Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal β-Glucans and Toll-Like Receptor Agonists

Huang, Haibin; Ostroff, Gary R.; Lee, Chrono K.; Wang, Jennifer; Specht, Charles A.; Levitz, Stuart M.

doi:10.1128/iai.00086-09

Cited by 136 publications

(127 citation statements)

References 53 publications

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“…Previous reports by Hoffman et al 91 and by Abel and Czop 92 described similar cytokine profiles in rat alveolar macrophages and human monocytes. In accordance, a recent study by Huang et al 93 described likewise a strong TNF-α production by IFN-γ primed human DCs upon yeast glucan particle stimulation. This striking increase of cytokine production is caused by IFN-γ priming, which is believed to lower the response threshold of innate cells to microparticulate β-glucans.…”

Section: Microparticulate β-Glucans Stimulate Innate Immunitysupporting

confidence: 73%

“…93,94,[98][99][100][101][102][103] Based on the in situ layer-by-layer synthesis through electrostatic interactions, the group of Soto initially engineered yeast cell wall particles for DNA delivery. 104 This encapsulation strategy enables a high nucleic acid capacity and delivery, in addition to the oral bioavailability of β-glucan particles and their inherent β-glucan receptor targeting capacity toward APCs.…”

Section: β-Glucan Particles As Orally Delivery Of Nucleic Acids (Sirnmentioning

confidence: 99%

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Recent advances in oral vaccine development

Smet

Allais

Cuvelier

2014

Human Vaccines & Immunotherapeutics

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Section: Microparticulate β-Glucans Stimulate Innate Immunitysupporting

confidence: 73%

Section: β-Glucan Particles As Orally Delivery Of Nucleic Acids (Sirnmentioning

confidence: 99%

Recent advances in oral vaccine development

Smet

Allais

Cuvelier

2014

Human Vaccines & Immunotherapeutics

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“…GPs can be efficiently loaded with antigen (N90%), target M cells for uptake and also exhibit an intrinsic immunomodulatory capacity [210,211]. β-glucans are fungal PAMPs, signalling through receptors such as dectin-1 and complement receptor 3 expressed on DCs, monocytes and neutrophils [209,212].…”

Section: Synthetic Particle-based Strategiesmentioning

confidence: 99%

Delivery strategies to enhance oral vaccination against enteric infections

Davitt

Lavelle

2015

Advanced Drug Delivery Reviews

132

102

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“…by DNA (in zymosan) and by LPS (in curdlan). The importance of treating zymosan with hot alkali or organic solvents to remove TLR2 or TLR4 ligands is well recognized [29] although TLR9 activation by zymosan was not previously reported. Less attention has been given thus far to potential endotoxin contamination of curdlan, a product of the Gram-negative bacterium Alcaligenes faecalis.…”

mentioning

confidence: 99%

Recognition of yeast nucleic acids triggers a host‐protective type I interferon response

et al. 2011

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Although type I interferons (IFN-a/b) have been traditionally associated with antiviral responses, their importance in host defense against bacterial pathogens is being increasingly appreciated. Little is known, however, about the occurrence and functional role of IFN-a/b production in response to pathogenic yeasts. Here, we found that conventional DCs, but not macrophages nor plasmacytoid DCs, mounted IFN-b responses after in vitro stimulation with Candida spp. or Saccharomyces cerevisiae. These responses absolutely required MyD88, a Toll-like receptor (TLR) adaptor molecule, and were partially dependent on TLR9 and TLR7. Moreover, Candida DNA, as well as RNA, could recapitulate the IFN-b response. After intravenous challenge with Candida albicans, most mice lacking the IFN-a/b receptor died from their inability to control fungal growth, whereas all WT controls survived. These data suggest that recognition of yeast nucleic acids by TLR7 and TLR9 triggers a host-protective IFN-a/b response.Key words: Candida albicans . Cytokines . DCs . Fungal infections . Macrophages Supporting Information available online IntroductionCandida albicans (C. albicans) is, among fungi, the most common pathogen of humans. Although they are normally harmless commensals of the intestinal and urinary tract, C. albicans and other Candida species can cause recurrent mucosal infections in otherwise healthy subjects and life-threatening conditions in hospitalized or immunocompromised patients [1]. In recent years, C. albicans has become the fourth most common cause of bloodstream infections, with an incidence of between 1 and 24 cases per 100 000 and a mortality rate of 30-50% [2]. Since the host immune status is the major factor that determines the transition of C. albicans from commensalism to pathogenicity, elucidating the mechanisms underlying immune response initiation, particularly those underlying recognition of fungal components, is crucial to developing new and more effective strategies to combat these infections. In fact, despite the availability of new classes of antifungal drugs, current available therapies are only partially effective and are associated with significant side effects.Antimicrobial responses are initiated by the activation of germ-line-encoded receptors (pattern-recognition receptors, PRRs) expressed by cells of the innate immune system, mainly by macrophages and DCs, which monitor potential portals of pathogen entry. Each PRR binds directly or indirectly to one or more evolutionary conserved microbial molecules (pathogenassociated molecular patterns, PAMPs) and triggers intracellular signal transduction cascades culminating in distinctive transcriptional and nontranscriptional responses. By this mechanism, PRRs link microbial recognition with the selective activation of specific arms of the innate immune system [3].Ã These authors have contributed equally to this study. Eur. J. Immunol. 2011. 41: 1969-1979 DOI 10.1002 Immunity to infection 1969Considerable progress has been recently made in the identification ...

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Distinct Patterns of Dendritic Cell Cytokine Release Stimulated by Fungal β-Glucans and Toll-Like Receptor Agonists

Cited by 136 publications

References 53 publications

Recent advances in oral vaccine development

Recent advances in oral vaccine development

Delivery strategies to enhance oral vaccination against enteric infections

Recognition of yeast nucleic acids triggers a host‐protective type I interferon response

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