Distinct patterns of gene expression changes in the colon and striatum of young mice overexpressing alpha-synuclein support Parkinson Disease as a multi-system process
Abstract:Background: Evidence supports a role for the gut-brain axis in Parkinson Disease (PD). Mice overexpressing human wild type α–synuclein (Thy1-haSyn) exhibit slow colonic transit prior to motor deficits, mirroring prodromal constipation in PD. Identifying molecular changes in the gut could provide both biomarkers for early diagnosis and gut-targeted therapies to prevent progression.
Objective: To identify early molecular changes in the gut-brain axis in Thy1-haSyn mice through gene expression profiling.
Method… Show more
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