Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Turner, Nigel; Kowalski, Greg M.; Leslie, Simon J; Risis, Steve; Yang, Christine; Lee, Robert S.; Babb, Joanne R; Meikle, Peter J.; Lancaster, Graeme I.; Henstridge, Darren C.; White, Phillip J.; Kraegen, Edward W.; Marette, André; Cooney, Gregory J.; Febbraio, Mark A.; Bruce, Clinton R.

doi:10.1007/s00125-013-2913-1

Cited by 345 publications

(357 citation statements)

References 48 publications

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“…The finding of similar body weight after a short-bout of HFD is in line with some 5,17,18 but not all studies [1][2][3][4] examining the effect of short-term HFD on metabolism in mice. Possibly, differences in dietary composition, housing conditions, genetic background or age at dietary intervention may have contributed to observed differences in body weight gain.…”

Section: Discussionsupporting

confidence: 83%

A short bout of HFD promotes long-lasting hepatic lipid accumulation

et al. 2015

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A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for 8 weeks did not fully normalize glucose tolerance. In addition, mice exposed to a short bout of HFD revealed significantly increased liver fat accumulation paralleled by elevated portal free fatty acid levels after 8 weeks of recovery feeding compared to exclusively chow-fed littermates. In conclusion, a short bout of HFD has long-lasting effects on hepatic lipid accumulation and glucose tolerance.

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Section: Discussionsupporting

confidence: 83%

A short bout of HFD promotes long-lasting hepatic lipid accumulation

et al. 2015

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“…Therefore, the decrease in blood glucose levels after post-exercise glucose administration is mainly influenced by glucose uptake in skeletal muscle. While previous studies showed that consuming an HFD for 3 d did not influence glucose uptake in skeletal muscle at rest (24,25), our results suggest that HFD intake for 3 d before exercise attenuates glucose uptake in skeletal muscle during the post-exercise phase.…”

Section: Discussioncontrasting

confidence: 95%

“…While some studies reported that rodents fed an HFD for 3 d do not have impaired glucose uptake in skeletal muscle at rest (24,25), we found that HFD intake for 3 d had significant negative effects on skeletal muscle glycogen and blood glucose levels after post-exercise glucose administration. As it has been shown that consumption of an HFD for only 1 d attenuates carbohydrate oxidation (45,46), a reduction of carbohydrate metabolism in skeletal muscle could occur after 1 or several days of HFD intake.…”

Section: Discussioncontrasting

confidence: 78%

“…Previous studies showed that HFD feeding for a longer period (2 or 4 wk) impairs insulinstimulated glucose uptake in skeletal muscle, which is a major rate-limiting step for glycogen synthesis, after endurance exercise in rats (18,19). In addition, HFD intake for 2-5 d attenuates blood glucose disposal during a glucose tolerance test (20, 21) and insulin sensitivity during a hyperinsulinemic-euglycemic glucose clamp (22, 23) in both humans and rodents, while some studies reported that HFD intake for 3 d does not affect glucose uptake in skeletal muscle at rest (24,25). Furthermore, although enhanced insulin sensitivity in skeletal muscle and the whole body by physical exercise is generally thought to persist for 24-48 h, a single bout of exercise following a 3 d HFD does not improve wholebody insulin sensitivity (26).…”

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confidence: 99%

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Pre-Exercise High-Fat Diet for 3 Days Affects Post-Exercise Skeletal Muscle Glycogen Repletion

