Distinct neural generators of sensory gating in schizophrenia

Williams, Terrance J.; Nuechterlein, Keith H.; Subotnik, Kenneth L.; Yee, Cindy M.

doi:10.1111/j.1469-8986.2010.01119.x

Cited by 59 publications

(48 citation statements)

References 78 publications

(92 reference statements)

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“…The frontocortical sources during the processing of auditory stimuli have been implicated in the MEG studies of nonpatients (Mayer et al, 2009;Weisser et al, 2001) and intracranial recordings in epileptic patients (Grunwald et al, 2003;Korzyukov et al, 2007). Moreover, Williams et al (2011) reported EEG evidence of an association between enhanced gating-related dipole activity in the dorsolateral prefrontal cortex and higher gating ratios in schizophrenia subjects, which might point to a relationship between working memory and sensory gating.…”

Section: Discussionmentioning

confidence: 95%

Evoked and induced oscillatory activity contributes to abnormal auditory sensory gating in schizophrenia

et al. 2011

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The ratio of magnetoencephalogram-recorded brain responses occurring 50ms after paired clicks (S2-evoked M50/S1-evoked M50) serves as a measure of sensory gating. An abnormally large ratio is commonly found in schizophrenia. Whether this abnormality indicates impaired gating is debated. Using event-related oscillations the present study sought to elucidate processes contributing to the phenomenon of altered M50 gating ratio. Schizophrenia inpatients (n=50) showed the expected large M50 gating ratio relative to 48 healthy controls, which correlated with less induced frontally generated activity in the 10-15Hz frequency band starting 200ms before the onset of S2. Patients also produced smaller alpha (8-12Hz) and gamma (60-80Hz) responses to S1. Results suggest that the deviant gating ratio in schizophrenia is a consequence of a complex alteration in the processing of incoming information that cannot be attributed to impaired gating alone.

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Section: Discussionmentioning

confidence: 95%

Evoked and induced oscillatory activity contributes to abnormal auditory sensory gating in schizophrenia

et al. 2011

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“…Source localization studies implicate a neural network involving prefrontal cortex, particularly the dorsolateral prefrontal cortex (dlPFC), superior temporal gyrus (STG), hippocampus, and thalamus in the generation of P50 and its suppression (25, 26). Notably, dlPFC and hippocampus have been associated with working memory dysfunction in schizophrenia (27, 28), while prefrontal cortex, hippocampus, and STG structural and functional abnormalities have been implicated in efficient information processing (29, 30).…”

Section: Discussionmentioning

confidence: 99%

Clinical and Cognitive Significance of Auditory Sensory Processing Deficits in Schizophrenia

Hamilton

Williams

Ventura

et al. 2018

AJP

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Objective Although patients with schizophrenia exhibit impaired suppression of the P50 event-related brain potential (ERP) to the second of two identical auditory stimuli during a paired-stimulus paradigm, uncertainty remains over whether this deficit in inhibitory gating of auditory sensory processes has relevance for patients’ clinical symptoms or cognitive performance. We examined associations between P50 suppression deficits and several core features of schizophrenia to address this gap. Method P50 was recorded from 52 patients with schizophrenia and 41 healthy individuals during a standard auditory paired-stimulus task. The Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS) were used to assess clinical symptoms, and the MATRICS Cognitive Consensus Battery (MCCB) measured cognitive performance in a subsample of 39 patients. Correlation and regression analyses were used to examine P50 suppression in relation to clinical symptom and cognitive performance measures. Results Patients with schizophrenia demonstrated a deficit in P50 suppression when compared to healthy participants, replicating prior research. Within the patient sample, impaired P50 suppression covaried reliably with greater difficulties in attention, poorer working memory, and reduced processing speed. Conclusions Impaired suppression of auditory stimuli is associated with core pathological features of schizophrenia, increasing confidence that P50 inhibitory processing can inform the development of interventions that target cognitive impairments in this chronic and debilitating mental illness.

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“…The observed over-activity, which has now been replicated using a more ecologically valid stimulus (Tregellas et al, 2009), was interpreted as consistent with the concept of impaired inhibitory function in schizophrenia (Lewis and Moghaddam, 2006). A recent high-density EEG study by Williams and colleagues (2011) also suggested involvement of these regions in P50 sensory gating, and abnormal function of the hippocampus and prefrontal cortex in patients (Williams et al, 2011). …”

Section: Introductionmentioning

confidence: 99%

The effect of distracting noise on the neuronal mechanisms of attention in schizophrenia

Tregellas

Smucny

Eichman

et al. 2012

Schizophrenia Research

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Objective-The inability to ignore irrelevant environmental noise is a common problem for people with schizophrenia. The purpose of this study was to determine if the neuronal response to distracting noise is related to mechanisms of altered attention observed in the illness.Method-Twenty-two outpatients with schizophrenia and seventeen healthy comparison subjects performed a selective attention task in the presence or absence of distracting environmental noise while undergoing functional magnetic resonance imaging at 3T. A separate condition examining passive response to the distracting noise also was included.Results-Group differences in neuronal response during the attention task were magnified by distracting noise, with the greatest difference being less response by patients, relative to comparison subjects, in the temporoparietal junction. Separate passive listening to distracting noise resulted in greater hippocampal response in patients, relative to comparison subjects. Across all subjects, hippocampal response to noise was inversely related to the degree to which the attention-task-related network was up-regulated to perform the task during distracting noise.Conclusions-Given the observed hippocampal hyperactivity in response to environmental noise in patients and the inverse relationship between hippocampal response to noise and the effects of noise on the task-related network, hippocampal hyperactivity may contribute to impaired recruitment of attention networks in schizophrenia.

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Distinct neural generators of sensory gating in schizophrenia

Cited by 59 publications

References 78 publications

Evoked and induced oscillatory activity contributes to abnormal auditory sensory gating in schizophrenia

Evoked and induced oscillatory activity contributes to abnormal auditory sensory gating in schizophrenia

Clinical and Cognitive Significance of Auditory Sensory Processing Deficits in Schizophrenia

The effect of distracting noise on the neuronal mechanisms of attention in schizophrenia

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