Distinct role of non-covalent interactions to the function and structural stability of glutaredoxins: a multifunctional redox protein

Bartenschlager, Ralf; Tripathi, Bhumi Nath; Sethumadhavan, Rao

doi:10.1504/ijbra.2010.034073

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…A distinct role of non-covalent interactions in the function and structural stability of glutaredoxins was investigated. 194 Among the proteins, an average of 1 CH-p hydrogen bond per 16 residues has been found. These interactions were influenced by long-range contacts, whereas short-and medium-range contacts were found to be insignificant.…”

Section: Other Topicsmentioning

confidence: 99%

CH–π hydrogen bonds in biological macromolecules

Nishio¹,

Umezawa

Fantini

et al. 2014

Phys. Chem. Chem. Phys.

424

283

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This is a sequel to the previous Perspective "The CH-π hydrogen bond in chemistry. Conformation, supramolecules, optical resolution and interactions involving carbohydrates", which featured in a PCCP themed issue on "Weak Hydrogen Bonds - Strong Effects?": Phys. Chem. Chem. Phys., 2011, 13, 13873-13900. Evidence that weak hydrogen bonds play an enormously important role in chemistry and biochemistry has now accumulated to an extent that the rigid classical concept of hydrogen bonds formulated by Pauling needs to be seriously revised and extended. The concept of a more generalized hydrogen bond definition is indispensable for understanding the folding mechanisms of proteins. The CH-π hydrogen bond, a weak molecular force occurring between a soft acid CH and a soft base π-electron system, among all is one of the most important and plays a functional role in defining the conformation and stability of 3D structures as well as in many molecular recognition events. This concept is also valuable in structure-based drug design efforts. Despite their frequent occurrence in organic molecules and bio-molecules, the importance of CH-π hydrogen bonds is still largely unknown to many chemists and biochemists. Here we present a review that deals with the evidence, nature, characteristics and consequences of the CH-π hydrogen bond in biological macromolecules (proteins, nucleic acids, lipids and polysaccharides). It is hoped that the present Perspective will show the importance of CH-π hydrogen bonds and stimulate interest in the interactions of biological macromolecules, one of the most fascinating fields in bioorganic chemistry. Implication of this concept is enormous and valuable in the scientific community.

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Section: Other Topicsmentioning

confidence: 99%

CH–π hydrogen bonds in biological macromolecules

Nishio¹,

Umezawa

Fantini

et al. 2014

Phys. Chem. Chem. Phys.

424

283

View full text Add to dashboard Cite

show abstract

Антиоксидантна Система Респіраторного Тракту. Внутрішньоклітинний Антиоксидантний Захист У Респіраторному Тракті (Частина 5)

Абатуров¹,

Волосовец²,

Borysovа³

2021

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В огляді літератури викладено сучасні дані щодо системи глутаредоксинів у функціонуванні внутрішньоклітинного антиоксидантного захисту в респіраторному тракті. Детально розглянуто глутаредоксинзалежні окислювально-відновні реакції.

show abstract

Distinct role of non-covalent interactions to the function and structural stability of glutaredoxins: a multifunctional redox protein

Cited by 2 publications

References 41 publications

CH–π hydrogen bonds in biological macromolecules

CH–π hydrogen bonds in biological macromolecules

Антиоксидантна Система Респіраторного Тракту. Внутрішньоклітинний Антиоксидантний Захист У Респіраторному Тракті (Частина 5)

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