“…The shared oncogenic drivers comprised a major MET-RAS hub (Met, Prlr, Nf1, Map3k3, Stat5b, and Notch1) known to promote tumor growth and cell migration [30][31][32], as well as Jup/Plakoglobin/gamma-catenin, involved in collective cell migration [33]. The metastasis-specific drivers formed three additional hubs: Rho signaling (migration; Srgap2, Cdc42bpa/Mrcka, and Wasf2/Wave2), ubiquitination (e.g., Fbxw4, Ubxn7, Spop, Hectd1, and Ube2d3) and RNA processing (Wdr33, Cwc22, Cdc5l, Prpf6, and Pspc1) [21]. We showed that the expression of these metastatic hub genes correlates with poor prognosis in breast cancer and validated representatives of each hub for promoting hallmarks of metastasis such as cell migration, as well as cell proliferation and/or tumorigenesis.…”