Distinct transcriptional profiles characterize bone microenvironment mesenchymal cells rather than osteoblasts in relationship with multiple myeloma bone disease

Myeloma plasma cells alter the bone marrow microenvironment by stimulating the proliferation of mesenchymal stromal cells

“…[13][14][15] Notably, these genetic differences were not found in MM patient-derived OB, 15 indicating that MSC may represent a key stromal cell population with the capacity to influence the growth of malignant MM PC. This has led investigators to examine whether MM patients show evidence of elevated MSC numbers following MM PC infiltration into the BM.…”

Mesenchymal stem cells expressing osteoprotegerin variants inhibit osteolysis in a murine model of multiple myeloma

“…30 Although MSCs in the bone microenvironment produce OPG to prevent excess osteoclast activation, upon osteolytic tumor growth, the homeostasis shifts toward less OPG production. 44 Furthermore, because of a decreased osteogenic potential of MSCs in myeloma, [45][46][47] the osteoprogenitor cell source becomes limited to remodel bone following aggressive osteoclast damage. During this shift in balance that negatively affects OPG level, 44 supplementation of MSCs overexpressing OPG offers a dual benefit to decreasing osteoclast activation and providing additional source of osteoprogenitors.…”

Participation of Cultured Mesenchymal Multipotent Stromal Cells in Regeneration of a Large Persisting Defect of Rabbit Radius Bone

“…where N H is the number of harvested cells at the end of the growth period, and N S the number of seeded cells [18].…”