Takahashi

Matsunaga

Tamura

et al. 2017

J Nutr Sci Vitaminol

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Summary Previous studies have shown that the short-term intake of a high-fat diet (HFD) impairs glucose metabolism. In this study, we investigated the influences of pre-exercise HFD intake for 3 d on post-exercise glycogen repletion in skeletal muscle in ICR mice. Mice received either an HFD (57% kcal from fat, 23% kcal from carbohydrate; HFD group) or standard laboratory chow (13% kcal from fat, 60% kcal from carbohydrate; Con group) for 3 d before exercise. Mice performed treadmill running at 25 m/min for 60 min and were orally administered a glucose (2 mg/g body weight) solution immediately after and at 60 min after exercise. A negative main effect of pre-exercise HFD intake was observed for skeletal muscle glycogen concentration from the pre-exercise phase to 120 min of post-exercise recovery (p,0.01). Blood glucose concentration in the HFD group was significantly higher than in the Con group at 120 min after exercise (p,0.01). No significant difference was observed in plasma insulin concentration. There were no significant between-group differences in the phosphorylation state of Akt Thr308, AMPK Thr172, AS160 Thr642, or glycogen synthase Ser641 or in glucose transporter 4 protein levels during post-exercise recovery. Our results suggest that the intake of a pre-exercise HFD for 3 d affects post-exercise glycogen repletion in skeletal muscle without impairing the insulin signaling cascade. Key Words skeletal muscle, post-exercise recovery, high-fat diet, glucoseThe pre-exercise glycogen store in skeletal muscle is considered a major determinant of exercise performance during moderate-to high-intensity exercise (1-4). When exercise intensity exceeds around 60-65% VO2max, the skeletal muscle glycogen store is the predominant source of energy (5, 6). Moreover, recent studies suggest that glycogen per se is important for skeletal muscle force production by the modulating excitationcontraction coupling process (7). When individuals are involved in multiple training sessions and competitions over successive days or within a day, enhancing glycogen repletion in skeletal muscle after exercise is essential for improving performance during subsequent exercise.Some athletes alter their dietary composition of carbohydrate and fat for several days to enhance their exercise performance. For example, adaptation to a ketogenic diet, which severely restricts carbohydrate intake (,20 g/d or 5% of total daily energy intake) and contains high fat levels and an adequate amount of protein, has been shown to be useful for weight control without detrimental effects on skeletal muscle mass, power output, or strength after not only long-term (.2 wk) but also short-term (7 d) administration (8-10). Adaptation to a ketogenic diet increases fat utilization and reduces carbohydrate reliance during exercise without impairing endurance capacity at 62-64% VO 2max under a state of insufficient carbohydrate availability (overnight fasting) (11). However, as a ketogenic diet sometimes causes side effects, including increased perceived exertio...

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“…Effects of pomegranate and green tea extracts on protein synthesis and degradation signaling pathways after a HFD HFD and chemically induced ER stress are known to independently impair the Akt/mTOR signaling pathway in muscle [46,47]. Therefore, we wanted to test if the pomegranate and green tea extracts associated with HFD were able to abolish this inhibition.…”

Section: Discussionmentioning

confidence: 99%

Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice

et al. 2014

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Purpose We tested the hypothesis that polyphenol-rich extracts can reduce endoplasmic reticulum (ER) stress induced by a high-fat diet (HFD) in skeletal muscle of mice. Methods Mice were randomly assigned to four groups receiving during 20 weeks either a standard chow control (CTRL), or a HFD supplemented, or not, with pomegranate (HFD ? P) or green tea (HFD ? GT) extracts. After the nutritional intervention, mice were killed and gastrocnemius muscles were taken. Proteins and mRNA were measured by Western blot and RT-qPCR, respectively. Results Body weight gain and visceral fat were higher in HFD, HFD ? P and HFD ? GT than in CTRL. The markers of the unfolded protein response BiP, XBP1u, XBP1s and ATF4 were higher only in HFD. In HFD ? P and HFD ? GT, this increase was not observed except for CHOP, which was elevated in all HFD groups. HFD increased also markers of ubiquitin-proteasome pathway, autophagy and oxidative stress, which were kept low in HFD ? P and HFD ? GT groups. Conclusion Our data provide evidence for a protective effect of pomegranate and green tea extracts against ER stress, oxidative stress and protein degradation induced by HFD in skeletal muscle. They give arguments for a usefulness of these natural nutritional compounds to fight against cellular dysfunctions related to fat excess.

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Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Cited by 345 publications

References 48 publications

A short bout of HFD promotes long-lasting hepatic lipid accumulation

A short bout of HFD promotes long-lasting hepatic lipid accumulation

Pre-Exercise High-Fat Diet for 3 Days Affects Post-Exercise Skeletal Muscle Glycogen Repletion

Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice

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