Distinct prognostic values of mRNA expression of glutathione peroxidases in non–small cell lung cancer

Abstract

IntroductionGlutathione peroxidases (GPxs) constitutes an enzyme family which has the ability to reduce free hydrogen peroxide to water and lipid hydroperoxides to their corresponding alcohols, and its main biological roles are to protect organisms from oxidative stress-induced damage. GPxs include eight members in different tissues of the body, and they play essential roles in carcinogenesis. However, the prognostic value of individual GPx in non-small cell lung cancer (NSCLC) remains elusive.Materials and methodsIn the current study, we investigated the prognostic value of GPxs in NSCLC patients through the “Kaplan–Meier plotter” database, wherein updated gene expression data and survival information from a total of 1,926 NSCLC patients are included.ResultsHigh expression of GPx1 mRNA was correlated with worse overall survival (OS) in adenocarcinoma patients. High expression of GPx2 mRNA was correlated with worse OS for all NSCLC patients. In contrast, high expression of GPx3 mRNA was associated with better OS for all NSCLC patients. High expression of GPx4 mRNA was significantly correlated with worsening adenocarcinoma in these patients. GPx5 mRNA high expression correlated with worsening OS for all NSCLC patients.DiscussionThe current findings of prognostic values of individual mRNA expression of GPxs in NSCLC patients indicate some GPxs may have prognostic value in NSCLC patients, and this needs further study.

LncRNA VPS9D1-AS1 promotes cell proliferation in acute lymphoblastic leukemia through modulating GPX1 expression by miR-491-5p and miR-214-3p evasion

“…Previous researches have reported the oncogenic role of GPX1 in several carcinomas. For example, Liu et al demonstrated that glutathione peroxidases have distinct prognostic values for non-small cell lung carcinoma [ 24 ]. Chen et al indicated that GPX1 promotes NSCLC cisplatin-resistance via ROS-induced PI3K/AKT pathway [ 25 ].…”

The Effect of Glutathione Peroxidase-1 Knockout on Anticancer Drug Sensitivities and Reactive Oxygen Species in Haploid HAP-1 Cells

“…It is known that in some types of cancer GPx1 is upregulated, e.g., adult acute leukemia, thyroid tumors or urothelial carcinoma, whereas other types showing a downregulation such as adult chronic leukemia, breast cancer cell lines, gliomas or renal cell carcinoma [ 14 , 15 , 16 , 17 , 18 , 19 ]. Furthermore, it has also been reported that especially the upregulation of GPx in cancer tissues results in poor prognosis in tumor diseases such as kidney cancer, large cell and non-small cell lung carcinoma, squamous cell carcinoma or prostate cancer [ 20 , 21 , 22 , 23 , 24 ].…”

Distinct expression pattern and prognostic values of pituitary tumor transforming gene family genes in non‑small cell lung cancer

“…Lung cancer is the leading cause of cancer-associated mortality worldwide in men and women, and its prognosis remains dismal with a five-year survival rate of <15% (1). Non-small cell lung cancer (NSCLC), including lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), accounts for ~75–80% of all lung cancer cases (2). In addition, although there are several treatment methods for patients with early-stage NSCLC, including surgery, chemotherapy, radiotherapy and molecular targeted therapy, the number of NSCLC cases is still increasing.…”