Distinct Regulatory Mechanisms for Interferon-α/β (IFN-α/β)– and IFN-γ–Mediated Induction of Ly-6E Gene in B Cells

Khodadoust, Mehran M.; Khan, Khuda Dad; Park, Eunha; Bothwell, Alfred L.M.

doi:10.1182/blood.v92.7.2399.2399_2399_2409

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…Ly‐6 members have been implicated in cellular activation during hematopoiesis from multipotential stem cells to lineage‐committed precursor cells (27) . Furthermore, Ly‐6 family members have been shown to be induced transcriptionally by interferons in distinct cell types (28) . Interferons have been shown to inhibit osteoclastogenesis (29, 30) .…”

Section: Discussionmentioning

confidence: 99%

Identification of the Functional Domain of Osteoclast Inhibitory Peptide-1/hSca

Koide

Kurihara

Maeda

et al. 2002

Journal of Bone and Mineral Research

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Section: Discussionmentioning

confidence: 99%

Identification of the Functional Domain of Osteoclast Inhibitory Peptide-1/hSca

Koide

Kurihara

Maeda

et al. 2002

Journal of Bone and Mineral Research

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“…In this context murine Ly6e , the Ly6 gene immediately flanking upstream the Ly6a subfamily cluster (see Fig. 1, panel a) is a well-known ISG ( 33 ), that has recently been shown to differentially regulate infection with dependence on virus, acting on the one hand as a pan restriction factor of zoonotic coronaviruses ( 34 ), while enhancing infection of Influenza virus, West Nile virus or VSV, on the other ( 35 ) ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

LY6S, a New Interferon-Inducible Human Member of the Ly6a-Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

Shmerling

Chalik

Smorodinsky

et al. 2021

Preprint

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Syntenic genomic loci on human chromosome 8 (hChr8) and mouse chromosome 15 (mChr15) code for LY6/Ly6 (lymphocyte antigen 6) family proteins. The 23 murine Ly6 family genes include eight genes that are flanked by the murine Ly6e and Ly6l genes and form an Ly6 subgroup referred to here as the Ly6a subfamily gene cluster. Ly6a, also known as Sca1 (Stem Cell Antigen-1) and TAP (T-cell activating protein), is a member of the Ly6a subfamily gene cluster. No LY6 genes have been annotated within the syntenic LY6E to LY6L human locus. We report here on LY6S, a solitary human LY6 gene that is syntenic with the murine Ly6a subfamily gene cluster, and with which it shares a common ancestry. LY6S codes for the interferon-inducible GPI-linked LY6S-iso1 protein that contains only 9 of the 10 consensus LY6 cysteine residues and is most highly expressed in a non-classical cell population. Its expression leads to distinct shifts in patterns of gene expression, particularly of genes coding for inflammatory and immune response proteins, and LY6S-iso1 expressing cells show increased resistance to viral infection. Our findings reveal the presence of a previously un-annotated human interferon-stimulated gene, LY6S, which has a one to eight ortholog relationship with the genes of the Ly6a subfamily gene cluster, is most highly expressed in spleen cells of a non-classical cell-lineage and whose expression induces viral resistance and is associated with an inflammatory phenotype and with the activation of genes that regulate immune responses.One Sentence SummaryLY6S is a newly discovered human interferon-inducible gene associated with inflammation and with resistance to viral replication.

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Peripheral Mononuclear Cell Response in Japanese Black Calves after Oral Administration of IFN-.ALPHA.

Ohtsuka

Tokita

Takahashi³

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. To investigate the effects of oral administration of an interferon (IFN)-α drug on the immune reaction of healthy Japanese Black (JB) calves, peripheral leukocyte populations and their ability to produce cytokine mRNA were analyzed after oral administration of IFN-α. Fourteen calves fed in one herd were divided into two groups; seven calves were orally administered 0.1 g/day of IFN-α from the day of birth to day 5 on each day (group 1, N=7), and the other seven calves were used as the control (group 2, N=7). Blood samples were collected from the jugular veins of all calves before administration and in weeks 1, 2, 4, 8, and 16 after birth. The number of MHC class II + CD14 + monocytes in the leukocytes population of group 1 increased gradually after birth, and significantly higher numbers were detected in week 4 compared with group 2. MHC class II -CD14 + monocytes in group 1 peaked in week 1, and a significant increase was detected compared with group 2. The level of IL-12 in the cytokine mRNA of group 1 increased gradually between weeks 1 and 2, and a significantly higher level of IL-12 was found compared with group 2. These results suggest that oral administration of IFN-α induces activation of the monocyte functions in JB calves. KEY WORDS: cytokine production, interferon-α, Japanese Black calf, leukocyte population.

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Distinct Regulatory Mechanisms for Interferon-α/β (IFN-α/β)– and IFN-γ–Mediated Induction of Ly-6E Gene in B Cells

Cited by 6 publications

References 37 publications

Identification of the Functional Domain of Osteoclast Inhibitory Peptide-1/hSca

Identification of the Functional Domain of Osteoclast Inhibitory Peptide-1/hSca

LY6S, a New Interferon-Inducible Human Member of the Ly6a-Subfamily Expressed by Spleen Cells and Associated with Inflammation and Viral Resistance

Peripheral Mononuclear Cell Response in Japanese Black Calves after Oral Administration of IFN-.ALPHA.

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