Distinct Roles of Honeybee Gut Bacteria on Host Metabolism and Neurological Processes

Zhang, Zijing; Mu, Xiaohuan; Shi, Yiting; Zheng, Hao

doi:10.1128/spectrum.02438-21

Cited by 36 publications

(35 citation statements)

References 60 publications

(89 reference statements)

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“…Finally, there are methodological discrepancies with the previous study by Zhang et al 34 : (i) they considered the first presentation of water as a sucrose dilution, which indicates thirst or overall sensitivity to antennal stimulation rather than sucrose responsiveness; (ii) they eliminated bees that did not respond to the highest sucrose concentration, which is a variable that can be affected by the bacterial treatment and is part of the sucrose responsiveness assay;…”

Section: Discussionmentioning

confidence: 89%

“…The copyright holder for this preprint this version posted January 4, 2023. ; https://doi.org/10.1101/2023.01.03.522593 doi: bioRxiv preprint and (iii) they assumed that bees responding to a given concentration of sucrose would also respond to higher concentrations when computing the SRS, which ignores the possibility that some bees responded randomly to the presented stimuli. The method used by Zhang et al 34 might have led to an overestimation of the SRS in colonized bees who massively responded to the first presentation of water. An analyses of water responses may have revealed differences in habituation and sensitization to antennal stimulation accounting for the differences in SRS.…”

Section: Discussionmentioning

confidence: 99%

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A defined community of core gut microbiota members promotes cognitive performance in honey bees

Cabirol

Schafer

Neuschwander

et al. 2023

Preprint

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The composition of the gut microbiota has recently been identified as a cause of cognitive variability in humans and animals. Germ-free individuals and individuals exposed to an antibiotic treatment show severe alteration of their learning and memory performance measured in various cognitive tasks. While different species of bacteria are known to interact in the gut, their cumulative or synergistic effects on cognitive performance remain elusive. Here we established a defined bacterial community - composed of core members of the corbiculate bee microbiota - which enhances honey bee cognitive capacities. Honey bees colonized with this reconstituted community discriminated better two odours based on the presence or absence of a sucrose reward compared to germ-free individuals. They also memorized better these odour-food associations in the short-term. These cognitive improvements seem to constitute an emergent property of the community, because they could not be recapitulated by any of the community member when mono-associated in gnotobiotic bees and they were not explained by the total biomass in the gut. The identification of this community and its effect on bees open new avenues of research in neuroscience, microbiology, and ecology. Future research should help understanding how interactions between bacterial species in the community promote the host associative learning and memory performance.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

A defined community of core gut microbiota members promotes cognitive performance in honey bees

Cabirol

Schafer

Neuschwander

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…At the same time, Lactobacillus in the gut was strongly associated with tryptophan metabolites, consistent with studies showing that Lactobacillus can metabolize tryptophan to produce indole-3-carboxaldehyde ( Natividad et al, 2018 ). Zhang et al (2022a , b) also found that Lactobacillus in the honeybee gut modulates host learning and memory behaviors via tryptophan metabolism regulation.…”

Section: Discussionmentioning

confidence: 95%

Multi-omics analysis reveals the host–microbe interactions in aged rhesus macaques

Xu¹,

Lan

Wang

et al. 2022

Front. Microbiol.

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Aging is a complex multifactorial process that greatly affects animal health. Multi-omics analysis is widely applied in evolutionary biology and biomedical research. However, whether multi-omics can provide sufficient information to reveal comprehensive changes in aged non-human primates remains unclear. Here, we explored changes in host–microbe interactions with aging in Chinese rhesus macaques (Macaca mulatta lasiota, CRs) using multi-omics analysis. Results showed marked changes in the oral and gut microbiomes between young and aged CRs, including significantly reduced probiotic abundance and increased pathogenic bacterial abundance in aged CRs. Notably, the abundance of Lactobacillus, which can metabolize tryptophan to produce aryl hydrocarbon receptor (AhR) ligands, was decreased in aged CRs. Consistently, metabolomics detected a decrease in the plasma levels of AhR ligands. In addition, free fatty acid, acyl carnitine, heparin, 2-(4-hydroxyphenyl) propionic acid, and docosahexaenoic acid ethyl ester levels were increased in aged CRs, which may contribute to abnormal fatty acid metabolism and cardiovascular disease. Transcriptome analysis identified changes in the expression of genes associated with tryptophan metabolism and inflammation. In conclusion, many potential links among different omics were found, suggesting that aged CRs face multiple metabolic problems, immunological disorders, and oral and gut diseases. We determined that tryptophan metabolism is critical for the physiological health of aged CRs. Our findings demonstrate the value of multi-omics analyses in revealing host–microbe interactions in non-human primates and suggest that similar approaches could be applied in evolutionary and ecological research of other species.

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“…Several studies have linked gut microbiome status to caste and behavior in honey bees (Kapheim et al, 2015;Jones et al, 2018); others have asked if the gut microbiome modulates learning and memory, a topic of intense interest in translational neuroscience (Mao et al, 2020;Tang et al, 2021). A study of bumblebees showed no change in performance on a color discrimination associative learning task in bumblebees with a reduced gut microbiome (Leger and McFrederick, 2020), but new studies of a possible gut-gut microbiome-brain-behavior axis are being published even as I prepare this piece (Zhang et al, 2022). Again, it is pertinent to ask if a baseline set of techniques for assessment of perturbations in foraging, learning, and memory would be useful in terms of risk assessment and understanding the links across different systems.…”

Section: Bee Guts In the 21 St Centurymentioning

confidence: 99%

Specialty grand challenge – Building a 21st century community of bee physiologists to tackle 21st century challenges to bee thriving

Fahrbach

2023

Front. Bee Sci.

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Distinct Roles of Honeybee Gut Bacteria on Host Metabolism and Neurological Processes

Cited by 36 publications

References 60 publications

A defined community of core gut microbiota members promotes cognitive performance in honey bees

A defined community of core gut microbiota members promotes cognitive performance in honey bees

Multi-omics analysis reveals the host–microbe interactions in aged rhesus macaques

Specialty grand challenge – Building a 21st century community of bee physiologists to tackle 21st century challenges to bee thriving

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