Distinct suppressing effects of deep brain stimulation in the orbitofrontal cortex on the development, extinction, and reinstatement of methamphetamine-seeking behaviors

Fattahi, Mojdeh; Eskandari, Kiarash; Riahi, Esmail; Khosrowabadi, Reza; Haghparast, Abbas

doi:10.1016/j.lfs.2023.121613

Cited by 10 publications

(2 citation statements)

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“…The OFC plays a fundamental role in motivated behavior, and deficits in its function elicit not only impulsive but also compulsive behaviors, which may underlie the mechanism of compulsive drug seeking and relapse [ 37 , 38 ]. In line with our findings, high-frequency DBS of the OFC has also been shown to reduce the methamphetamine-induced reinstatement of seeking behaviors [ 39 ].…”

Section: Discussionsupporting

confidence: 89%

High frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats

Zhang,

Meng,

Huang

et al. 2024

Transl Psychiatry

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Drug addiction represents a multifaceted and recurrent brain disorder that possesses the capability to create persistent and ineradicable pathological memory. Deep brain stimulation (DBS) has shown a therapeutic potential for neuropsychological disorders, while the precise stimulation targets and therapeutic parameters for addiction remain deficient. Among the crucial brain regions implicated in drug addiction, the dorsal raphe nucleus (DRN) has been found to exert an essential role in the manifestation of addiction memory. Thus, we investigated the effects of DRN DBS in the treatment of addiction and whether it might produce side effects by a series of behavioral assessments, including methamphetamine priming-induced reinstatement of drug seeking behaviors, food-induced conditioned place preference (CPP), open field test and elevated plus-maze test, and examined brain activity and connectivity after DBS of DRN. We found that high-frequency DBS of the DRN significantly lowered the CPP scores and the number of active-nosepokes in the methamphetamine-primed CPP test and the self-administration model. Moreover, both high-frequency and sham DBS group rats were able to establish significant food-induced place preference, and no significant difference was observed in the open field test and in the elevated plus-maze test between the two groups. Immunofluorescence staining and functional magnetic resonance imaging revealed that high-frequency DBS of the DRN could alter the activity and functional connectivity of brain regions related to addiction. These results indicate that high-frequency DBS of the DRN effectively inhibits methamphetamine priming-induced relapse and seeking behaviors in rats and provides a new target for the treatment of drug addiction.

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