Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19
Glenda Canderan,
Lyndsey M. Muehling,
Alexandra Kadl
et al.
Abstract:The variable etiology of persistent breathlessness after COVID-19 have confounded efforts to decipher the immunopathology of lung sequelae. Here, we analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease. Cluster analysis of lung physiology measures highlighted two phenotypes of restrictive lung disease that differed by their impaired diffusion and severity of fibrosis. Machine learning revealed mar… Show more
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