Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity

Rachid, Briana; Sande‐Lee, Simone van de; Rodovalho, S.; Folli, Franco; Beltramini, Guilherme C.; Morari, Joseane; Amorim, Bárbara Juarez; Pedro, Tatiane; Ramalho, Albina F.; Bombassaro, Bruna; Tincani, Álfio José; Chaim, Élinton Adami; Pareja, José Carlos; Geloneze, Bruno; Ramos, Celso Darío; Cendes, Fernando; Saad, Mário José Abdalla; Velloso, Lı́cio A.

doi:10.1038/ijo.2015.94

Cited by 45 publications

(39 citation statements)

References 46 publications

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“…Some individuals showed increases, whereas others showed no change or decreases in UCP1 and browning marker expression ( Figures 4A-4D, right, middle, and left, respectively). These inter-individual differences in WAT gene expression are coherent with the reported variability of response in BAT activity and WAT UCP1 mRNA expression during weight loss of a few individuals (Oliveira et al, 2016;Orava et al, 2013;Rachid et al, 2015;Vijgen et al, 2012;Nakhuda et al, 2016). Despite markedly different regulation of gene expression, the decrease in body fat (12%-13%) was similar in the three groups ( Figure 4E).…”

Section: Gene Expression Of Brown and Beige Markers In Subcutaneous Asupporting

confidence: 84%

“…As to whether the data reported on diet-induced weight loss can be extrapolated to bariatric surgery-induced weight loss is a more challenging question. Indeed, several studies recently reported bariatric surgery-induced BAT activation and WAT browning in the neck region (Neinast et al, 2015;Oliveira et al, 2016;Rachid et al, 2015;Vijgen et al, 2012). Beyond the aforementioned hypothetical opposite response to CR of distinct WAT depots, these apparently contradictory findings may be accounted for by the Data are mean ± SEM.…”

Section: Relevance and Limitations Of Studying Subcutaneous Abdominalmentioning

confidence: 99%

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Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity

et al. 2018

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Caloric restriction (CR) is standard lifestyle therapy in obesity management. CR-induced weight loss improves the metabolic profile of individuals with obesity. In mice, occurrence of beige fat cells in white fat depots favors a metabolically healthy phenotype, and CR promotes browning of white adipose tissue (WAT). Here, human subcutaneous abdominal WAT samples were analyzed in 289 individuals with obesity following a two-phase dietary intervention consisting of an 8 week very low calorie diet and a 6-month weight-maintenance phase. Before the intervention, we show sex differences and seasonal variation, with higher expression of brown and beige markers in women with obesity and during winter, respectively. The very low calorie diet resulted in decreased browning of subcutaneous abdominal WAT. During the whole dietary intervention, evolution of body fat and insulin resistance was independent of changes in brown and beige fat markers. These data suggest that diet-induced effects on body fat and insulin resistance are independent of subcutaneous abdominal WAT browning in people with obesity.

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Section: Gene Expression Of Brown and Beige Markers In Subcutaneous Asupporting

confidence: 84%

Section: Relevance and Limitations Of Studying Subcutaneous Abdominalmentioning

confidence: 99%

Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity

et al. 2018

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“…In addition, recent findings show that Roux-en-Y gastric bypass (RYGB) surgery leads to browning of gonadal WAT in female mice and this may be explained in part by the upregulation of ANP and BNP after RYGB (Neinast et al, 2015). Similar observations have been reported in humans undergoing RYGB surgery, although detailed mechanisms by which RYGB surgery promotes beige adipocyte biogenesis in supraclavicular adipose tissue are still unknown (Rachid et al, 2015). …”

Section: Heartsupporting

confidence: 75%

Inter-organ regulation of adipose tissue browning

Wang

Yang

2016

Cell. Mol. Life Sci.

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Adaptive thermogenesis is an important component of energy expenditure. Brown adipocytes are best known for their ability to convert chemical energy into heat. Beige cells are brown-like adipocytes that arise in white adipose tissue in response to certain environmental cues to dissipate heat and improve metabolic homeostasis. A large body of intrinsic factors and external signals are critical for the function of beige adipocytes. In this review, we discuss recent advances in our understanding of neuronal, hormonal, and metabolic regulation of the development and activation of beige adipocytes, with a focus on the regulation of beige adipocytes by other organs, tissues, and cells. Understanding the cellular and molecular mechanisms of inter-organ regulation of adipose tissue browning may provide an avenue for combating obesity and associated diseases.

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“…Similarly, body weight reduction by the Roux-en-Y gastric bypass (RYGB) was associated with an increase in BAT activity under cold. This increase in BAT activity levels appears to be independent of hypothalamic activity (Rachid et al, 2015). In mice, higher expression of UCP1 was observed in the gonadal WAT but not in the inguinal WAT after RYGB surgery.…”

Section: Human Batmentioning

confidence: 99%

Brown and Beige Fat: Physiological Roles beyond Heat Generation

2015

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Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered attention as a therapeutic intervention for obesity and metabolic diseases including type2 diabetes. As we better understand the physiological roles of classical brown and beige adipocytes, it is becoming clear that BAT is not simply a heat-generating organ. Increased beige fat mass in response to a variety of external/internal cues is associated with significant improvements in glucose and lipid homeostasis that may not be entirely mediated by UCP1. We aim to discuss recent insights regarding the developmental lineages, molecular regulation, and new functions for brown and beige adipocytes.

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Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity

Abstract: In humans, the increase in brown/beige adipose tissue activity related to body mass reduction occurs independently of changes in hypothalamic activity as determined by functional magnetic resonance.

Cited by 45 publications

References 46 publications

Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity

Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity

Inter-organ regulation of adipose tissue browning

Brown and Beige Fat: Physiological Roles beyond Heat Generation

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