Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis

Suzuki, Yuzo; Yoshimura, Katsuhiro; Enomoto, Yasunori; Yasui, Hideki; Hozumi, Hironao; Karayama, Masato; Furuhashi, Kazuki; Enomoto, Noriyuki; Fujisawa, Tomoyuki; Nakamura, Yutaro; Inui, Naoki; Suda, Takafumi

doi:10.1038/s41598-018-32478-z

Cited by 80 publications

(83 citation statements)

References 34 publications

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“…Evaluation of the nutrition status with BMI was essential in prognosis of other pulmonary disease patients including the chronic obstructive pulmonary disease and the nosocomial infection. (26)(27)(28)(29) The present study suggested that the gender of females might be risk for the prolonged hospitalization. The reason why the hospitalization stay tended to be long in the aged females pneumonia patients was not clear, (30) as the number of the patients with good performance status (0 + 1) was not different between males (14 cases) and females (13 cases) and there was no significance difference between the genders regarding the other factors evaluated in the present study.…”

Section: Discussionmentioning

confidence: 53%

Risk for prolonged hospitalization and mortality in aged community acquired pneumonia patients: a retrospective study in Japan

Matsuo

Takamori

Kawaura

et al. 2020

J. Clin. Biochem. Nutr.

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The present study aimed to reveal; i) risk for prolonged hospital ization and mortality in aged community acquired pneumonia patients, and ii) whether swallowing ability was related to re hospitalization. The present retrospective study included 92 patients older than 75 years hospitalized with community acquired pneumonia in Takagi hospital between April 2017 and March 2018. The patients were classified into 3 groups; discharged within 17 days (group I): hospitalized more than 18 days (group II): died during the hospitalization (group III). Swallowing ability was evaluated if available. Univariate analysis indicated males and body mass index (BMI) in group I (n = 24) were higher than group II (n = 46). Group III (n = 22) had low serum albumin, low BMI, and severe disease progression compared with group I. Multivariate analysis demonstrated that group II BMI was lower than group I [odds ratio (OR) = 1.18, p = 0.042]. Group III had lower serum albumin level compared with group I (OR = 81.01, p = 0.025). Diabetes mellitus (p = 0.009), but not swallowing disability, was risk for readmission. Malnutrition represented by low albumin enhanced mortality rate in the pneumonia patients, and low BMI and diabetes mellitus might increase the pneumonia risk.

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Section: Discussionmentioning

confidence: 53%

Risk for prolonged hospitalization and mortality in aged community acquired pneumonia patients: a retrospective study in Japan

Matsuo

Takamori

Kawaura

et al. 2020

J. Clin. Biochem. Nutr.

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“…The compound deposition/release rate in adipose tissue depends on tissue volume [ 29 , 30 ]. Loss of adipose and muscle tissue is often observed in cancer, COPD, pulmonary fibrosis, and cachexia [ 31 ]. These changes in body composition can lead to increased release of deposited compounds and, in our case, of toluene, ethylbenzene, and styrene.…”

Section: Discussionmentioning

confidence: 99%

Target Analysis of Volatile Organic Compounds in Exhaled Breath for Lung Cancer Discrimination from Other Pulmonary Diseases and Healthy Persons

et al. 2020

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The aim of the present study was to investigate the ability of breath analysis to distinguish lung cancer (LC) patients from patients with other respiratory diseases and healthy people. The population sample consisted of 51 patients with confirmed LC, 38 patients with pathological computed tomography (CT) findings not diagnosed with LC, and 53 healthy controls. The concentrations of 19 volatile organic compounds (VOCs) were quantified in the exhaled breath of study participants by solid phase microextraction (SPME) of the VOCs and subsequent gas chromatography-mass spectrometry (GC-MS) analysis. Kruskal–Wallis and Mann–Whitney tests were used to identify significant differences between subgroups. Machine learning methods were used to determine the discriminant power of the method. Several compounds were found to differ significantly between LC patients and healthy controls. Strong associations were identified for 2-propanol, 1-propanol, toluene, ethylbenzene, and styrene (p-values < 0.001–0.006). These associations remained significant when ambient air concentrations were subtracted from breath concentrations. VOC levels were found to be affected by ambient air concentrations and a few by smoking status. The random forest machine learning algorithm achieved a correct classification of patients of 88.5% (area under the curve—AUC 0.94). However, none of the methods used achieved adequate discrimination between LC patients and patients with abnormal computed tomography (CT) findings. Biomarker sets, consisting mainly of the exogenous monoaromatic compounds and 1- and 2- propanol, adequately discriminated LC patients from healthy controls. The breath concentrations of these compounds may reflect the alterations in patient’s physiological and biochemical status and perhaps can be used as probes for the investigation of these statuses or normalization of patient-related factors in breath analysis.

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“…Baseline ESM CSA is a prognostic factor in patients with IPF 22,24 . Here, we demonstrated that the serial change in ESM CSA is also a prognostic factor in patients with IPF.…”

Section: Discussionmentioning

confidence: 99%

“…Miller et al reported that height-adjusted ESM CSA was significantly associated with 30-day mortality and length of hospital stay after lobectomy in patients with lung cancer 23 . Suzuki et al also revealed that a smaller ESM CSA in patients with IPF was associated with a poor prognosis 22 .…”

mentioning

confidence: 98%

Early decrease in erector spinae muscle area and future risk of mortality in idiopathic pulmonary fibrosis

Nakano

Ohkubo

Taniguchi

et al. 2020

Sci Rep

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computed tomography (ct) assessment of the cross-sectional area of the erector spinae muscles (eSM cSA ) can be used to evaluate sarcopenia and cachexia in patients with lung diseases. This study aimed to confirm whether serial changes in ESM cSA are associated with survival in patients with idiopathic pulmonary fibrosis (IPF). Data from consecutive patients with IPF who were referred to a single centre were retrospectively reviewed. We measured the ESM cSA at the level of the 12th thoracic vertebra on CT images at referral and 6 months later (n = 119). The follow-up time was from 817-1633 days (median, 1335 days) and 59 patients (49.6%) died. A univariate Cox regression analysis showed that the decline in % predicted forced vital capacity (FVC) (Hazard ratios [HR] 1.041, 95% confidence interval [CI] 1.013-1.069, P = 0.004), the decline in body mass index (BMI) (HR 1.084, 95% CI 1.037-1.128; P < 0.001) and that in ESM cSA (HR 1.057, 95% CI 1.027-1.086; P < 0.001) were prognostic factors. For multivariate analyses, the decline in ESM cSA (HR 1.039, 95% CI 1.007-1.071, P = 0.015) was a significant prognostic factor, while those in % FVC and BMI were discarded. Early decrease in ESM cSA may be a useful predictor of prognosis in patients with IPF.

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Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis

Cited by 80 publications

References 34 publications

Risk for prolonged hospitalization and mortality in aged community acquired pneumonia patients: a retrospective study in Japan

Risk for prolonged hospitalization and mortality in aged community acquired pneumonia patients: a retrospective study in Japan

Target Analysis of Volatile Organic Compounds in Exhaled Breath for Lung Cancer Discrimination from Other Pulmonary Diseases and Healthy Persons

Early decrease in erector spinae muscle area and future risk of mortality in idiopathic pulmonary fibrosis

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