Distinct phospholipid and sphingolipid species are linked to altered HDL function in apolipoprotein A-I deficiency

Zakiev, Emile; Rached, Fabiana; Lhomme, Marie; Darabi-Amin, Maryam; Ponnaiah, Maharajah; Becker, Pierre-Hadrien; Thérond, Patrice; Serrano, Carlos; Santos, Raul D.; Chapman, M. John; Orekhov, Alexander N.; Kontush, Anatol

doi:10.1016/j.jacl.2019.02.004

Cited by 17 publications

(11 citation statements)

References 47 publications

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“…The vast majority of studies aimed at studying the HDL lipidome are limited to lipid class analysis, [ 14,35–38 ] while only a few have gone further relating lipid species and LC‐FA combinations to HDL function. [ 16,39 ] Our results indicate that changes in specific LC‐FA combinations and lipid species are determinants of HDL ChE capacity and its resistance to oxidation, as a surrogate of HDL functionality. On the one hand, the changes observed after the intake of VOO and FVOO could promote a beneficial increase in the HDL resistance to oxidation in hypercholesterolemic patients, in particular the changes in SM(FA22:1), TAG(FA18:2), TAG52:3(FA16:0) and TAG52:5(FA18:2).…”

Section: Discussionmentioning

confidence: 87%

Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study

Fernández‐Castillejo

Pedret

Catalán

et al. 2021

Molecular Nutrition Food Res

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Scope The lipidomic analysis of high‐density lipoprotein (HDL) could be useful to identify new biomarkers of HDL function. Methods and results A randomized, controlled, double‐blind, crossover trial (33 hypercholesterolaemic subjects) is performed with a control virgin olive oil (VOO), VOO enriched with its own phenolic compounds (FVOO), or VOO enriched with additional phenolic compounds from thyme (FVOOT) for 3 weeks. HDL lipidomic analyses are performed using the Lipidyzer platform. VOO and FVOO intake increase monounsaturated‐fatty acids (FAs) and decrease saturated and polyunsaturated FAs in triacylglyceride (TAG) species, among others species. In contrast, FVOOT intake does not induce these FAs changes. The decrease in TAG52:3(FA16:0) after VOO intake and the decrease in TAG52:5(FA18:2) after FVOO intake are inversely associated with changes in HDL resistance to oxidation. After FVOO intake, the decrease in TAG54:6(FA18:2) in HDL is inversely associated with changes in HDL cholesterol efflux capacity. Conclusion VOO and FVOO consumption has an impact on the HDL lipidome, in particular TAG species. Although TAGs are minor components of HDL mass, the observed changes in TAG modulated HDL functionality towards a cardioprotective mode. The assessment of the HDL lipidome is a valuable approach to identify and characterize new biomarkers of HDL function.

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Section: Discussionmentioning

confidence: 87%

Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study

Fernández‐Castillejo

Pedret

Catalán

et al. 2021

Molecular Nutrition Food Res

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“…The literature shows that the metabolism of HDL involves a complex network of factors that regulate their synthesis, intravascular remodeling, and catabolism; their components in lipids and apoproteins assembled after their secretion (through liver and intestine) are frequently interchanged or transferred to other lipoproteins, giving way to a family of HDL subfractions with similar components (lipids, proteins), but not in the same amount and composition and, hence, do not seem to have the same properties [ 21 , [27] , [28] , [29] ]. Among the protein components of the HDL subpopulations, there are the APOA (its principal apoprotein) and the PON1.…”

Section: Discussionmentioning

confidence: 99%

Arylesterase activity of paraoxonase 1 (PON1) on HDL3 and HDL2: Relationship with Q192R, C-108T, and L55M polymorphisms

