Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition

Rogers, Robert D.; Ramnani, Narender; Mackay, Clare E.; Wilson, James L.; Jezzard, Peter; Carter, Cameron S.; Smith, Stephen M.

doi:10.1016/j.biopsych.2003.11.012

Cited by 373 publications

(284 citation statements)

References 70 publications

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“…Neuropsychological, lesion, and functional neuroimaging studies in humans have identified the OFC/VLPFC (Arana et al, 2003;Elliott et al, 1999;Ernst et al, 2002;Paulus et al, 2001;Rogers et al, 1999;Walton et al, 2004;Rushworth, Buckley, Gough, Alexander, Kyriazis, McDonald, Passingham, 2005;Elliott, Rees, Dolan, 1999) and ACC (Bush et al, 2002;Ernst et al, 2004;Rogers et al, 2004;Walton et al, 2004;Williams et al, 2004) as key neural substrates of decision-making processes. Often modulated by both risk (Critchley et al, 2001;Cohen et al, 2005) and reward (Rogers et al, 2004), these structures are purported to support specific functions that are specialized by subregions (e.g., lateral vs. medial OFC, dorsal vs. ventral ACC).…”

Section: Discussionmentioning

confidence: 99%

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Neural substrates of choice selection in adults and adolescents: Development of the ventrolateral prefrontal and anterior cingulate cortices

et al. 2007

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A heightened propensity for risk-taking and poor decision-making underlies the peak morbidity and mortality rates reported during adolescence. Delayed maturation of cortical structures during the adolescent years has been proposed as a possible explanation for this observation. Here, we test the hypothesis of adolescent delayed maturation by using fMRI during a monetary decision-making task that directly examines risk-taking behavior during choice selection. Orbitofrontal/ventrolateral prefrontal cortex (OFC/VLPFC) and dorsal anterior cingulate cortex (ACC) were examined selectively since both have been implicated in reward-related processes, cognitive control, and resolution of conflicting decisions. Group comparisons revealed greater activation in the OFC/ VLPFC (BA 47) and dorsal ACC (BA 32) in adults than adolescents when making risky selections. Furthermore, reduced activity in these areas correlated with greater risk-taking performance in adolescents and in the combined group. Consistent with predictions, these results suggest that adolescents engage prefrontal regulatory structures to a lesser extent than adults when making risky economic choices.

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Section: Discussionmentioning

confidence: 99%

“…Often modulated by both risk (Critchley et al, 2001;Cohen et al, 2005) and reward (Rogers et al, 2004), these structures are purported to support specific functions that are specialized by subregions (e.g., lateral vs. medial OFC, dorsal vs. ventral ACC).…”

Section: Discussionmentioning

confidence: 99%

Neural substrates of choice selection in adults and adolescents: Development of the ventrolateral prefrontal and anterior cingulate cortices

et al. 2007

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“…Accumulating evidence suggests that emotional decisionmaking depends upon an interconnected circuitry involving the orbitofrontal and medial PFC (including the rostrocingulate cortex), amygdala, and striatum (Bechara et al, 1996;Rogers et al, 2004b), as well as its modulation by monoaminergic systems. Manipulation of the serotonin, noradrenaline, and dopamine has been found to alter the processing of reinforcement cues, while healthy participants perform the risky choice used in the current study (Rogers et al, 2003(Rogers et al, , 2004aScarna et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naïve Controls

Morgan

Impallomeni

Pirona

et al. 2005

Neuropsychopharmacol

111

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“…Moreover, preclinical and functional neuroimaging studies indicate that different brain regions are implicated in distinct aspects of reward processing. The medial prefrontal cortex, for example, has been found to be critically involved in response to single reward deliveries (e.g., Dillon et al, 2008;Knutson et al, 2003), while dorsal anterior cingulate regions play an important role in integrating reinforcement history over time (e.g., Ernst et al, 2004;Rogers et al, 2004). In a notable study in non-human primates, Kennerley et al (2006) recently showed that dorsal anterior cingulate lesions impaired monkeys' ability to integrate reinforcement history over time, which led to an inability to learn which of two differentially rewarded responses was most advantageous, while sparing the animals' ability to respond to single feedback trials.…”

Section: Introductionmentioning

confidence: 99%

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Pizzagalli

Iosifescu

Hallett

et al. 2008

Journal of Psychiatric Research

652

693

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Objective-Anhedonia, the lack of reactivity to pleasurable stimuli, is a cardinal feature of depression that has received renewed interest as a potential endophenotype of this debilitating disease. The goal of the present study was to test the hypothesis that individuals with major depression are characterized by blunted reward responsiveness, particularly when anhedonic symptoms are prominent.Methods-A probabilistic reward task rooted within signal-detection theory was utilized to objectively assess hedonic capacity in 23 unmedicated subjects meeting DSM-IV criteria for major depressive disorder (MDD) and 25 matched control subjects recruited from the community. Hedonic capacity was defined as reward responsiveness -i.e., the participants' propensity to modulate behavior as a function of reward.Results-Compared to controls, MDD subjects showed significantly reduced reward responsiveness. Trial-by-trial probability analyses revealed that MDD subjects, while responsive to delivery of single rewards, were impaired at integrating reinforcement history over time and expressing a response bias toward a more frequently rewarded cue in the absence of immediate reward. This selective impairment correlated with self-reported anhedonic symptoms, even after considering anxiety symptoms and general distress.Conclusions-These findings indicate that MDD is characterized by an impaired tendency to modulate behavior as a function of prior reinforcements, and provides initial clues about which aspects of hedonic processing might be dysfunctional in depression.

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Distinct portions of anterior cingulate cortex and medial prefrontal cortex are activated by reward processing in separable phases of decision-making cognition

Cited by 373 publications

References 70 publications

Neural substrates of choice selection in adults and adolescents: Development of the ventrolateral prefrontal and anterior cingulate cortices

Neural substrates of choice selection in adults and adolescents: Development of the ventrolateral prefrontal and anterior cingulate cortices

Elevated Impulsivity and Impaired Decision-Making in Abstinent Ecstasy (MDMA) Users Compared to Polydrug and Drug-Naïve Controls

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

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