Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants

Wouters, Hans; Rhebergen, Didi; Vervloet, Marcia; Egberts, Toine C. G.; Taxis, Katja; Dijk, Liset van; Gardarsdóttir, Helga

doi:10.1007/s40265-019-01107-y

Cited by 7 publications

(4 citation statements)

References 28 publications

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“…A study done as UK Defeat Depression Campaign indicated that the effective antidepressant drug therapy, the treatment duration should not be less than four consecutive months, but in their study, they found only 31% of patients adherence to the fourth month (SSRIs: fluoxetine: 31%; paroxetine: 30%; sertraline: 24%) 25,29 . This study showed that the higher rate of adherence (17%) is in males with the P-value of 0.324, and it was also observed that patients who were never married had a higher percentage of adherence (18%).…”

Section: Discussionmentioning

confidence: 99%

Assessing the beliefs about antidepressant medication and adherence to therapy in patients with major depressive disorders

Khan

Naqvi

Rizwan

et al. 2021

Ann. psychophysiol.

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Background: Patients on antidepressant therapy have no contact with their physicians until their next appointment, which in most cases could be more than two weeks apart. This crucial time is of utmost importance as this could assess the patient's will to follow the prescribed therapy and the general belief about the benefits of using antidepressant treatment. Thus medication adherence is necessary to reduce the risk of suicidal tendencies and mortality in these patients. The study aimed to evaluate medication adherence and adherence to antidepressant therapy in patients with major depressive disorder. Methodology: in this cross-sectional study, a total of 101 clinically diagnosed patients with Major Depressive Disorder (MDD) were included in the study from psychiatric and medical OPD from June 2018 to June 2019, from Jinnah Medical College Hospital (JMCH). Belief about medicines questionnaire (BMQ specific and BMQ general), regarding their views about the prescribed medication and the modified questionnaire of the medication adherence scale used, scores were calculated to give a numerical value to measure the adherence to antidepressant medication. Results: According to the study, 101 patients with major depressive disorder had an overall good belief about medication but have low adherence. Belief about medicines questionnaire (based on BMQ) BMQ- the specific q1-10 score was 36.54 (necessity, concern), BMQ-general 27.98 score, q11-18 (overuse and harm). Regarding their views about the prescribed medication. 86% of participants with the major depressive disorder had low adherence (scores 0-5), and those with high adherence were only 14% (scores 6-8). The patients diagnosed with the major depressive disorder who had co-morbid (diabetes, hypertension, hypothyroidism, etc.) had better adherence for their prescribed treatment as compared to those without co-morbid. Conclusion: This study indicates that although patients with major depressive disorder from tertiary care hospitals in Karachi had a positive belief about medication but have low adherence to antidepressant therapy.

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Section: Discussionmentioning

confidence: 99%

Assessing the beliefs about antidepressant medication and adherence to therapy in patients with major depressive disorders

Khan

Naqvi

Rizwan

et al. 2021

Ann. psychophysiol.

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“…Digital health interventions are interventions delivered through digital technologies such as text messages, phone calls, websites, and apps. Previous studies ( 28 , 29 ) have shown that results between subjective and objective measures of adherence are not always consistent, and the study by Cross et al ( 14 ) categorized adherence measures into subjective and objective measures. Therefore, the primary outcomes assessed adherence to oral iron supplementation (with objective and/or subjective measure) and tablets consumption.…”

Section: Methodsmentioning

confidence: 99%

Digital versus non-digital health interventions to improve iron supplementation in pregnant women: a systematic review and meta-analysis

Shao,

Meng,

Liang

2024

Front. Med.