et al. 2021

Biochemistry and Biophysics Reports

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Background Controversy exists regarding the role of the subfractions of high-density lipoproteins (HDL 2 and HDL 3 ) in cardiovascular disease. The functionality of these particles, and their protective role, is due in part to the paraoxonase 1 (PON1) presence in them. The polymorphisms rs662 (Q192R, A/G), rs854560 (L55 M, T/A), and rs705379 (C-108T) of the PON1 gene have been related to enzyme activity and, with the anti-oxidative capacity of the HDL. The objective was to determine the arylesterase PON1 activity in HDL 3 and HDL 2 and its relationship with the polymorphisms mentioned, in a young population. Methods The polymorphisms were determined through mini-sequencing (SnaPshot). The HDL subpopulations were separated via ionic precipitation, cholesterol was measured with enzymatic methods, and PON1 activity was measured through spectrophotometry. Results The results show that the PON1 polymorphisms do not influence the cholesterol in the HDL. A variation between 40.02 and 43.9 mg/dL was in all the polymorphisms without significant differences. Additionally, PON1 activity in the HDL 3 subfractions was greater (62.83 ± 20 kU/L) than with HDL 2 (35.8 ± 20.8 kU/L) in the whole population and in all the polymorphisms (p < 0.001), and it was independent of the polymorphism and differential arylesterase activity in the Q192R polymorphism (QQ > QR > RR). Thus, 115.90 ± 30.7, 88.78 ± 21.3, 65.29 ± 10.2, respectively, for total HDL, with identical behavior for HDL 3 and HDL 2 . Conclusions PON1 polymorphisms do not influence the HDL -c , and the PON activity is greater in the HDL 3 than in the HDL 2 , independent of the polymorphism, but it is necessary to delve into the functionality of these findings in different populations.

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“…124 HDL lipidomic changes associated with proinflammatory HDL and impaired cholesterol efflux include increased concentrations of ceramides (up to 3-fold) and decreased phosphatidylethanolamine (up to 5-fold). 125 Plasmalogens appear to have an important role in attenuating inflammation from at least 2 forms of cell death, ferroptosis and neutrophil extracellular traps (NETs). Ferroptosis is a regulated necrosis triggered by iron toxicity and intracellular phospholipid peroxidation normally kept in check by cellular antioxidant systems.…”

Section: Phospholipidsmentioning

confidence: 99%

Next Generation, Modifiable Cardiometabolic Biomarkers: Mitochondrial Adaptation and Metabolic Resilience: A Scientific Statement From the American Heart Association

Mietus-Snyder,

Perak,

Cheng

et al. 2023

Circulation

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Cardiometabolic risk is increasing in prevalence across the life span with disproportionate ramifications for youth at socioeconomic disadvantage. Established risk factors and associated disease progression are harder to reverse as they become entrenched over time; if current trends are unchecked, the consequences for individual and societal wellness will become untenable. Interrelated root causes of ectopic adiposity and insulin resistance are understood but identified late in the trajectory of systemic metabolic dysregulation when traditional cardiometabolic risk factors cross current diagnostic thresholds of disease. Thus, children at cardiometabolic risk are often exposed to suboptimal metabolism over years before they present with clinical symptoms, at which point life-long reliance on pharmacotherapy may only mitigate but not reverse the risk. Leading-edge indicators are needed to detect the earliest departure from healthy metabolism, so that targeted, primordial, and primary prevention of cardiometabolic risk is possible. Better understanding of biomarkers that reflect the earliest transitions to dysmetabolism, beginning in utero, ideally biomarkers that are also mechanistic/causal and modifiable, is critically needed. This scientific statement explores emerging biomarkers of cardiometabolic risk across rapidly evolving and interrelated “omic” fields of research (the epigenome, microbiome, metabolome, lipidome, and inflammasome). Connections in each domain to mitochondrial function are identified that may mediate the favorable responses of each of the omic biomarkers featured to a heart-healthy lifestyle, notably to nutritional interventions. Fuller implementation of evidence-based nutrition must address environmental and socioeconomic disparities that can either facilitate or impede response to therapy.

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Distinct phospholipid and sphingolipid species are linked to altered HDL function in apolipoprotein A-I deficiency

Cited by 17 publications

References 47 publications

Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study

Virgin Olive Oil Phenolic Compounds Modulate the HDL Lipidome in Hypercholesterolaemic Subjects: A Lipidomic Analysis of the VOHF Study

Arylesterase activity of paraoxonase 1 (PON1) on HDL3 and HDL2: Relationship with Q192R, C-108T, and L55M polymorphisms

Next Generation, Modifiable Cardiometabolic Biomarkers: Mitochondrial Adaptation and Metabolic Resilience: A Scientific Statement From the American Heart Association

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