Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected
Kelvin M. Kimenyi,
Mercy Y. Akinyi,
Kioko Mwikali
et al.
Abstract:Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections. There is limited information on how host-parasite interactions mediate maintenance of chronic symptomless infections that sustain malaria transmission. Here, we have determined the gene expression profiles of the parasite population and the corresponding host peripheral blood mononuclear cells (PBMCs) from 21 children (< 15 years). We compared children who were defined as… Show more
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