Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae

Snapper, Clifford M.; Shen, Yi; Khan, Abdul Qayyum; Colino, Jesus; Żelazowski, Piotr; Mond, James J.; Gause, William C.; Wu, Zheng-Qi

doi:10.1016/s1471-4906(01)01926-3

Cited by 39 publications

(27 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, we define the mechanism by which immunization with MDA-LDL led to expansion of T15/EO6 antibodies. Because the expansion of the B-1 cell-derived T15/EO6 is independent of classic cognate T-cell help (30), it was unclear how the TD response to MDA-LDL led to increased T15/EO6 titers. In these studies, we demonstrate that the induced Th2 cells produced large amounts of IL-5, which in turn provided noncognate stimulation of B-1 cells to secrete the innate T15/EO6 IgM antibodies (7,12).…”

Section: Discussionmentioning

confidence: 99%

“…B-1 cells are the major source of natural IgM antibodies and are prominently involved in TI responses (48). Because multivalent cross-linking of the B cell receptor is not sufficient to drive optimal antibody production, it has been suggested that noncognate interactions with T cells, NK cells and other cells enhance these responses (30). The exact mechanisms underlying such noncognate T cell help are still unknown, but T cells, once activated, could either directly or indirectly costimulate B1 cells.…”

Section: Discussionmentioning

confidence: 99%

“…Although the secretion of B-1 cell-dependent IgM antibodies is known to be T cell independent, T cells are thought to provide noncognate help for B-1 cells (30), and IL-5 has been described as an important factor in B-1 cell biology (31,32).…”

Section: Il-5 Stimulates B-1 Cells To Secrete Natural Antibody T15/eo6mentioning

confidence: 99%

See 2 more Smart Citations

IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

Binder

Hartvigsen²,

Chang³

et al. 2004

J. Clin. Invest.

253

241

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

Binder

Hartvigsen²,

Chang³

et al. 2004

J. Clin. Invest.

253

241

View full text Add to dashboard Cite

“…Wu et al (18), using CD40L knockout mice, reported that the IgG response against phosphorylcholine (a TI-2 Ag) in mice immunized with a nonencapsulated variant of S. pneumoniae is T lymphocyte and CD40L dependent. However, it has also been described that a blocking anti-CD40L Ab (MR1) had little or only modest effect on the antiphosphorylcholine response and that CD40 Ϫ/Ϫ dendritic cells elicited an anti-phosphorylcholine response that was comparable to that observed for wild-type dendritic cells (19). Szomolanyi-Tsuda et al (20) stressed the role of the CD40-CD154 interaction in anti-polyoma virus thymus cell-independent IgG responses.…”

mentioning

confidence: 99%

Essential Role for CD40 Ligand Interactions in T Lymphocyte-Mediated Modulation of the Murine Immune Response to Pneumococcal Capsular Polysaccharides

Jeurissen¹,

Wuyts²,

Kasran

et al. 2002

The Journal of Immunology

View full text Add to dashboard Cite

Protection against infection with pneumococci is provided by anti-capsular polysaccharide (caps-PS) Abs. We investigated whether CD40 ligand (CD40L) plays a role in T lymphocyte-mediated regulation of the immune response to caps-PS, which are considered thymus-independent Ags. Administration of MR1, an antagonist mAb against murine CD40L, in BALB/c mice immunized with Pneumovax resulted in an inhibition of the IgM and IgG Ab response for various caps-PS serotypes. Evidence for the involvement of CD4+ T lymphocytes in the Ab response to caps-PS was obtained in SCID/SCID mice that, when reconstituted with B lymphocytes and CD4+ T lymphocytes, mounted a higher specific IgM response compared with SCID/SCID mice reconstituted with only B lymphocytes. This helper effect of CD4+ T lymphocytes was abrogated by MR1. Blocking CD40L in vitro decreased the IgM response to caps-PS and abolished the helper effect of CD4+ T lymphocytes. CD8+ T lymphocyte-depleted murine spleen cells mounted a higher in vivo immune response than total murine spleen cells, which provided evidence for a suppressive role of CD8+ T lymphocytes on the anti-caps-PS immune response. CD4+ T lymphocyte-depleted murine spleen cells, leaving a B and CD8+ T lymphocyte fraction, elicited only a weak in vivo and in vitro Ab response, which was enhanced after MR1 administration. In summary, our data provide evidence that T lymphocytes contribute to the regulation of the anti-caps-PS immune response in a CD40L-dependent manner.