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ObjectiveTo investigate the effects of digital health interventions for improving adherence to oral iron supplementation in pregnant women.Literature searchFive databases were searched from their inception to October 2023 with no date restrictions.Study selectionRandomized controlled trials (RCTs) that assessed the effects of digital health interventions on adherence to oral iron supplementation (e.g., tablets and capsules) compared to non-digital health interventions for pregnant women were eligible.Data synthesisWe calculated standardized mean differences (SMDs) and mean differences (MDs) with 95% confidence intervals (CIs) for continuous variables using the inverse variance method. We calculated odds ratios (OR) with 95%CI for categorical variables using the Mantel–Haenszel model. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. The risk of bias of the included RCTs was assessed using the Cochrane risk of bias tool 2.0.ResultsTen trials with 1,633 participants were included. Based on 7 trials, digital health interventions can improve objective adherence rate comparing with non-digital health interventions (1,289 participants, OR = 4.07 [2.19, 7.57], p < 0.001, I2 = 69%) in pregnant women. Digital health interventions can improve subjective adherence behavior comparing with non-digital health interventions (3 trials, 434 participants, SMD = 0.82 [0.62, 1.01], p < 0.001, I2 = 0%) in pregnant women. Based on 3 trials, digital health interventions can improve tablets consumption comparing with non-digital health interventions (333 participants, SMD = 1.00 [0.57, 1.42], p < 0.001, I2 = 66%) in pregnant women. Digital health interventions can improve hemoglobin level comparing with non-digital health interventions (7 trials, 1,216 participants, MD = 0.59 [0.31, 0.88], p < 0.001, I2 = 93%) in pregnant women.ConclusionDigital health interventions were effective at improving adherence to oral iron supplementation and hemoglobin levels in pregnant women.

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“…24 To provide the most informed patient care, providers should ideally verify medication adherence with objective measures. 25 Accurate medication adherence data can support providers when making clinical decisions (eg, treatment modification for patients whose symptoms are not well controlled) 20,26 and help identify individuals who need additional support with adherence. 27 Several advances in technology and medication formulations have emerged to improve the accuracy of determining medication adherence.…”

Section: Introductionmentioning

confidence: 99%

Real-World Evidence of Aripiprazole Tablets with Sensor: Treatment Patterns and Impacts on Psychiatric Healthcare Resource Utilization

Boskovic¹,

Liang²,

Parab³

et al. 2023

CEOR

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Purpose Maintaining adherence to antipsychotic (AP) medication is often challenging. Aripiprazole tablets with sensor (AS) contain an ingestible event marker and communicate with wearable patches and a smartphone app to provide objective medication ingestion data. This study evaluated real-world treatment patterns of AS usage and its impact on psychiatric healthcare resource utilization (HCRU). Patients and Methods This retrospective, observational cohort study identified individuals who initiated AS between 1/1/2019 and 6/30/2020 with 3 months baseline and 6 months of follow-up data using a commercial medical and pharmacy claims database (Clarivate). Controls were propensity score-matched (4:1) to AS initiators based on age (±2 years), sex, diagnosis (major depressive disorder [MDD], schizophrenia, bipolar I disorder [BP-I], other), insurance, and baseline oral AP use (yes/no). Days of AP supply were evaluated using a general regression model. The frequency of psychiatric HCRU during follow-up was compared between groups using a zero-inflated regression model. Results Most AS initiators were diagnosed with MDD (61.2%) and were women (61.2%); mean age was 37.7 years (standard deviation: 14.1). Most AS initiators (53.1%) continued treatment for >60 days (mean days of supply = 77). After adjusting for covariates, AS initiators had 41% more days of AP supply during follow-up compared with controls ( P <0.0001) and significantly lower adjusted odds ratios (ORs) for psychiatric outpatient visits (adjusted OR = 0.80; P <0.05), emergency department visits (adjusted OR = 0.11; P <0.05), inpatient visits (adjusted OR = 0.42; P <0.05), and other medical services (adjusted OR = 0.25; P <0.05). Conclusion Participants who implemented AS had significantly more days of AP supply and fewer psychiatric care visits. These preliminary results suggest AS usage can help build regular medication-taking habits and holds promise for reducing psychiatric HCRU. Additional studies with larger sample sizes are warranted to inform clinical practice and coverage decisions.

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Distinct Profiles on Subjective and Objective Adherence Measures in Patients Prescribed Antidepressants

Cited by 7 publications

References 28 publications

Assessing the beliefs about antidepressant medication and adherence to therapy in patients with major depressive disorders

Assessing the beliefs about antidepressant medication and adherence to therapy in patients with major depressive disorders

Digital versus non-digital health interventions to improve iron supplementation in pregnant women: a systematic review and meta-analysis

Real-World Evidence of Aripiprazole Tablets with Sensor: Treatment Patterns and Impacts on Psychiatric Healthcare Resource Utilization

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