Distinct uric acid trajectories are associated with incident diabetes in an overweight Chinese population

Li, Fēi; Duan, Jingwen; Yang, Yiping; Yang, Guangyu; Chen, Zhiheng; Yuan, Hong; Lu, Yao

doi:10.1016/j.diabet.2020.07.002

Cited by 16 publications

(13 citation statements)

References 34 publications

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“…[ 14 ] This condition is implicated in the underlying mechanism of hyperuricemia and the occurrence of diabetes, and it plays a crucial role in the pathogenesis of diabetes. [ 8 50 51 52 53 54 55 ] This finding supports the hypothesis that serum UA might be involved in the early stages of impaired glucose metabolism leading to prediabetes and accelerating the development of diabetes.…”

Section: Discussionsupporting

confidence: 76%

Association between serum uric acid with diabetes and other biochemical markers

Alasmary

Alqahtani

Awan³

et al. 2022

Journal of Family Medicine and Primary Care

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Objective: This study aimed to decipher the association between serum uric acid (UA) and glycated hemoglobin (HbA1c) in the population from the southern region of Saudi Arabia. Method: In this retrospective cross-sectional investigation, clinical data obtained from the different commercial laboratories in the Asir region of Saudi Arabia were screened over 2 years. Data were analyzed using standard statistical methods. Results: A total of 1984 laboratory investigations with 1215 females (61.2%) and 769 males (38.6%) were included in the data analysis. In our investigation, the prevalence of hyperuricemia in the study population was 53.5% (41.2% females and 12.3% males) and in the diabetic population was 12.7% (9.47% females and 3.23% males), in prediabetics was 12.65% (9.8% females and 2.85% males), respectively. Prediabetic subjects had higher UA levels than people with diabetes or healthy people. Higher UA quartiles were associated with a high level of urea, blood urea nitrogen (BUN) creatinine, HbA1c, fasting blood sugar (FBS), and total cholesterol (TC) ( P < 0.05). High UA (OR = 1.33 for diabetes; OR = 2.676 for prediabetes), high BUN (OR = 3.05 for diabetes; OR = 2.293 for prediabetes), high TC (OR = 3.75 for diabetes; OR = 1.098 for prediabetes), and high TG (OR = 2.67 for diabetes; OR = 1.943 for prediabetes) parameters are the most influential risk factor in diabetic and prediabetic patients than the people who have normal UA, BUN, TC, and TG value. Conclusion: High UA levels are significantly associated with prediabetes as defined by HbA1c criteria, indicating that UA has a significant role in the disturbance of glucose metabolism. A significant positive association was observed between dyslipidemia and serum UA in the study population.

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Section: Discussionsupporting

confidence: 76%

Association between serum uric acid with diabetes and other biochemical markers

Alasmary

Alqahtani

Awan³

et al. 2022

Journal of Family Medicine and Primary Care

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“…Some people suggested that its increase was related to the increase of body weight and blood pressure [ 19 ]. Higher UA is significantly associated with increased risk of diabetes, especially among overweight people [ 20 ]. HbA1c reflects the average blood glucose level of the body for three months, and it is also an important indicator of diabetes diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Metabolic indexes of obesity in patients with common mental disorders in stable stage

Xiao

Tan

et al. 2022

BMC Psychiatry

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Background Obesity is a serious worldwide public health problem, especially for people with mental disorders. Aim To explore the related factors of obesity by analyzing the metabolic indexes of patients with common mental disorders in stable stage. Methods Five hundred seventy-six subjects with major depressive disorder (MDD), bipolar disorder (BD) or schizophrenia (SCZ) were included, who received fixed drug dose and routine drug treatment for 2 years or more. Their venous blood was collected, and the blood metabolic indexes were analyzed. Results BD and SCZ are more prone to obesity than MDD. Multiple linear regression analysis showed that the value of BMI increased with the increase of age(B = 0.084, p < 0.001), TG(B = 0.355, p = 0.024), LDL(B = 0.697, p < 0.001), LDH(B = 0.011, p = 0.002), SCr(B = 0.051, p < 0.001), UA(B = 0.014, p < 0.001), HbA1c(B = 0.702, p = 0.004) and hsCRP(B = 0.101, p < 0.001). And It decreased with the increase of HDL(B = -1.493, p < 0.001). Discussion People with mental disorders should regularly check blood indicators and strengthen weight management to reduce the risk of obesity and promote their health.

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“…However, the effect of UA was well recognized, and some people believed that its increase was related to the increase of weight and blood pressure [26]. What's more, its increase was signi cantly associated with increased risk of diabetes, especially for overweight people [27]. HbA1c is considered to be a re ection of the average blood glucose level in the body for three months.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Indexes of Obesity in Major Depressive Disorders

et al. 2022

Preprint

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Background Major depressive disorder (MDD) is a chronic common mental disorder. Long-term medication may lead to abnormalities in vivo factors, which cause obesity.Aim To find out the related factors of obesity by analyzing the metabolic indexes of patients with major depressive disorders of all ages in stable stage.Methods Subjects with major depressive disorder (MDD) were treated with fixed dose drugs and conventional drugs for 2 years or more. Venous blood was collected and blood metabolic indexes were analyzed.Results Among MDD, with the increase of age, the risk of obesity increases. Body mass index (BMI) was positively correlated with age, total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), uric acid (UA), alanine aminotransferase (ALT), glycosylated hemoglobin (HbA1c) and high sensitivity C-reactive protein (HsCRP), and high density lipoprotein (HDL). But creative kinase isoenzyme (CK-MB), urea, serum creatinine (SCr) and homocysteine (Hcy) were not correlated with BMI. Multiple linear regression analysis showed that the value of BMI increased with the increase of age (B = 0.050, p = 0.002), AST (B = 0.094, p = 0.049), ALT (B = 0.055, p = 0.016), UA (B = 0.006, p < 0.021), HbA1c (B = 0.702, p = 0.004) and hsCRP (B = 0.101, p < 0.001). Discussion We should pay more attention to the monitoring of blood metabolism indicators with the increase of age in MDD, and timely adjust the use of drugs timely adjust the use of drugs refer to their liver and kidney function, so as to reduce the risk of obesity and improve their quality of life.

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Distinct uric acid trajectories are associated with incident diabetes in an overweight Chinese population

Cited by 16 publications

References 34 publications

Association between serum uric acid with diabetes and other biochemical markers

Association between serum uric acid with diabetes and other biochemical markers

Metabolic indexes of obesity in patients with common mental disorders in stable stage

Metabolic Indexes of Obesity in Major Depressive Disorders

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