show abstract

“…These 7 genes are b-defensin 1 (DEFB1) with 7 associated SNPs; toll-like receptor 1 (TLR1) and interleukin 1 receptor-like 1 (IL1RL1) each with 2 associated SNPs; cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), mitogen-activated protein kinase 8 (MAPK8), cluster of differentiation 86-a molecule expressed on antigen-presenting cells that provide costimulatory signals necessary for T cell activation Table 6 Details of 8 SNPs in 7 Genes that showed significant cross-validated association with antibody response, and of other assayed SNPs in those genes that showed significant association in both half-samples and survival (CD86) and interleukin 17D (IL17D) each with 1 associated SNP. Though the role of T lymphocytes in the regulation of the antibody production to PS is obscure, anti-PS response involves non-cognate activation of TCR-nonspecific T cells by implicating a role for endogenous CD40-CD40L interactions in the human antibody response (Snapper et al 2001). It is known that B7 family of co-stimulatory molecules, CD86 along with CD80, present on the antigenpresenting cells (APCs), interact with CD28/CTLA4 receptors on T cells to provide major non-cognate costimulatory signals (Khan et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Genetic determinants of immune-response to a polysaccharide vaccine for typhoid

Majumder

Staats

Sarkar-Roy

et al. 2009

HUGO J

View full text Add to dashboard Cite

Differences in immunological response among vaccine recipients are determined both by their genetic differences and environmental factors. Knowledge of genetic determinants of immunological response to a vaccine can be used to design a vaccine that circumvents immunogenetic restrictions. The currently available vaccine for typhoid is a pure polysaccharide vaccine, immune response to which is T-cell independent. Little is known about whether genetic variation among vaccinees associates with variation in their antibody response to a polysaccharide vaccine. We conducted a study on 1,000 individuals resident in an area at high-risk for typhoid; vaccinated them with the typhoid vaccine, measured their antibody response to the vaccine, assayed [2,000 curated SNPs chosen from 283 genes that are known to participate in immune-response; and analyzed these data using a strategy to (a) minimize the statistical problems associated with testing of multiple hypotheses, and (b) internally cross-validate inferences, using a half-sample design, with little loss of statistical power. The first stage analysis, using the first half-sample, identified 54 SNPs in 43 genes to be significantly associated with immune response. In the second-stage, these inferences were cross-validated using the second half-sample. First-stage results of only 8 SNPs (out of 54) in 7 genes (out of 43) were cross-validated. We tested additional SNPs in these 7 genes, and found 8 more SNPs to be significantly associated. Haplotypes constructed with these SNPs in these 7 genes also showed significant association. These 7 genes are DEFB1, TLR1, IL1RL1, CTLA4, MAPK8, CD86 and IL17D. The overall picture that has emerged from this study is that (a) immune response to polysaccharide antigens is qualitatively different from that to protein antigens, and (b) polymorphisms in genes involved in polysaccharide recognition, signal transduction, inhibition of T-cell proliferation, pro-inflammatory signaling and eventual production of antimicrobial peptides are associated with antibody response to the polysaccharide vaccine for typhoid.

show abstract

Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae

Cited by 39 publications

References 35 publications

IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis

Essential Role for CD40 Ligand Interactions in T Lymphocyte-Mediated Modulation of the Murine Immune Response to Pneumococcal Capsular Polysaccharides

Genetic determinants of immune-response to a polysaccharide vaccine for typhoid

Contact Info

Product

Resources

About