ablation, most of them will die of prostate cancer progression to an androgen-refractory state. In the present study, the effects of docetaxel, bevacizumab, 5-fluorouracil (5-FU), bevacizumab plus docetaxel, and bevacizumab plus 5-FU on the growth of human CWR-22 (androgen-dependent) and CWR-22R

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“…A number of clinic tests, including the measurement of the serum level of prostate specific antigen (PSA), MRI, and gene expression profiling, are increasingly used in the clinic, whereas none of those could predict which of the PIN lesions will progress [24][25][26][27][28][29]. The only established approach to monitor PIN progression is repeat biopsy [25][26][27][28][29], which is costly and painful.…”

Section: Focal Basal Cell Alterations and Disruptions In Tumor Capsulesmentioning

confidence: 99%

“…The only established approach to monitor PIN progression is repeat biopsy [25][26][27][28][29], which is costly and painful. Since over 90% of prostate cancer related mortality result from invasion-related illnesses, and the incidence of PIN could be up to 16.5%-25% in routine or ultrasound guided prostate biopsies [25][26][27][28][29], there is an urgent need to uncover the intrinsic mechanism of tumor invasion, and to develop novel approaches to identify the specific precursor of invasive prostate lesions.…”

Section: Focal Basal Cell Alterations and Disruptions In Tumor Capsulesmentioning

confidence: 99%

A seemingly most effective target for early detection and intervention of prostate tumor invasion

Man¹

2010

J. Cancer

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Distinction between intraductal carcinoma of the prostate (IDC‐P), high‐grade dysplasia (PIN), and invasive prostatic adenocarcinoma, using molecular markers of cancer progression

Cited by 23 publications

References 0 publications

Unusual subtypes of prostate cancer

Unusual subtypes of prostate cancer

Bevacizumab plus 5-fluorouracil induce growth suppression in the CWR-22 and CWR-22R prostate cancer xenografts

A seemingly most effective target for early detection and intervention of prostate tumor invasion

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