Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation

Grider, J. R.; Jin, Ji‐Guang

doi:10.1523/jneurosci.14-05-02854.1994

Cited by 104 publications

(90 citation statements)

References 22 publications

(42 reference statements)

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“…Since both "dendritic" and "nondendritic" Dogiel type II neurons project to the mucosa (Song et al, 1994) it seems unlikely that one class is a distension receptor and the other a mucosal receptor. A recent study in the rat colon has provided evidence that reflexes evoked by mucosal stimulation are mediated by intrinsic sensory neurons, whereas reflexes evoked by distension can be blocked by interrupting extrinsic neuronal pathways to the gut (Grider and Jin, 1994). This suggests that, at least in this preparation, distensionevoked reflexes may be mediated by the peripheral axons of extrinsic sensory neurons.…”

Section: Discussionmentioning

confidence: 98%

Long aboral projections of Dogiel type II, AH neurons within the myenteric plexus of the guinea pig small intestine

et al. 1995

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Enteric AH neurons, with multipolar Dogiel type II morphology, project around the circumference of the intestine to myenteric ganglia, the submucosa and mucosa. Using retrograde labeling in vitro, intracellular recording, dye filling and immunohistochemistry, the projections of these neurons along the intestine were studied. When the retrograde tracer, Dil, was applied to the myenteric plexus, labeled nerve cell bodies were located up to 111 mm orally but only 13 mm aborally, demonstrating a marked difference in the lengths of projections up and down the small intestine. Of labeled nerve cell bodies located 2–110 mm orally, 43% had Dogiel type II morphology and of these, 70% were immunoreactive for calbindin, a calcium binding protein exclusive to Dogiel type II neurons. Intracellular filling with neurobiotin revealed several long circumferentially directed nerve fibers and short, filamentous dendrites; thus these were “dendritic” Dogiel type II neurons. This class accounts for approximately 3–4% of all myenteric neurons, and about 10% of all Dogiel type II neurons. Intracellular recordings revealed AH cell characteristics, with long afterhyperpolarizations following their action potentials, pronounced slow excitatory synaptic inputs and a lack of fast excitatory synaptic inputs. Antidromic action potentials could be evoked from the Dil application site in some cells, confirming their aboral projection. This is the first account of a major aboral projection of AH/Dogiel type II neurons and suggests an important role in aborally directed reflexes in the intestine.

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Section: Discussionmentioning

confidence: 98%

Long aboral projections of Dogiel type II, AH neurons within the myenteric plexus of the guinea pig small intestine

et al. 1995

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“…There are two ganglionated plexuses, the myenteric plexus lying between the longitudinal and circular muscle, and the submucosal ganglia lying in the submucosa, between the circular muscle and the epithelium. The myenteric plexus and the submucosal plexus are interconnected for efficient inter-communication to coordinate secretion with mixing, and propulsion of the intestinal contents, and with delivery of oxygen and nutrients to nourish the cells (Grider and Jin, 1994). To understand this complex regulatory mechanism requires knowledge of neural reflexes that are activated by appropriate stimuli.…”

Section: Enteric Nervous Systemmentioning

confidence: 99%

Autonomic nervous system and secretion across the intestinal mucosal surface

Xue

Askwith

Javed

et al. 2007

Autonomic Neuroscience

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Chloride secretion is important because it is the driving force for fluid movement into the intestianl lumen. Flow of accummulated fluid flushes out invading micro-orgnaisms in defense of the host. Chloride secretion is regulated by neurons in the submucosal plexus of the enteric nervous system. Mechanosensitive enterochromaffin cells that release 5-hydroxytryptamine (5-HT)activate intrinsic afferent neurons in the submucosal plexus and initiate chloride secretion. Mechanical stimulation by distention may also triggers reflexes by a direct action on intrinsic afferent neurons. Dysregulation of 5-HT release or altered activity of intrinsic afferents is likely to occur in states of inflammation and other disorders.

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“…Peristaltic reflexes in response to stretch and mucosal stimulation are mediated via both extrinsic and intrinsic neurons of the rat colon. 32 In contrast, both stretch and mucosal reflexes are mediated via intrinsic neurons of the guinea pig colon. 33 It is conceivable, therefore, that pellet-stimulated motor responses are less observed in vitro preparations once extrinsic innervation is disrupted in the rat colon.…”

Section: Discussionmentioning

confidence: 99%

“…22 It is well established that the colonic peristaltic reflex is mediated by the release of 5-HT from enterochromaffin cells. 32 A 5-HT acts 5-HT 4 and 5-HT 3 receptors to activate intramural sensory neurons that release calcitonin gene-related peptide. 42 The presence of fecal pellets triggers the release of 5-HT, which acts via both 5-HT 3 and 5-HT 4 receptors to regulate propulsive activity of the guinea pig colon.…”

Section: Discussionmentioning

confidence: 99%

“…36 However, currently it is well accepted that descending relaxations are regulated via nicotinic receptors, rather than muscarinic receptors. 32,43,44 Mucosal and muscle stimulation initiates peristalsis via ascending contractions and descending relaxations. Ascending contractions are mainly mediated via ACh and substance P, while descending relaxations are mainly mediated via nitric oxide (NO), vasoactive intestinal polypeptide, and pituitary adenylate cyclase-activating peptide.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Autonomic Nerve Regulation of Colonic Peristalsis in Guinea Pigs

Gribovskaja‐Rupp¹,

Babygirija²,

Takahashi³

et al. 2014

J Neurogastroenterol Motil

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Background/AimsColonic peristalsis is mainly regulated via intrinsic neurons in guinea pigs. However, autonomic regulation of colonic motility is poorly understood. We explored a guinea pig model for the study of extrinsic nerve effects on the distal colon. MethodsGuinea pigs were sacrificed, their distal colons isolated, preserving pelvic nerves (PN) and inferior mesenteric ganglia (IMG), and placed in a tissue bath. Fecal pellet propagation was conducted during PN and IMG stimulation at 10 Hz, 0.5 ms and 5 V. Distal colon was connected to a closed circuit system, and colonic motor responses were measured during PN and IMG stimulation. ResultsPN stimulation increased pellet velocity to 24.6 ± 0.7 mm/sec (n = 20), while IMG stimulation decreased it to 2.0 ± 0.2 mm/sec (n = 12), compared to controls (13.0 ± 0.7 mm/sec, P ＜ 0.01). In closed circuit experiments, PN stimulation increased the intraluminal pressure, which was abolished by atropine (10 −6 M) and hexamethonium (10 −4 M). PN stimulation reduced the incidence of non-coordinated contractions induced by NG-nitro-L-arginine methyl ester (L-NAME; 10 −4 M). IMG stimulation attenuated intraluminal pressure increase, which was partially reversed by alpha-2 adrenoceptor antagonist (yohimbine; 10 −6 M). Conclusions

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Distinct populations of sensory neurons mediate the peristaltic reflex elicited by muscle stretch and mucosal stimulation

Cited by 104 publications

References 22 publications

Long aboral projections of Dogiel type II, AH neurons within the myenteric plexus of the guinea pig small intestine

Long aboral projections of Dogiel type II, AH neurons within the myenteric plexus of the guinea pig small intestine

Autonomic nervous system and secretion across the intestinal mucosal surface

Autonomic Nerve Regulation of Colonic Peristalsis in Guinea Pigs

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