Distinct prognostic roles of S100 mRNA expression in gastric cancer

Wang, Chen; Luo, Jing; Rong, Jialing; He, Siying; Zhang, Lei; Zheng, Fang

doi:10.1016/j.prp.2018.10.034

Cited by 21 publications

(13 citation statements)

References 68 publications

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“…All S100 proteins have a certain degree of sequence and structural similarity, but each protein is encoded by a specific gene that has distinct differences in protein-expressing cells and biological functions (7,8). Some members of the S100 protein family play an important role in the pathophysiology of certain cancer types (2,(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

S100 Proteins in Pancreatic Cancer: Current Knowledge and Future Perspectives

Zhou

Guo

et al. 2021

Front. Oncol.

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Pancreatic cancer (PC) is a highly malignant tumor occurring in the digestive system. Currently, there is a lack of specific and effective interventions for PC; thus, further exploration regarding the pathogenesis of this malignancy is warranted. The S100 protein family, a collection of calcium-binding proteins expressed only in vertebrates, comprises 25 members with high sequence and structural similarity. Dysregulated expression of S100 proteins is a biomarker of cancer progression and prognosis. Functionally, these proteins are associated with the regulation of multiple cellular processes, including proliferation, apoptosis, growth, differentiation, enzyme activation, migration/invasion, Ca2+ homeostasis, and energy metabolism. This review highlights the significance of the S100 family in the diagnosis and prognosis of PC and its vital functions in tumor cell metastasis, invasion and proliferation. A further understanding of S100 proteins will provide potential therapeutic targets for preventing or treating PC.

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Section: Introductionmentioning

confidence: 99%

S100 Proteins in Pancreatic Cancer: Current Knowledge and Future Perspectives

Zhou

Guo

et al. 2021

Front. Oncol.

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“…S100A3 plays a vital role in some cancers, for instance, ovarian cancer, gastric cancer and colorectal Cancer 8,30,31 . But the role of S100A3 in PAAD patients has not been investigated.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Prognosis of S100 Family Members and Their Relationship with Tumor-Infiltrating Immune Cells in Human Pancreatic Adenocarcinoma

Ren

Chen

Zhang

et al. 2022

Preprint

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Background: S100 family members(S100s) are small molecular EF hand calcium binding proteins and widely expressed in many tissues and organs. S100s are shown to be biomarkers of disease progression and prognosis in various types of cancers. Nevertheless, the expression patterns, function, prognostic values of S100s and its association with tumor-infiltrating immune cells in Pancreatic Adenocarcinoma(PAAD) patients have not been systematically clarified. Methods: we explored that the expression and roles of the entire twenty S100s in PAAD patients by using the following public databases: Oncomine, GEPIA, cBioPortal, Metascape, STRING, TIMER and GeneMANIA.Results: The S100A2/A3/A4/A6/A8/A9/A10/A11/A13/A14/A16/B/P mRNA expression were significantly upregulated in PAAD patients. The mRNA expression of S100A3/A4/A5/A6/A10/A11/A14/A16/Z were significantly negatively related with the tumor stage in PAAD patients. We found that the S100A2/A3/A5/A10/A11/A14/A16 were significantly correlated with poor OS, whereas the increased levels of S100A1/B/G/Z were strongly associated with good OS. We found significant correlations among S100s and Tumor-Infiltrating Immune Cells. Cox proportional risk models revealed that B cells, Dendritic cells and S100A1/A5/A6/A8/A9/A13/A14 were significantly related with outcomes in PAAD patients. Conclusions: S100A2/A3/A10/A11/A14/A16 may serve as new diagnostic and prognostic biomarkers for PAAD patients and provide new clues for immunotherapy in PAAD patients.

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“…Among these genes, S100A3 belongs to the S100 family and is considered to be associated with a good prognosis of ovarian cancer ( Bai et al, 2018 ), which is similar to our results. However, in gastric cancer, the high expression of S100A3 is closely in relation to the poor survival of patients ( Wang et al, 2019 ). STC2 (stanniocalcin 2), whose expression in ESCA was higher than that in corresponding normal tissues, was significantly associated with lymph node metastasis, lymphatic invasion and distant metastasis ( Kita et al, 2011 ; Kashyap et al, 2012 ), and has been reported as a prognostic glycolysis-related gene in HNSCC ( Ferreira do Carmo et al, 2020 ; Liu and Yin, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Esophageal Cancer Associated Immune Genes as Biomarkers for Predicting Outcome in Upper Gastrointestinal Tumors

Zhu

Xia

et al. 2021

Front. Genet.

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Esophageal cancer (EC) is the seventh most common tumor in the world, ranking the sixth leading cause of cancer death, with a 5-year survival rate of 15-25%. Therefore, reliable prognostic biomarkers are needed to effectively predict the prognosis of EC. In this study, the gene profile information of the EC cohort served as a training set, which was derived from TCGA and Immport databases. GO and KEGG enrichment analysis was performed on the differential genes in normal and tumor groups of EC. The immune genes in differentially expressed genes (DEGs) were further obtained for univariate and multivariate Cox and Lasso regression analysis, and 6 independent immune genes (S100A3, STC2, HSPA6, CCL25, GPER1, and OSM) associated with prognosis were obtained to establish an immune risk score signature (IRSS). The signature was validated using head and neck cancers (HNSC) and gastric cancer (GC)in upper gastrointestinal malignancies as validation sets. The Kaplan-Meier results showed that the prognosis of the high-risk group was significantly favorable than that of the low-risk group in both the training set (P < 0.001; HR = 3.68, 95% CI = 2.14−6.35) and the validation set (P = 0.010; HR = 1.43, 95% CI = 1.09−1.88). A nomogram combining multiple clinical information and IRSS was more effective than a single independent prognostic factor in predicting outcome. This study explored the potential link between immunity and EC, and established and validated prognostic biomarkers that can effectively predict the prognosis of EC, HNSC and GC based on six immune genes.

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Distinct prognostic roles of S100 mRNA expression in gastric cancer

Cited by 21 publications

References 68 publications

S100 Proteins in Pancreatic Cancer: Current Knowledge and Future Perspectives

S100 Proteins in Pancreatic Cancer: Current Knowledge and Future Perspectives

Comprehensive Analysis of the Prognosis of S100 Family Members and Their Relationship with Tumor-Infiltrating Immune Cells in Human Pancreatic Adenocarcinoma

Esophageal Cancer Associated Immune Genes as Biomarkers for Predicting Outcome in Upper Gastrointestinal Tumors

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